Aspirin CPG

Question 1

Aspirin- Presentation

Answer 1

300 mg chewable tablet

300 mg soluble/water dispensable tablet

Question 2

Aspirin - Pharmacology

Answer 2

An analgesic, antipyretic, anti-inflammatory and antiplatelet aggregation agent

Actions:

• To minimise platelet aggregation and thrombus formation in order to retard the progression of coronary artery thrombosis in ACS
• Inhibits synthesis of prostaglandins - anti-inflammatory actions

Question 3

Aspirin - Metabolism

Answer 3

Converted to salicylate in the gut mucosa and liver; excreted mainly by the kidneys

Question 4

Aspirin - Primary emergency indications

Answer 4

1. ACS

Question 5

Aspirin - Contraindications

Answer 5

1. Hypersensitivity to aspirin/salicylates
2. Actively bleeding peptic ulcers
3. Bleeding disorders
4. Suspected dissecting aortic aneurysm
5. Chest pain associated with psychostimulant OD if systolic BP >160mmHg

Question 6

Aspirin - Precautions

Answer 6

1. Peptic ulcers
2. Asthma
3. Pt on anticoagulants

Question 7

Aspirin - Route of administration

Answer 7

Oral

Question 8

Aspirin - Side effects

Answer 8

Heartburn, nausea, gastrointestinal bleeding

Increased bleeding time

Hypersensitivity reactions

Question 9

Aspirin - Special notes

Answer 9

Aspirin is C/I for use in acute febrile illness in children and adolescents

The anti-platelet effects of Aspirin persist for the natural life of platelets

Onset: n/a

Peak: n/a

Duration: 8-10days