CDK inhibitors

Question 1

What is a type of CDK inhibitor? Name it

Answer 1

IBRANCE, it inhibits G1

Question 1

What do CDK inhibitors do?

Answer 1

they prevent the activation of the CDK cyclin

Question 2

What do G2/M checkpoint inhibitors do to the checkpoint activity?

Answer 2

they decrease the checkpoint activity

Question 3

Why do G2/M checkpoint inhibitors decrease the checkpoint activity?

Answer 3

They decrease the checkpoint activity because the checkpoint inhibition inhibit the G2/M checkpoint

Question 4

what do cancer cells that are in deficient in p53 rely on?

Answer 4

they rely on the G2/M checkpoints to halt the cell cycle and prevent cell death

Question 5

What occurs when P53 is present and you use checkpoint inhibitors?

Answer 5

if you have P53, you don’t want to inhibit it since you are doing the opposite of what you want, you won’t excite P53 since there is no more CDK and with no P53, there is less of a chance of cell dying and it would help cancer

P53 is a way to kill the cells and you don’t want to halt it

Question 6

What happens if you use checkpoint inhibitors with the loss of P53?

Answer 6

If you have a loss, you will drive the cell through the cell cycle and then you can kill it through a P53 independent mechanisms

which causes mitotic catastrophe and this drives it forward

Question 7

What is mitotic slippage?

Answer 7

mitotic slippage is when you do not allow for the formation of microtubule and they can lead to death, but in mitotic slippage you have a polyploid and enough to survive, which is the opposite of what you want

mitotic slippage you accumulate more genomic instability and cancer likes this

Question 8

what does CDK-cyclin do?

Answer 8

controls the cell-cycle progression via phosphorylation of the target genes, such as tumor suppressor protein retinoblastoma