Catabolism of amino acids N's (& proteins N's) & C's Flashcards

1
Q

What is the type of the reaction indicated by A?

  1. reductive amination
  2. oxidative deamination
  3. transamination
  4. transdeamination
  5. dehydrogenation
A

answer:

  1. transamination.
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2
Q

What is the type of the reaction indicated by B?

  1. reductive amination
  2. oxidative deamination
  3. transamination
  4. transdeamination
  5. reductive deamination
A

answer:

  1. Oxidative deamination
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3
Q

Identify compound A in the following pathway!

  1. glutamate
  2. glutamine
  3. α-ketoglutarate
  4. aspartate
  5. alanine
A

answer:

  1. α-ketoglutarate
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4
Q

Identify compound B in the following pathway!

  1. glutamate
  2. glutamine
  3. α-ketoglutarate
  4. aspartate
  5. alanine
A

answer:

  1. glutamate
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5
Q

Identify cofactor B in the following reaction!

  1. NAD(P)H + H+
  2. FAD
  3. NAD(P)+
  4. ADP
  5. ATP
A

answer:

  1. NAD(P)H + H+
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6
Q

Identify substrates A and B in the following reaction!

  1. A: glutamine, B: glutamate
  2. A: glutamate, B: α-ketoglutarate
  3. A: α-ketoglutarate, B: glutamate
  4. A: glutamate, B: glutamine
  5. A: α-ketoglutarate, B: glutamine
A

answer:

  1. A: glutamate, B: α-ketoglutarate
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7
Q

Which enzyme catalyzes the reaction shown below?

  1. glutaminase
  2. asparaginase
  3. α-ketoglutarate dehydrogenase
  4. glutamine synthase
  5. glutamate dehydrogenase
A

answer:

  1. glutamine synthase
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8
Q

Identify substrate A and product B in the following reaction!

  1. A: glutamate, B: glutamine
  2. A: α-ketoglutarate, B: glutamate
  3. A: aspartate, B: asparagine
  4. A: oxaloacetate, B: aspartate
  5. A: α-ketoglutarate, B: glutamine
A

answer:

  1. A: glutamate, B: glutamine
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9
Q

Identify compound A in the following reaction!

  1. alanine
  2. aspartate
  3. pyruvate
  4. asparagine
  5. NH4+
A

answer:

  1. NH4+
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10
Q

Identify cofactor A in the following reaction!

  1. ATP
  2. NADH + H+
  3. NADPH + H+
  4. NAD+
  5. tetrahydrobiopterin
A

answer:

  1. ATP

*** the correct answer is actually Mg-ATP ***

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11
Q

Which enzyme catalyzes the reaction shown below?

  1. glutaminase
  2. asparaginase
  3. glutamate dehydrogenase
  4. aspartate aminotransferase
  5. α-ketoglutarate dehydrogenase
A

answer:

  1. Glutaminase
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12
Q

Identify substrate A and product B in the following reaction!

  1. A: glutamine, B: glutamate
  2. A: glutamine, B: α-ketoglutarate
  3. A: glutamate, B: α-ketoglutarate
  4. A: asparagine, B: aspartate
  5. A: aspartate, B: oxaloacetate
A

answer:

  1. A: glutamine, B: glutamate
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13
Q

Identify compounds A and B in the following reaction!

  1. A: H2O, B: NH4+
  2. A: ATP, B: ADP
  3. A: pyruvate, B: alanine
  4. A: α-ketoglutarate, B: glutamate
  5. A: CO2, B: carbamoyl phosphate
A

answer:

  1. A: H2O, B: NH4+
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14
Q

Identify enzyme A in the pathway shown below!

  1. carbamoyl phosphate synthase I
  2. ornithine carbamoyl transferase
  3. N-acetylglutamate synthase
  4. argininosuccinate synthase
  5. arginase
  6. argininosuccinate lyase
A

answer:

  1. carbamoyl phosphate synthase I
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15
Q

Identify enzyme B in the pathway shown below!

