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New Pathology TN > Cell as a Unit of Health and Disease > Flashcards

Cell as a Unit of Health and Disease Flashcards

1
Q

Smooth endoplasmic reticulum(TOPNOTCH)Robbins Basic Pathology, 9th ed. p.6

A

Abundant in liver and gonads; used for steroid hormone and lipoprotein synthesis

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2
Q

Rough endoplasmic reticulum(TOPNOTCH)Robbins Basic Pathology, 9th ed. p.6

A

Synthesizes new proteins for the plasma membrane

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3
Q

Smooth endoplasmic reticulum(TOPNOTCH)Robbins Basic Pathology, 9th ed. p.6

A

Modifies hydrophobic compounds into water-soluble molecules

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4
Q

Lysosomes(TOPNOTCH)Robbins Basic Pathology, 9th ed. p.6

A

Organelles with degradative enzymes that permit digestion of macromolecules

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5
Q

Peroxisomes(TOPNOTCH)Robbins Basic Pathology, 9th ed. p.6

A

Organelles that break down fatty acids, generating hydrogen peroxide in the process

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6
Q

Cytoskeleton(TOPNOTCH)Robbins Basic Pathology, 9th ed. p.10

A

Intracellular scaffolding that allows cells to adopt a particular shape and organization. Also maintains polarity.

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7
Q

Endosomal vesicles(TOPNOTCH)Robbins Basic Pathology, 9th ed. p.6

A

Shuttles internalized material to the appropriate site. Also directs newly synthesized materials to the cell surface or targeted organelle.

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8
Q

Mitochondria(TOPNOTCH)Robbins Basic Pathology, 9th ed. p.6

A

Production site of ATP and metabolic intermediates needed for anabolic metabolism

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9
Q

Mitochondria(TOPNOTCH)Robbins Basic Pathology, 9th ed. p.6

A

Contain important sensors of cell damage that can initiate and regulate the process of programmed cell death.

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10
Q

Passive membrane diffusion(TOPNOTCH)Robbins Basic Pathology, 9th ed. p.9

A

Water and carbon dioxide diffuse across the cell lipid bilayers through this TYPE OF DIFFUSION

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11
Q

Exocytosis(TOPNOTCH)Robbins Basic Pathology, 9th ed. p.9

A

The process by which large molecules are exported from cells.

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12
Q

Transcytosis(TOPNOTCH)Robbins Basic Pathology, 9th ed. p.9

A

The movement of endocytosed vesicles between the apical and basolateral compartments of the cell, which is how large proteins are transferred across an epithelial barrier.

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13
Q

Caveolae(TOPNOTCH)Robbins Basic Pathology, 9th ed. p.9

A

Non-coated plasma membrane invagination (“little caves”) associated with cAMP, GPI-linked molecules, SRC-family kinases, and folate receptor.

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14
Q

Pinocytosis(TOPNOTCH)Robbins Basic Pathology, 9th ed. p.9

A

A fluid-phase process during which the plasma membrane invaginates and is pinched off to form a cytoplasmic vesicle.

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15
Q

Receptor-mediated endocytosis(TOPNOTCH)Robbins Basic Pathology, 9th ed. p.20

A

Major uptake mechanism for macromolecules such as transferrin and LDL, which bind to receptors localized in clathrin-coated pits.

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16
Q

Actin(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 11

A

Most abundant cytosolic protein in cells.

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17
Q

Microtubules(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 11

A

They serve as connecting cables for “molecular motor” proteins that use ATP to move vesicles, organelles, or other molecules.

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18
Q

Occluding junctions (tight junctions)(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 11

A

Cell junction that seal adjacent cells together, creating a barrier that restricts paracellular movement of ions and other molecules.

19
Q

Anchoring junctions (desmosomes) (tight junctions)(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 11

A

Cell junctions that mechanically attach cells and their intracellular cytoskeletons to other cells or to extracellular matrix.

20
Q

Communicating junctions (gap junctions) (TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 12

A

Junctions that mediate the passage of chemical or electrical signals from one cell to another.

21
Q

Golgi apparatus(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 12

A

Cell organelle that consists of stacked cisternae that progressively modify protein

22
Q

Paracrine signaling(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 16

A

Cell-cell signaling pathway: cells in immediate vicinity are affected.

23
Q

Autocrine signaling(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 16

A

Cell-cell signaling pathway: molecules secreted by a cell affect tat same cell.

24
Q

Synaptic signaling(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 16

A

Cell-cell signaling pathway: activated neurons secrete neurotransmitters at specialized cell junctions onto target cells.

25
Q

Endocrine signaling(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 16

A

Cell-cell signaling pathway: A mediator is released into the bloodstream and acts on target cells at a distance.

26
Q

Intracellular receptors(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 16

A

Vitamin D and steroid hormones are cell-permeable ligands for this type of receptor.

27
Q

Growth factors(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 18

A

Its major role is to stimulate the activity of genes required for cell growth and cell division.

28
Q

Epidermal growth factor(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 19

A

Growth factor that stimulates keratinocyte migration and formation of granulation tissue

29
Q

Transforming growth factor-alpha(TGF-a)(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 19

A

Growth factor that stimulates proliferation of hepatocytes and other epithelial cells.

30
Q

Hepatocyte growth factor(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 19

A

Growth factor: enhances proliferation of hepatocytes and increases cell motility

31
Q

Vascular endothelial growth factor (VEGF)(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 19

A

Growth factor: stimulates proliferation of endothelial cells and increases vascular permeability

32
Q

Platelet-derived growth factor (PDGF) (VEGF)(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 19

A

Growth factor that is chemotactic for neutrophils, fibroblasts, and smooth muscles, and activates proliferation of fibroblasts and endothelial cells.

33
Q

Fibroblast growth factors (FGFs) (VEGF)(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 19

A

Growth factor that is chemotactic and mitogenic for fibroblasts and stimulates angiogenesis and ECM protein synthesis

34
Q

Elastin(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 23

A

Component of ECM responsible for the ability of tissues to recoil and recover their shape after physical deformation.

35
Q

Proteoglycan(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 23

A

Component of ECM that confer resistance to compressive forces, also provide lubrication between bony surfaces.

36
Q

Laminin(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 24

A

The most abundant glycoprotein in basement membrane.

37
Q

Fibronectin(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 24

A

A major component of the interstitial ECM.

38
Q

Integrins(TOPNOTCH)Robbins Basic Pathology 9th ed. p. 24

A

A large family of transmembrane glycoproteins that allow cells to attach to ECM constituents, linking the intracellular cytoskeleton with the outside world.

39
Q

G1/Presynthetic growth-S/DNA synthesis-G2/Premitotic growth- M/mitotic phase (TOPNOTCH) Robbins Basic Pathology, 9th ed., p.25

A

Sequence of events in cell cycle

40
Q

Self-renewal and assymetric division. (TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 26

A

Two important properties of stem cells

41
Q

Embryonic stem cells(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 27

A

Undifferentiated stem cells which are totipotent and can be induced to form specialized cells of all three germ cell layers.

42
Q

Tissue stem cells(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 27

A

Variety of stem cell with limited repertoire of differentiated cells that they can generate.

43
Q

Proteasomes(TOPNOTCH)Robbins Basic Pathology, 9th ed. p.6

A

Specialized tye of “grinder” that selectively chews up denatured proteins, releasing peptides

New Pathology TN (24 decks)

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