Cell Injury Flashcards
What are the 2 main characteristic changes in irreversible cell injury?
- inability to reverse mitochondrial dysfunction
- major disturbance in membrane function
What type of cell death is associated with ATP depletion?
Necrosis
What are the 2 main morphologic changes with reversible cell injury?
- cellular swelling
- fatty change
Which type of cellular injury results in:
- cellular swelling
- fatty changes
Reversible injury
What are mallory bodies?
Damaged intermediate filaments in hepatocytes
What is anthracosis?
Accumulation of carbon in the lungs.
Due to coal or smoke inhalation.
What is steatosis?
It is a fatty change, an abnormal accumulation of TAGs within parenchymal cells
Alpha-1-anti-trypsin deficiency is seen in which organ?
Liver
Abnormal metabolism can cause a normal cell to become fatty in which organ?
Liver.
–> normal substance produced, metabolism inadequate to remove it causing a fatty liver
Lacking or inheriting a defected enemy can result in which disease?
Storage disease
ie lysosomal storage disease
Describe the 3 steps of nucleus degradation for irreversible cellular injuries:
1) karyolysis
2) karyorrhexis
3) pyknosis
Hypoxic cell death in CNS causes which type of necrosis?
Liquefactive/colliqative necrosis
In which type of necrosis do we see blood vessels involved?
Fibrinoid necrosis (vascular necrosis)
