Cell Bio final-Immune Flashcards
Humoral immunity and Cell-Mediated immunity are types of?
Acquired immunity
Innate immunity lacks the memory of an infection and these cells respond first to inflammation
Neutrophils
Plasma cells display memory in this type of immunity?
Humoral immunity
Macrophages, dendritic cells, and follicular dendritic cells are known as?
Accessory cells
Passive Immunity is inherited
T/F?
true, maternal immunity
Post disease gives rise to memory cells in case the antigen were to attack again. this describes?
Active Immunity
which are Primary Lymphoid organs?
thymus and bone marrow
Which are secondary lymphoid organs?
lymph nodes, tonsils, and spleen
what do Primary follicles lack?
germinal centers
Germinal centers and B cell Corona are characteristic of?
Secondary lymphoid follicles
This antibody is found in saliva, breast milk, GI tract, and respiratory tracts
Ig-A
In response to allergic reactions and in Parasitic worm infections like Paragonimus westermani (chinese lung fluke), this antibody is elevated
Ig-E
Whats the major immunoglobin found circulating in the blood and responsible for antibody reactivity?
Ig-G
Ig-M is the first antibody expressed on which cells?
B cells
B cells also express another antibody besides Ig-M. which one and it usually is associated with what maternal-fetal condition?
Ig-D. Rh incompatibility
Which part of an antibody binds to the antigen?
Fc region of Light chain
Which part of the antibody recognizes the antigen?
Fab region of the heavy chain
MHC class II proteins are involved in?
B cell maturation
CD8+ T cells are cytolytic in nature and recognize this on the surface of Macrophages
MHC I proteins
Which kind of T cells mature into helper T’s to recognize MHC II molecules?
CD4+
MHC I molecules are found on the surface of all cells as a way of identifying their belonging to the body. it is NOT found on?
RBC’s and trophoblasts.
What are the antigenic property antigens expressed from broken down foreign particles?
Epitopes
Clonal expansion describes when T cells activate B cells to proliferate in response to antigen detection. T/F?
true
according to the complement system, this pathway is activated by the antibody binding to the pathogen.
Classic
What is the most important Opsonin?
C3b
Opsonization is poking holes in the pathogen membrane by?
MAC- membrane attack complex…mac daddy!
of the activation sequence, what initiates the complement cascade?
C1-s
C1-q binds to which region of the Ig antibody?
Fc region
4b2b combine to form?
C3 convertase
Chemotaxis is a term to describe?
the release of chemokines to attract phagocytes to an area of infection/inflammation
lymphocytes that pack a lymphoid organ refers to a?
Parenchyma
Stroma consists of reticular fibers, undifferentiated cells, free and afixed macrophages? T/F?
hell yeah it’s true!!
Are the Cortex and Center of a lymph follicle supplied by the same vascularization or different?
different!
What is the entry and exit point for efferent and afferent lymhatics?
Lymph hilus
The capsule of lymph follicles are composed of these fibers?
dense collagen fibers, elastic fibers, smooth muscle fibers
Outer cortex of the lymph node contains?
follicles
High endothelial venules are the entry point to the outer cortex. T/F?
FALSE!! it is for the INNER CORTEX
Site of reentry into lymph stream
Medulla cortex
Hassall’s corpuscles produce cytokines necessary for T cell maturation and are composed of single positive T cells. They are located in the?
Thymus Medulla
Which cells enter the cortex from blood and proliferate in the subcapsular area?
Double negative T cells
Double positive T cells move to this section of the thymus
outer cortex
TCR receptors and either CD4 or CD8 receptors are expressed on these cells that eventually move to the inner cortex
Single positive T cells
Splenic B cells with germinal centers are located?
White pulp of spleen
Periarteriolar lymphoid sheath (PALs) are characteristic of?
splenic white pulp
The site of erythrophagocytosis
Cords of Billroth in splenic red pulp
These cells serve as antigen presenting phagocytic dendritic cells in the skin
Langerhan cells
Melanin is derived from this amino acid
tyrosine
sweat glands include merocrine and apocrine glands. T/F?
true.
