Cell division, cell diversity and cellular organisation Flashcards
What is the cell cycle?
a highly ordered sequence of events that takes place in a cell, resulting in division of the cell, and the formation of two genetically identical daughter cells
What are the two main phases of the cell cycle?
- interphase
- mitosis
What is interphase divided into?
G1, S and G2
What is mitosis divided into?
Prophase, metaphase, anaphase, telophase
What happens during interphase?
- DNA is replicated and checked for errors
- protein synthesis
- mitochondria and chloroplasts grow and divide, increasing in number
- normal metabolic processes occur eg respiration
What happens at G1?
- cell growth
- cellular components
- protein synthesis
What happens in the S phase if interphase?
Each of the chromosomes are duplicated
What happens at G2?
- cell size increases
- the cell checks the duplicated chromosomes for errors, making any repairs that are needed
- energy store increases
What happens at cytokinesis?
Cytoplasm divides
What happens at G0?
When the cells leave the cycle either temporarily or permanently
Why do cells enter G0?
- differentiation
- cells may be damaged
- apoptosis
Give an example of a cell that can be stimulated to go back into the cell cycle after G0?
Lymphocytes
Why is it important that the cell cycle is controlled?
To ensure the fidelity of cell division
What are the roles of checkpoints in the cell cycle?
They monitor and verify whether the process at each phase has been accurately completed before the cell is allowed to progress to the next phase
What does the G1 checkpoint check for?
- cell size
- nutrients
- growth factors
-DNA damage
What does the G2 checkpoint check for?
- cell size
- DNA replication
What does the spindle assembly checkpoint check for?
Chromosomes attachment to spindle
Why do cells divide by mitosis?
- growth
- repair
- asexual reproduction
What does asexual reproduction?
- fungi
- plants
- some animal cells
What is a centromere?
A structure on a chromosome that allows two chromatids to attach to each other or to the spindle during cell division
What is a chromatid?
One of two halves of a replicated chromosome
What is a homologous chromosome?
A pair of chromosomes of the same length and carrying the same genes in the same positions- one is maternal and one is paternal
What happens before prophase?
DNA combines with histone proteins to form a dense complex chromatin
What happens during prophase?
- chromatin fibres coil and condense to form visible chromosomes
-nucleolus disappears - nuclear envelope starts to break down
- microtubules form the spindle that links the poles of the cell
- spindle attaches to centromere to move chromosomes to centre of cell
- nuclear envelope disappears
What happens during metaphase?
- spindle fibres pull the chromosomes by their centromeres to align them around the equator of the cell
- this is called the metaphase plate
- centromeres replicate
What happens during anaphase?
- centromeres holding the sister chromatids together divide
- the chromatids separate
- chromatid acids are dragged to opposite ends
What happens during telophase?
- chromatids reach the poles and bunch together
- now called chromosomes
- nuclear envelope forms around each group
What happens after mitosis (cytokinesis)?
- divides cell into two separate cells at end of telophase
- animal cells form a cleavage furrow, where the cytoskeleton pulls the plasma membrane inwards until it fuses
- plant cells cannot form a cleavage furrow due to the cell walls
- at the metaphase plate the Golgi vesicles fuse with each other and the plasma membrane to create a cell division
- new sections of cell wall must then form
What is meiosis?
Type of cell division used to produce gametes
What is meiosis used for?
To halve chromosome number in preparation for sexual reproduction
What does meiosis result in?
Haploid cells containing N chromosomes (e.g 23 for humans)
Diploid cells containing 2N chromosomes (e.g 46 for human)
What happens in meiosis 1?
- divide the homologous pairs of chromosomes
- creates two haploid cells
What happens in meiosis 2?
- divides the sister chromatids
- creates 4 haploid cells form
What happens in early prophase 1 in meiosis?
- chromosomes replicated
- starting to become more visible
- centrioles replicate
- nucleus disappears
What happens in mid prophase 1 in meiosis?
- chromosomes are fully condensed
- homologous chromosomes pair up
What happens in late prophase 1 in meiosis?
- crossing over begins (of chromosomes)
- prepare to break and reconnect to another chromatid
- occurs at chiasmata
- nuclear envelope disintegrates
- spindles form
What happens in metaphase 1 in meiosis?
- chromosomes line up at equator randomly
- centromere attaches to spindles
- allows for independent assortment
- chromosomes separate randomly
What happens in anaphase 1 in meiosis?
- while chromosomes move to opposite poles
-crossing over is compete- chiasmata separates
What happens in telophase 1 in meiosis?
- nuclear envelope reforms
- ends up with 2 nuclei - chromosomes uncoil to form chromatin
What happens in cytokinesis in meiosis 1?
Separates cytoplasm to give two haploid daughter cells
What happens in prophase two in meiosis?
- chromosomes condense
- nuclear envelope starts to break down
- centrioles replicate
- spindle starts developing
What happens in metaphase two in meiosis?
- chromosomes line up at equator
- spindle fibres attaches to centromere
- independent (random) assortment of chromatids
What happens in anaphase two in meiosis?
- centromeres divide- each chromatid is called a chromosome
- chromosomes pulled to opposite poles
- randomly segregated
What happens in telophase two in meiosis?
- chromosomes uncoil
- nuclear envelope reforms
- each nucleus has a chromatid from original homologous pairs
What happens in cytokinesis after meiosis two?
Two more daughter cells from each division= 4 haploid cells in total (not genetically identical)
Does mitosis have single or double division of chromosomes?
Single
Does meiosis have single or double division of chromosomes?
Double
Does mitosis have single or double division of nucleus?
Single
Does meiosis have single or double division of nucleus?
Double
What happens to the number of chromosomes in mitosis?
Stays the same (haploid)
What happens to the number of chromosomes in meiosis?
Halves (diploid)
Do homologous chromosomes come together in mitosis?
No
Do homologous chromosomes come together in meiosis?
Yes
Are chiasmata formed in mitosis?
No
Are chiasmata formed in meiosis?
Yes