CD (Clusters of Differentiations)

Question 1

What is CD (Clusters of differentiation)?

Answer 1

Cell surface antigens of all cells that can be recognised by antibodies

Question 2

Investigation to detect type of CD

Answer 2

Immunophenotyping by ‘flow cytometry’

Question 3

What is CD1 ?

Answer 3

HLA molecule that presents lipid molecules

Question 4

CD1 functions

Answer 4

To present lipid antigens (or molecules) to T cells

Question 5

CD2 is found on-?

Answer 5

Thymocytes, T cells, some NK (Natural Killer cells)

Question 6

CD2 >> Functions

Answer 6

• Acts as a ligand for CD58 and CD59
• Signal transduction
• Cell adhesion

Question 7

What is CD3 ?

Answer 7

• The signalling component of T cell receptor (TCR) complex
• Common between T-helper and cytotosic-T cells

Question 8

CD4 >> Functions

Answer 8

• Co-receptor for HLA class II
• A receptor used by HIV to enter T cells
• Present on T-helper cells

Question 9

CD5 is found on- ?

Answer 9

the majority of the mantle cell lymphomas

Question 10

CD8 >> Functions

Answer 10

• Co-receptor for HLA class I (= MHC class I)
• Also found on a subset of myeloid dendritic cells
• Present on cytotoxic T cells

Question 11

CD14 is found on-?

Answer 11

On macrophages

(Cell surface markers for macrophages)

Question 12

CD15 is expressed on-?

Answer 12

RS (Reed-Sternberg) cell (along with CD30)

Question 13

CD28 >> Functions

Answer 13

Interacts with B7 on antigen presenting cell (APC) as costimulation signal

Question 14

CD30 is expressed on-?

Answer 14

RS (Reed-Sternberg) cell (along with CD15)

Question 15

CD95 >> Functions

Answer 15

• Acts as FAS receptor
• Involved in apoptosis

Question 16

Which CD is a co-receptor of HLA class II?

Answer 16

CD4

Question 17

Which CD is a co-receptor for HLA class I?

Answer 17

CD8

Question 18

Which CD is used by HIV to enter T cells?

Answer 18

CD4

Question 19

Which CD is present on T-helper cells?

Answer 19

CD4

Question 20

Which CD is present on cytotoxic T cells?

Answer 20

CD8

Question 21

Which CD is common between T-helper cells and cytotxic T cells?

Answer 21

CD3

Question 22

Which CD is found on a subset of myeloid dendritic cells?

Answer 22

CD8

Question 23

Which CD acts as the signalling component of the T cells receptor (TCR complex?

Answer 23

CD3

Question 24

Which CD is involved in signal transduction and cell adhesion on thymocytes, T cells, and some NK cells?

Answer 24

CD2

Question 25

CD that acts as a ligand between CD58 and CD59

Answer 25

CD2

Question 26

Which CD is related to class I MHC (HLA) molecule?

Answer 26

CD1

Question 27

Which CDs are found on RS (Reed-Sternberg) cell?

Answer 27

CD15

CD30

Question 28

Which CD does Interact with B7 on antigen presenting cell (APC) as costimulation signal?

Answer 28

CD28

Question 29

Which CD is the cell surface marker of macrophages?

Answer 29

CD14

Question 30

Which CD does act as the FAS receptor and involve in apoptosis?

Answer 30

CD95

Question 31

The most common T regulatory cells population

Answer 31

CD4 + CD25 + Fox-P3 + T regulatory cells

Question 32

T regulatory cells population (CD4+ CD25+ Fox-P3 + T regulatory cells) >> Functions

Answer 32

• The most important T regulatory cell population
• important role in regulating immune responses (T cell response)
• prevent the development of autoimmunity
• Do NOT produce IL-2
• Among the regulatory T cells >>>
  
  • Small population is CD8+ regulatory T cells
  • Larger population is CD4+ regulatory cells
• Among the CD4+ T cells, only 5-10% are regulatory T cells
• All T cells express the CD3 receptor (including regulatory T cells)