categories of MS - RS

Question 1

remitting relapsing (RR)

Answer 1

episodes of rapid, abrupt, and unpredictable deterioration w/ variable degrees of recovery over time and minimal residual disability

Question 2

RR –> periods b/w relapse

Answer 2

characterized by lack of dz progression

Question 3

RR is the

Answer 3

most common

85-90%

Question 4

after 10-15 yrs –> RR

Answer 4

will develop into progressive MS in 30-40% of individuals

Question 5

assistive devices –> RR

Answer 5

50% need 15 yrs post onset

Question 6

attacks rendering –> RR

Answer 6

40% w/ attacks rendering them non ambulatory never regain ability to ambulate

Question 7

RR characterized by

Answer 7

clearly defined acute attacks with full recovery or w/ sequelae and residual deficit upon recovery

Question 8

primary progressive aka

Answer 8

relapsing progressive

Question 9

PP characterized by

Answer 9

steady progression of continuous worsening w/ minor fluctuations

but w/o distinct periods of relapses and remissions

Question 10

what is there rather than remissions

Answer 10

plateaus

Question 11

who does PP affect

Answer 11

people who are older at dz onset

Question 12

PP is

Answer 12

approx 10%

Question 13

PP characterized (2)

Answer 13

dx showing progression of disability from onset, w/o plateaus or remissions or with occasional plateaus and temp minor improvements

Question 14

secondary progressive (SP) begins as

Answer 14

RR

Question 15

SP is followed by

Answer 15

progression with or without occasional relapse, minor remission or plateau

Question 16

SP decline may include

Answer 16

new neurological sxs

worsening cognitive fxn

other deficits

Question 17

SP begins with

Answer 17

an initial RR course

followed by progression of variable rate that may also include occasional relapses and minor remissions

Question 18

progressive relapsing (PR)

Answer 18

steady progressive deterioration from onset with clear, acute, relapses that may or may not resolve

Question 19

periods b/w relapses (PR)

Answer 19

characterized by continued progression

Question 20

PR pace of deterioration

Answer 20

can vary

Question 21

PR is the

Answer 21

least common of all MS subtypes

Question 22

PR shows

Answer 22

progression from onset but with clear acute relapses or w/o full recovery

Question 23

myelocortical MS (MCMS)

Answer 23

new subtype founded in 2018

Question 24

pathophys MCMS

Answer 24

neuronal loss with no demyelination of the white matter

Question 25

MCMS pathophys –> neurons become

Answer 25

swollen and look like typical MS lesions

indicative of white matter myelin loss on MRI

Question 26

MCMS pathophys –> implications

Answer 26

neurodegeneration and demyelination can occur independently in MS