Case-Base Drugs- Fitzakerly

Question 1

MOA Bortezomib

Answer 1

Reversibly inhibits 26S protesasome: leads to actiation of signaling cascades, cell-cycle arrest and apoptosis

G2-M

Question 2

MOA Interleukin 2

Answer 2

Immune system stimulant: cytokine that induces and expands T-cell response

Question 3

MOA of lenalinomide/ Thalidomide

Answer 3

TNF-alpha inhibitor (most potent) = prevents angiogenesis

Also increases IL-2, IFN gamma, induces cell cycle arrest and cell death

Question 4

MOA melphalan

Answer 4

Alkylating agent-crosslinking DNA strands

Question 5

MOA of 6-Mercaptopurine

Answer 5

Prevent DNA synthesis: block puring synthesis- “pseudofeedback inhibition” of PNP and PRPP

S-phase specifi

Question 6

Cytokine-induced killer cell CIK therapy

Answer 6

provoke adaptive immune response: upregulate NK cells and T-cellls

Question 7

What is the difference between CIK and LAK?

Answer 7

CIK (cytokine induced killer) = provoke adaptive immune response, increase cytotoxic t-cells

LIK (lymphokine induced killer)= provoke innate immune response, increase in Natural killer cells