  1. carbamoyl phosphate synthase I
  2. ornithine carbamoyl transferase
  3. N-acetylglutamate synthase
  4. argininosuccinate synthase
  5. arginase
  6. argininosuccinate lyase
A

answer:

  1. ornithine carbamoyl transferase
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16
Q

Identify enzyme C in the pathway shown below!

  1. carbamoyl phosphate synthase I
  2. ornithine carbamoyl transferase
  3. N-acetylglutamate synthase
  4. argininosuccinate synthase
  5. arginase
  6. argininosuccinate lyase
A

answer:

  1. argininosuccinate synthase
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17
Q

Identify enzyme D in the pathway shown below!

  1. carbamoyl phosphate synthase I
  2. ornithine carbamoyl transferase
  3. N-acetylglutamate synthase
  4. argininosuccinate synthase
  5. arginase
  6. argininosuccinate lyase
A

answer:

  1. argininosuccinate lyase
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18
Q

Identify enzyme E in the pathway shown below!

  1. carbamoyl phosphate synthase I
  2. ornithine carbamoyl transferase
  3. N-acetylglutamate synthase
  4. argininosuccinate synthase
  5. arginase
  6. argininosuccinate lyase
A

answer:

  1. Arginase
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19
Q

Identify compound A in the pathway shown below!

  1. carbamoyl phosphate
  2. ornithine
  3. citrulline
  4. 3-phosphoglycerate
  5. phosphoenolpyruvate
A

answer:

  1. carbamoyl phosphate
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20
Q

Identify compound B in the pathway shown below!

  1. carbamoyl phosphate
  2. ornithine
  3. citrulline
  4. argininosuccinate
  5. arginine
  6. N-acetylglutamate
A

answer:

  1. Ornithine
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21
Q

Identify compound C in the pathway shown below!

  1. carbamoyl phosphate
  2. ornithine
  3. citrulline
  4. argininosuccinate
  5. arginine
  6. N-acetylglutamate
A

answer:

  1. Citrulline

*L-citrulline

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22
Q

Identify compound D in the pathway shown below!

  1. carbamoyl phosphate
  2. ornithine
  3. citrulline
  4. argininosuccinate
  5. arginine
  6. N-acetylglutamate
A

answer:

  1. argininosuccinate
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23
Q

Identify compound E in the pathway shown below!

  1. carbamoyl phosphate
  2. ornithine
  3. citrulline
  4. argininosuccinate
  5. arginine
  6. N-acetylglutamate
A

answer:

  1. arginine

*L-arginine

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24
Q

Identify compound A in the pathway shown below!

  1. aspartate
  2. fumarate
  3. succinate
  4. glutamate
  5. arginine
A

answer:

