Angiogenesis

Question 1

What are angiogenesis?

Answer 1

the formation of new blood vessels

Question 2

What do angiogesis do to help what kind of cancer cells?

Answer 2

Tumors are limited in growth to around 1-2mm due to the limited diffusion of oxygen/nutrients and removal of waste, so cells are basically choking with no oxygen

thus cancer cells look for angiogenicm a way to induce blood vessels

Question 3

what is the angiogenic switch and what happens?

Answer 3

cancer initiate an aniogenic switch

they increase release of pro-angiogenic molecules (VEGF) and decrease the release of anti-angiogenic molecules (thrombospondin)

Question 4

What does angiogenesis result to?

Answer 4

resulting in new blood vessel growth

growth of cancer

invasion into the bloodstream

metastasis

Question 5

What is metastasis?

Answer 5

the development of secondary malignant growths at a distance from a primary site of cancer

they are taken over

Question 6

what is the percentage of patients with invasive cancer that also have metastases at diagnosis?

Answer 6

70%

Question 7

Fill in the blank:

Metastasis leads to ___ of cancer-realted deaths

Answer 7

95%

Question 8

What is metastatic cascade?

Answer 8

the process whereby aggressive cancer cells leave the primary tumor, travel through the bloodstream, and eventually reach distant organs to develop one or several metastases