CC: Epithelium, CT, Skin Flashcards
Celiac Disease autoimmune disease is caused by failure of the permeability layer of _______
Zonula occludens (caused by some microbes and toxins)
Where is an entry point for virus binding Hep C, Coxsackie B, Rotavirus, West Nile, Dengue?
Zonula Occludens virus binding as an entry point
Where can a virus disruption in the nectin-actin protein complex entry occur? Example: Measles virus
Zonula adherens
Mutation in ___ is associated with non-syndromic congenital deafness.
Mutations in Connexin-26 (Cx26)
Which proteins have been associated with inherited cataracts?
Connexins-46 and Connexin-50
What specialized junction can cause Skin blistering: Bulbous Pemphigoid
Hemidesmosome: Collagen XVII fails in attachment to antibodies
Affects especially BP230
Conversion of one type epithelium to another type which occurs under some conditions of stress to the epithelium such as excess abrasion or chronic infections:
- Columnar to squamous
- Squamous to columnar can occur as in Barrett esophagus
Metaplasia in Epithelial Cells
What is a subtype of Epithelial Cancer?
Adenocarcinomas (adenomas) are a subtype of the carcinomas which occur in glandular tissue of organs like the colon, prostate, and breast
Intermediate filament composition changes from cytokeratin-containing intermediate filaments to vimentin-containing intermediate filaments during:
The Epithelial-Mesenchymal Transition (EMT)
breakdown of desmosomal and hemidesmosomal junctions motile and metastatic of breast nd prostate cancer cells
Single endocrine cells interspersed in epithelium of different origin (neural crest) than epithelium.
Diffuse Neuroendocrine System (DNES)
Which Gland is Ductless?
Endocrine Glands
Endocrine, Paracrine, Autocrine
Ducts are simple or compound
Exocrine Glands
Tulular, Alveolar (acinar)
A defective synthesis of collagen due to lack of vitamin C and iron as cofactors for hydroxilation of ____ and _____ in collagen synthesis.
Example: Scurvy
proline and lysine
What type of collagen is affected?
Osteogenesis imperfecta: easily fractured brittle bones, abnormal teeth, weak tendons, blue sclera, hearing loss
Defects in type I collagen
Bones
What protein family defect is causing Ehlers-Danlos Syndromes?
Collagen molecule synthesis
What collagen type affects Classical Ehlers-Danlos Syndrome?
Defects in collagen type V
It illustrates that the involvement of type V collagen in formation of type I collagen fibrils may be important!!