Cell Division Flashcards
What happens in G1 phase of interphase?
Growth phase:
- Protein synthesis
- Cell increases in size
- Organelles replicate
What happens in S phase in interphase?
Synthesis phase:
- DNA is replicated in the nucleus
What happens in G2 phase of interphase?
Second growth phase:
- Cell continues to increase in size
- Duplicated DNA is checked for errors
What happens in G0 phase?
The cell leaves the cycle either temporarily or permanently
What happens in the mitotic phase?
- Mitosis (nucleus divides)
- Cytokinesis (cytoplasm divides)
Why might a cell leave the cycle?
- Differentiation: A cell that becomes specialised is no longer able to divide
- The DNA of a cell may be damaged
- As you age, the number of these cells in your body increases: linked to age related diseases such as cancer and arthritis
A few types of cells that enter G0 can be stimulated to go back into the cycle, e.g. lymphocytes in an immune response
What happens at the G1 checkpoint?
End of G1 phase:
- Cell size
- Nutrients
- Growth factors
- DNA damage
What happens at the G2 checkpoint?
End of G2 phase:
- Cell size
- DNA replication
- DNA damage
What happens at the spindle assembly checkpoint?
Point in mitosis:
- Chromosomes attached to spindle
What is mitosis necessary for?
- Growth
- Replacement
- Repair of tissues in multicellular organisms
- Asexual reproduction
What happens in prophase?
- Chromatin fibres coil & condense = chromosomes
- Nucleolus disappears
- Nuclear envelope disappears
- Spindle formation begins
What happens in metaphase?
Chromosomes line up on the equator
What happens in anaphase?
- Centromeres divide
- Chromatids are separated and pulled to opposite poles
What happens in telophase?
- Chromatids have reached poles = chromosomes
- The 2 new sets of chromosomes assemble at each pole
- Nuclear envelope reforms
- Chromosomes uncoil
- Nucleolus is formed
- Cytokinesis begins
Describe cytokinesis in animals
- A cleavage furrow forms around the middle of the cell
- The cell-surface membrane is pulled inwards by the cytoskeleton until close enough to fuse around middle, forming 2 cells
Describe cytokinesis in plants
- Vesicles from Golgi assemble on equator
- Vesicles fuse with each other and membrane, dividing cell into 2
- New cell wall forms along the new sections of membrane
What are alleles?
Different versions of the same gene
What happens in P1 in meiosis?
- Chromosomes condense
- Nucleolus disappears
- Nuclear envelope disappears
- Spindle formation begins
- Homologous chromosomes pair up, forming bivalents
What can occur in P1 that causes genetic variation?
- Crossing over, when bivalents get chromatids entangled and genetic material is transferred between them
What is chiasmata?
The points at which crossing over occurs (chromatids break and rejoin?)
What happens in M1 in meiosis?
- Homologous pairs of chromosomes line up on the equator
What happens in A1 of meiosis?
- Homologous chromosomes are pulled to opposite poles and chromatids stay joined together
- Any potential chiasmata on recombinant chromatids are also pulled apart
What can occur in M1 that causes genetic variation?
- Independent assortment, when the orientation of each homologous pair is random. It can result in many different combinations of alleles facing the poles
What happens in T1 of meiosis?
- Chromosomes assemble at each pole
- Nuclear membrane reforms
- Chromosomes uncoil
- Undergoes cytokinesis