CBC 2

Question 1

MON

Answer 1

3-9%
Largest of WBC
Monocytosis↑chronic infection with necrotic content (phagocytic macrophages) presentation of lymphocytes to antigen, also ↑in TB & viral infections
Monocytopaenia ↓ aplstic anemia, Acute myeloid leukemia, glucocorticoids, myelotoxic drugs,

Question 2

PLT

Answer 2

150-400 *109/l
↓-Thrombocytopenia  DIC syndrome, chemotherapy in malignant tumor, bleeding

Question 3

ESR

Answer 3

2-15 mm/h
ESR 2-15mm/h Viscosity of the fluid
1. Inflammation - ↑  hypermobility of vascular part, ↓in albumin so low viscosity which ↑ESR
2. Antibodies – globulins – high level of globulin – can ↓ viscosity (normally 60% protein and 40%globulin, change in ratio can ↑ESR)
3. Complex antigen antibody- absorption to RBC – three complexes they lead to ↑ESR
4. Malignant tumour - ↓albumin & formation of antigen-antibody complex  ↑ESR
5. Pregnancy -↑ESR

Question 4

Reticulocytes

Answer 4

1-6%
↑ anemia bcs are immature cell and need to compensate body for low hemoglobin
↓ reticulocyte count, or reticulocytopenia, typically indicates a decrease in red blood cell production. This may occur in response to a variety of conditions such as bone marrow failure, certain infections or medications that suppress the bone marrow, or nutritional deficiencies such as iron, vitamin B12, or folate deficiencies.

Question 5

Megakaryocytes

Answer 5

0
Immature platelets
Infections and inflammatory conditions: Certain infections or inflammatory conditions such as chronic hepatitis C, HIV/AIDS, and systemic lupus erythematosus (SLE) may also lead to increased production of megakaryocytes.

Medications: Some medications like heparin, interferon-alpha, and some chemotherapeutic agents may cause an increase in the number of megakaryocytes.