Ceftriaxone CPG

Question 1

Ceftriaxone - Presentation

Answer 1

1 g sterile powder in a glass vile

Question 2

Ceftriaxone - Pharmacology

Answer 2

Cephalosporin antibiotic

Question 3

Ceftriaxone - Metabolism

Answer 3

Excreted unchanged in urine (33% - 67%) and in bile

Question 4

Ceftriaxone - Primary Emergency Indications

Answer 4

1. Suspected meningococcal septicaemia
2. Severe sepsis (consult only)

Question 5

Ceftriaxone - Contraindications

Answer 5

1. Allergy to Cephalosporin antibiotics

Question 6

Ceftriaxone - Precautions

Answer 6

1. Allergy to Penicillin antibiotics

Question 7

Ceftriaxone - Route of Administration

Answer 7

IV (preferred)

IM (if IV access unavailable)

Question 8

Ceftriaxone - Side effects

Answer 8

Nausea

Vomiting

Skin rash

Question 9

Ceftriaxone - Special notes

Answer 9

Usual dose: adult 1 g, child 50 mg/kg (max. 1 g)

Ceftriaxone IV must be made up to 10 mL using sterile water and dose administered over 2 minutes

Ceftriaxone IM must be made up to 4 mL using 1% Lignocaine and dose administered in lateral upper thigh

IM/IV effects:

Onset: n/a

Peak: n/a

Duration: n/a