  1. Aspartate
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25
Identify compound A in the pathway shown below! 1. aspartate 2. fumarate 3. succinate 4. citrulline 5. oxaloacetate
answer: 2. Fumarate
26
What is the allosteric activator of enzyme A? 1. N-acetylglutamate 2. carbamoyl phosphate 3. glutamine 4. ATP 5. arginine
answer: 1. N-acetylglutamate
27
Identify compounds A and B in the pathway shown below! 1. A: ATP, B: ADP 2. A: 2 ATP, B: 2 ADP 3. A: ATP, B: AMP 4. A: GTP, B: GDP 5. A: GTP, B: GMP
answer: 3. A: ATP, B: AMP more accurate- A: Mg-ATP, B: Mg-AMP + PPi
28
What are the substrates indicated by A and B? 1. CO2 and NH4+ 2. CO2 and glutamine 3. CO2 and aspartate 4. methyl-THF and NH4+ 5. methylene-THF and glutamine
answer: 1. CO2 and NH4+
29
The figure shows the main pathways of amino acid degradation. What are indicated by A, B and C? 1. A: acetoacetyl-CoA, B: acetyl-CoA, C: pyruvate 2. A: acetyl-CoA, B: acetoacetyl-CoA, C: pyruvate 3. A: propionyl-CoA, B: acetyl-CoA, C: acetoacetyl-CoA 4. A: succinyl-CoA, B: propionyl-CoA, C: methyl-malonyl-CoA 5. A: propionyl-CoA, B: succinyl-CoA, C: α-ketoglutarate 6. A: propionyl-CoA, B: succinyl-CoA, C: methyl-malonyl-CoA
answer: 1. A: acetoacetyl-CoA, B: acetyl-CoA, C: pyruvate
30
The figure shows the main pathways of amino acid degradation. What are indicated by E and F? 1. E: α-ketoglutarate , F: glutamate 2. E: glutamate, F: α-ketoglutarate 3. E: succinyl-CoA, F: propionyl-CoA 4. E: succinyl-CoA, F: methylmalonyl-CoA 5. E: oxaloacetate, F: fumarate 6. E: oxaloacetate, F: pyruvate
answer: 1.E: α-ketoglutarate , F: glutamate
31
The figure shows the main pathways of amino acid degradation. What is indicated by G? 1. α-ketoglutarate 2. succinyl-CoA 3. fumarate 4. oxaloacetate 5. methylmalonyl-CoA 6. citrate
answer: 2. succinyl-CoA
32
The figure shows the main pathways of amino acid degradation. What is indicated by H? 1. α-ketoglutarate 2. succinyl-CoA 3. fumarate 4. oxaloacetate 5. methylmalonyl-CoA 6. acetyl-CoA
answer: 3. Fumarate
33
The figure shows the main pathways of amino acid degradation. What is indicated by I? 1. α-ketoglutarate 2. succinyl-CoA 3. fumarate 4. oxaloacetate 5. acetyl-CoA 6. citrate
answer: 4. oxaloacetate
34
The figure shows the main pathways of amino acid degradation. Which amino acids belong to the group indicated by A? 1. glutamine, arginine, proline 2. tyrosine, phenylalanine 3. asparagine, aspartate 4. methionine, isoleucine, valine 5. tryptophan, tyrosine, lysine 6. alanine, cysteine, serine
answer: 1. glutamine, arginine, proline
35
The figure shows the main pathways of amino acid degradation. Which amino acids belong to the group indicated by B? 1. glutamine, arginine, proline 2. tyrosine, phenylalanine 3. asparagine, aspartate 4. methionine, isoleucine, valine 5. tryptophan, tyrosine, lysine 6. alanine, cysteine, serine
answer: 4. methionine, isoleucine, valine
36
The figure shows the main pathways of amino acid degradation. Which amino acids belong to the group indicated by D? 1. glutamine, arginine, proline 2. tyrosine, phenylalanine 3. asparagine, aspartate 4. methionine, isoleucine, valine 5. tryptophan, tyrosine, lysine
answer: 3. asparagine, aspartate
37
The figure shows the main pathways of amino acid degradation. Which amino acids belong to the group indicated by G? 1. glutamine, arginine, proline 2. tyrosine, phenylalanine 3. asparagine, aspartate 4. methionine, isoleucine, valine 5. tryptophan, tyrosine, lysine 6. alanine, cysteine, serine
answer: 6. alanine, cysteine, serine (Ala, Cys, Gly, Hyp, Ser, Thr)
38
