categories of MS - RS Flashcards
remitting relapsing (RR)
episodes of rapid, abrupt, and unpredictable deterioration w/ variable degrees of recovery over time and minimal residual disability
RR –> periods b/w relapse
characterized by lack of dz progression
RR is the
most common
85-90%
after 10-15 yrs –> RR
will develop into progressive MS in 30-40% of individuals
assistive devices –> RR
50% need 15 yrs post onset
attacks rendering –> RR
40% w/ attacks rendering them non ambulatory never regain ability to ambulate
RR characterized by
clearly defined acute attacks with full recovery or w/ sequelae and residual deficit upon recovery
primary progressive aka
relapsing progressive
PP characterized by
steady progression of continuous worsening w/ minor fluctuations
but w/o distinct periods of relapses and remissions
what is there rather than remissions
plateaus
who does PP affect
people who are older at dz onset
PP is
approx 10%
PP characterized (2)
dx showing progression of disability from onset, w/o plateaus or remissions or with occasional plateaus and temp minor improvements
secondary progressive (SP) begins as
RR
SP is followed by
progression with or without occasional relapse, minor remission or plateau
SP decline may include
new neurological sxs
worsening cognitive fxn
other deficits
SP begins with
an initial RR course
followed by progression of variable rate that may also include occasional relapses and minor remissions
progressive relapsing (PR)
steady progressive deterioration from onset with clear, acute, relapses that may or may not resolve
periods b/w relapses (PR)
characterized by continued progression
PR pace of deterioration
can vary
PR is the
least common of all MS subtypes
PR shows
progression from onset but with clear acute relapses or w/o full recovery
myelocortical MS (MCMS)
new subtype founded in 2018
pathophys MCMS
neuronal loss with no demyelination of the white matter
