Cell Divison, Diveristy, Differentiation Flashcards
What’s in interphase
G1
S
G2
G0
Cell has left cell cycle:
To differentiate
Apoptosis
Senescence
Senescence
Cells no longer divide
Check points in cell cycle
At G1
At G2
Why are there
checkpoints
To prevent uncontrolled division that would lead to tumours To detect and repair damage to DNA
M phase
Checkpoint chemical triggers condensation of chromatin Cell growth stops 4 stages of mitosis Cytokinesis then occurs
G1
Cells grow Transcription of genes to make RNA occurs Synthesis of biological molecules occur e.g. protein synthesis
S phase
DNA replicates (doubles) Each chromosome has two sister chromatids Once the cell has entered this phase, it is committed to completing the cell cycle
Why does S phase
happen very rapidly
Exposed DNA base pairs are more susceptible to mutagens so this phase happens quickly to reduce the chances of mutations
G2
Cells grow Chemicals stimulate histones and formation of the spindle Organelles duplicate
Prophase
Chromosomes
condense- chromatids shorten, thicken and DNA supercoils
Centrioles duplicate and move to opposite
poles
Cytoskeleton protein (tubulin)threads form a spindle between centrioles.
Nuclear envelope
breaks down
Nucleolus no
longer visible
Metaphase
Chromosomes align at equator and attach by their centromeres Two sister chromatids of each chromosome are attached to spindle fibres
Anaphase
Centromere splits Sister chromatids of a pair are pulled towards opposite poles and directions of the cell by motor proteins walking along tubulin threads to spindle fibres shortening (now chromosomes)
Telophase
Chromosomes decondense Spindle disappears Nuclear envelope reforms and a nucleolus reappears cells contain two nuclei each genetically identical to one an other
Cytokinesis in an
animal cell
plasma membrane folds inwards the middle of the cell pinches inwards, creating an indentation called the cleavage furrow
Cytokinesis in a
plant cell
The cell plate forms down the middle of the cell, creating a new wall that partitions it in two
Where does mitosis
occur in plants
Roots
Shoots
Haploid
Having only one set of
chromosomes
Homologous
Matching chromosomes, containing the same genes at the same places (loci) May contain different alleles for some of the genes
Diploid
Having two complete
sets of chromosomes
(found as pairs)
Maternal homologues
These chromosomes will have the same genes as the maternal homologue in the chromosome pair
Paternal homologues
These chromosomes will have the same genes as the paternal homologue in the chromosome pair
Metaphase I
Homologue pairs line up at the metaphase plate The orientation of pairs is random
Anaphase I
Homologues separate to the opposite ends of the cell Sister chromatids stay together