The figure shows the main pathways of amino acid degradation. Which amino acids belong to the group indicated by E? 1. leucine, lysine 2. asparagine, aspartate 3. glutamine, glutamate 4. glycine, serine, alanine 5. valine, methionine, isoleucine
answer: 1. leucine, lysine (Leu, Lys, Phe, Trp, Try)
39
The degradation of the amino acid indicated by A can lead to the formation of succinyl-CoA and acetyl-CoA as well. Which of the following is this amino acid? 1. isoleucine 2. leucine 3. lysine 4. tryptophan 5. tyrosine 6. phenilalanine
answer: 2. Isoleucine (Ile)
40
The degradation of the amino acid indicated by A can lead to the formation of fumarate and acetoacetyl-CoA as well. Which of the following is this amino acid? 1. isoleucine 2. leucine 3. lysine 4. tryptophan 5. threonine 6. phenilalanine
answer: 6. phenilalanine \*also Tyrosine
41
Identify enzymes A, B, C and D in the reactions below! 1. A: asparaginase, B: transaminase, C: glutaminase, D: transaminase 2. A: transaminase, B: asparaginase, C: transaminase, D: glutaminase 3. A: transaminase, B: glutaminase, C: transaminase, D: asparaginase 4. A: glutaminase, B: transaminase, C: asparaginase, D: transaminase 5. A: aspartate dehydrogenase, B: transaminase, C: glutamate dehydrogenase, D: transaminase
answer: 1. A: asparaginase, B: transaminase, C: glutaminase, D: transaminase
42
Identify compounds A, B and C in the reaction below! 1. A: asparagine, B: aspartate, C: oxaloacetate 2. A: glutamine, B: glutamate, C: α-ketoglutarate 3. A: glutamate, B: α-ketoglutarate, C: oxaloacetate 4. A: aspartate, B: oxaloacetate, C: fumarate 5. A: aspartate, B: asparagine, C: α-ketoglutarate
answer: 1. A: asparagine, B: aspartate, C: oxaloacetate
43
Identify enzyme A in the reaction below! 1. asparaginase 2. glutaminase 3. glutamate dehydrogenase 4. α-ketoglutarate dehydrogenase 5. aspartate aminotransferase
answer: 1. asparaginase
44
Identify enzyme B in the reaction below! 1. asparaginase 2. glutaminase 3. glutamate dehydrogenase 4. α-ketoglutarate dehydrogenase 5. transaminase
answer: 5. transaminase
45
Identify compounds A and B in the reaction below! 1. A: H2O, B: NH4+ 2. A: ATP, B: ADP 3. A: pyruvate, B: alanine 4. A: α-ketoglutarate, B: glutamate 5. A: CO2, B: carbamoyl phosphate
answer: 1. A: H2O, B: NH4+
46
Which compound can be indicated by D in the following reaction? 1. alanine 2. pyruvate 3. α-ketoglutarate 4. NH4+ 5. NADH + H+
answer: 1. alanine (c is pyruvate)
47
Identify compounds A, B and C in the reaction below! 1. A: asparagine, B: aspartate, C: oxaloacetate 2. A: glutamine, B: glutamate, C: α-ketoglutarate 3. A: glutamate, B: α-ketoglutarate, C: oxaloacetate 4. A: aspartate, B: oxaloacetate, C: fumarate 5. A: aspartate, B: asparagine, C: α-ketoglutarate
answer: 2. A: glutamine, B: glutamate, C: α-ketoglutarate
48
Identify enzyme B in the reaction below! 1. asparaginase 2. glutaminase 3. glutamate dehydrogenase 4. α-ketoglutarate dehydrogenase 5. transaminase
answer: 5. transaminase
49
Which compund can be indicated by D in the following reaction? 1. alanine 2. pyruvate 3. α-ketoglutarate 4. NH4+ 5. NADH + H+
answer: 1. alanine
50
Which enzyme catalyzes the following reaction? 1. cystine reductase 2. cysteine dioxygenase 3. cystathionine β-synthase 4. cysteine transaminase 5. cystine oxidase
answer: 1. Cystine reductase
51
Identify compounds A and B in the following reaction! 1. A: cystine, B: cysteine 2. A: homocysteine, B: cysteine 3. A: cystathionine, B: cysteine 4. A: cysteine, B: homocysteine 5. A: cystathionine, B: cystine 6. A: cysteine, B: cystine
answer: 1. A: cystine, B: cysteine
52
Identify cofactors A and B in the following reaction! 1. A: NADH + H+, B: NAD+ 2. A: NADPH + H+, B: NADP+ 3. A: tetrahydriobiopterin, B: dihydrobiopterin 4. A: NADP+, B: NADPH + H+ 5. A: NAD+, B: NADH + H+ 6. A: dihydrobiopterin, B: tetrahydriobiopterin
