Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Cell Bio And Histology > CAMs and Junctional Complexes > Flashcards

CAMs and Junctional Complexes Flashcards

0
Q

How does type IV collagen differ from type I?

A

Does not form fibrils

Produced by the epithelial tissue, unlike type I which is secreted by fibroblasts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

Major component of the basal lamina, three chains (alpha, beta, gamma), has binding sites for (integrins, type IV collagen, entactin, and heparin sulfate-proteogylcans)

A

LaminIN

Not to be confused with laminA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Fibronectin is made up of what?

A

Two polypeptide chains cross linked by disulfide bonds

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the two forms of fibronectin and what can you tell me about them?

A

Cellular fibronectin- produced by fibroblasts and apart of the extra cellular matrix

Plasma- secreted into the bloodstream and produced by hepatocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

The four binding sites for fibronectin are?

A

Fibrin, heparin, collagen, integrin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

CAMs can be divided into two groups….

A

Calcium dependent and calcium INdependent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Calcium dependent CAMs can be further divided into two more groups…

A

Please welcome the Cadherins and the Selectins!!!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Calcium independent CAMs also have two subgroups

A

You might have heard of the famous integrins and the immunoglobulin superfamily!!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Cadherins can be even further subdivided into two more categories. Wtf are they?

A

The very classy and the non classy. For real. Talk about socioeconomic norms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Those classy Cadherins typically form what kind of dimers?

A

Cis- and trans- homophilic. Ha! Homo. Lol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

The classy Cadherins have three distinct types. They are?

A

E- epithelial (associated with tumor cell metastasis)

N-nervous system

P-placenta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

The non classy Cadherins can be found loitering around where and they include these two hooligans…

A

Found in the desmosomes (macula adheren) and includes the desmocollins and desmogleins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

E Cadherin has four extra cellular domains for which ions and they form what kind of dimers?

A

Calcium ions. Cis- homophilic dimers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

The HVA sequences facilitates what kind of E Cadherin dimers?

A

Trans homophilic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Small proteins that link the cytoplasmic end of Cadherin to cytoplasmic actin

A

Catenins!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Catenin has three forms. Give them to me now!

A

Beta and gamma plakoglobin

Alpha catenin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

They serve as the major interface between the Cadherins that hold the adjacent cells together and he actin cytoskeleton a of those cells

A

Catenins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Binds directly to cytoplasmic actin

A

Alpha catenin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

T/F beta catenin serves as a transcription cofactor

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Selectins bind to what making them apart of the lectins group.

A

Carbohydrates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

This binding site for carbohydrates is located at the extra cellular end of the selectin?

A

carbohydrate recognition domain (CRD)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What’s required in order for selectin to bind to the CRD?

A

Calcium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What are the three classes of Selectins

A

P-platelets

E-activated endothelial cells

L-leukocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Integrins bind to two things…

A

EC matrix and cytoskeleton

24
Q

The two EC domain molecules that integrin binds to…

A

Laminin and fibronectin

25
Q

Integrin binds to this sequence in fibronectin and laminin

A

RGD (Arginine-Arg, Glycine-Gly, and Aspartic acid-Asp)

26
Q

What are the three connecting proteins integrin is associated with?

A

Talin, vinculin, and alpha actinin.

27
Q

What’s the role of integrin in hemidesmosomes?

A

To link the basal domain of cells, via intermediate filaments such as keratin, to the EC matrix.

28
Q

Who are the elite members of the Ig superfamily?

A

N-cam and I-cam 1 & 2

29
Q

These are neural adhesion molecules that mediate homo loving and hetero loving interactions.

A

N-Cam. Probably for the best.

30
Q

Tell me what the I-CAMs do!

A

Facilitates the transendothelial migration of leukocytes (our white blood cell friends)

31
Q

The three wise junctional complexes are?

A

Adherens (anchoring)

Occludens (tight)

Gap junctions (communicating)

32
Q

What do adherens do and where can they be found?

A

They anchor cells together and reinforce the physical integrity of the cell and the tissues they make up. Found on the basolateral surfaces of epithelial cells. (In between the cells)

33
Q

Establishes an impermeable barrier between adjacent cells that prevents para cellular transport and maintains concentration differences.

A

Occludens-tight junctions

34
Q

Gap junctions can be found in where?

A

Cardiac and neuronal cells

35
Q

What’s the purpose of a gap junction anyways? Do they need braces?

A

To rapidly exchange ions and small molecules to coordinate cell activities. And they like their gap

36
Q

I’m of the Adheren or Occludens variety.

A

Zonula

37
Q

Referred to as “belt like” complexes, they are also associated with intracellular actin.

A

Zonula (Adheren or Occludens)

38
Q

Maculas are of the adherens variety only but they go by two other names.

A

Desmosomes and hemidesmosomes

39
Q

Maculas are very spotty and they like to associate themselves with these “filas”

A

Intracellular Intermediate filaments (tonofilaments) such as keratin

40
Q

Pemhigus foliaceus is an autoimmune blistering disease above the stratum spinosum layer in the epidermis. Loss of this Cadherin protein is the cause…

A

Desmoglein 1

41
Q

Adherens are anchoring junctions characterized by intracellular spaces filled with what?

A

Desmoglein and desmocollins

42
Q

What are the Anchoring junctions that anchor the basal domain of the epithelial cell to the basal lamina

A

Hemidesmosomes

43
Q

The hemidesmosome plaque is anchored to the basal lamina on the outer membrane by two things…they are?

A

Laminin 5 (anchoring filaments) and integrin alpha6beta4

44
Q

A pair of transmembrane proteins that are responsible for the occlusive properties of the tight junction

A

Claudins and Occludins

45
Q

Claudins and Occludins attach intracellularly to which type of zonula Occluden proteins?

A

ZO-2 & ZO-3

46
Q

Zonula Occludens have a couple more transmembrane proteins of the fruity kind. What are they and how are they stabilized?

A

JAMs (junctional adhesion molecules) and Nectin are immunoglobulin loops stabilized by Disulfide bonds

47
Q

Afadin-Nectin complex is anchored to ZO-1 forming what? The interaction of them forms this.

A

Cis-homo dimers interact with each other to form trans-homo dimers through the extracellular region.

48
Q

JAMs are associated intracellularly with?

A

Afadin and ZO-1

49
Q

How are focal adhesions different than hemidesmosomes?

A

The intracellular attachment is NOT to tonofilaments such as keratin but to ACTIN filaments via connecting proteins.

50
Q

T/F Focal adhesions are integrins.

A

True

51
Q

Gap junctions as composed of?…

A

Connexons

52
Q

Connexons are made up of?

A

6 connexins forming a hexagonal structure with a hollow center.

53
Q

What are Clusters of intracellular channels that allow direct passage of small signaling molecules between adjacent cells to coordinate cell responses.

A

Gap junctions

54
Q

Do gap junctions open or close in high concentration of calcium ions?

A

They Close

55
Q

This disease Mutation in connexin 32 results in progressive degeneration of peripheral nerves characterized by distal muscle weakness, atrophy, and impairment of deep tendon reflexes.

A

Charcot Marie tooth demyelination neuropathy

56
Q

Mutation in connexin 50 is associated with?…

A

Congenital cataracts, leading to blindness.

57
Q

Highly expressed in the cochlea, mutations in Cx26 results in?…

A

Deafness

Cell Bio And Histology (17 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions