cell communication/transduction Flashcards
direct contact
cells must be touching
animals: gap junctions
plants: plasmodesmata
immune cells (antigens)
local regulators
messages travel a short distance
paracrine & synaptic signaling
long distance signaling
hormones
endocrine signaling
circulatory (insulin)
3 stages of cell signaling
1) reception
2) transduction
3) response
stage 1: reception
ligand binds to receptor and activates it
initiates transduction signal
plasma membrane receptors
most common
bonds to large, polar ligands
can’t go through membrane
intracellular receptors
found in cytoplasm or nucleus or target cell
travels through plasma membrane
stage 2: transduction
conversion of extracellular signal to an intracellular signal that will bring about a response
phosphorylation vs dephosphorylation in cells
phosph: relays signal
dephosp: shuts off pathways
second messengers
signal is amplified
help relay message and amplify response
stage 3: response
converts signal to a response
alters cell processes
2 main membrane receptors in animals
GPCRs: GDP -> GTP, G protein is inactive until bonded to GPCR
ion channels: gate opens or closes when ligand binds to receptor