answer: 1. A: NADH + H+, B: NAD+
53
Which enzyme catalyzes the following reaction? 1. methionine adenosyltransferase 2. cystathionine β-synthase 3. methionine synthase 4. cystine reductase
answer: 1. methionine adenosyltransferase
54
Identify compounds A and B in the following reaction! 1. A: methionine, B: S-adenosyl-methinonine 2. A: methionine, B: S-adenosyl-homocysteine 3. A: homocysteine, B:cystathionine 4. A: methionine, B: cystathionine 5. A: homocysteine, B: S-adenosyl-methionine 6. A: homocysteine, B: S-adenosyl-homocysteine
answer: 1. A: methionine, B: S-adenosyl-methinonine
55
Identify compounds A and B in the following reaction! 1. A: ATP, B: Pi + PPi 2. A: ATP, B: AMP 3. A: ATP, B:adenosine 4. A: GTP, B: Pi + PPi 5. A: GTP B: GMP
answer: 1. A: ATP, B: Pi + PPi
56
Which enzyme catalyzes the following reaction? 1. cystathionine β-synthase 2. methionine adenosyltransferase 3. methionine synthase 4. cystine reductase 5. cysteine dioxygenase
answer: 1. cystathionine β-synthase
57
Identify compound A in the pathway below! 1. methionine 2. S-adenosyl-methionine 3. S-adenosyl-homocysteine 4. homocysteine 5. cystathionine 6. cysteine
answer: 1. methionine
58
Identify compound B in the pathway below! 1. methionine 2. S-adenosyl-methionine 3. S-adenosyl-homocysteine 4. homocysteine 5. cystathionine 6. cysteine
answer: 2. S-adenosyl-methionine
59
Identify compound C in the pathway below! 1. methionine 2. S-adenosyl-methionine 3. S-adenosyl-homocysteine 4. homocysteine 5. cystathionine 6. cysteine
answer: 3. S-adenosyl-homocysteine
60
Identify compound D in the pathway below! 1. methionine 2. S-adenosyl-methionine 3. S-adenosyl-homocysteine 4. homocysteine 5. cystathionine 6. cysteine
answer: 4. homocysteine
61
Identify compound E in the pathway below! 1. serine 2. glycine 3. cysteine 4. homocysteine 5. propionyl-CoA
answer: 1. serine
62
Identify compound F in the pathway below! 1. methionine 2. S-adenosyl-methionine 3. S-adenosyl-homocysteine 4. homocysteine 5. cystathionine 6. cysteine
answer: 5. cystathionine
63
Identify compound G in the pathway below! 1. methionine 2. S-adenosyl-methionine 3. S-adenosyl-homocysteine 4. homocysteine 5. serine 6. cysteine
answer: 6. cysteine
64
Identify compound H in the pathway below! 1. α-ketobutyrate 2. propionate 3. α-ketoglutarate 4. oxaloacetate 5. acetoacetate
answer: 1. α-ketobutyrate
65
Identify compound I in the pathway below! 1. propionyl-CoA 2. succinyl-CoA 3. acetoacetyl-CoA 4. butyryl-CoA 5. glutaryl-CoA
answer: 1. propionyl-CoA
66
What is indicated by A and B in the pathway shown below? 1. A: acceptor, B: CH3-acceptor 2. A: NAD+, B: NADH + H+ 3. A: H2O, B: NH4+ 4. A: THF, B: methyl-THF 5. A: THF, B: formyl-THF
answer: 1. A: acceptor, B: CH3-acceptor
67
What is indicated by D and E in the pathway shown below? 1. D: H2O, E: adenosine 2. D: NAD+, E: NADH + H+ 3. D: H2O, E: CO2 4. D: THF, E: methyl-THF 5. D: H2O, E: NH4+
answer: 1. D: H2O, E: adenosine
68
What is indicated by A and B in the pathway shown below? 1. A: NAD+, B: NADH + H+ 2. A: NADP+, B: NADPH + H+ 3. A: ATP, B: ADP 4. A: GTP, B: GDP 5. A: tetrahydrobiopterin, B: dihydrobiopterin
answer: 1. A: NAD+, B: NADH + H+
69
The figure below shows the conversion of methionine to propionyl-CoA. Which one of the following compounds is not an intermediate of the pathway? 1. α-ketoglutarate 2. S-adenosyl-methionine 3. homocysteine 4. cystathionine 5. S-adenosyl-homocysteine
answer: 1. α-ketoglutarate (do no mix with α-ketobutyrate)
70
Identify compound A in the pathway shown below! 1. urea 2. ornithine 3. citrulline 4. fumarate 5. argininosuccinate 6. arginine
answer: 1. Urea