case 5 Flashcards
GAD
6 months of persistent anxiety without cause. anxiety about a wide range of issues rather than a specific event like phobia, free floating not linked to a cause. more common in females. 1/20, 20yr. projections from amygdala to PAG and diffuse modulatory result in anxiety, projections to hypothalamus maintain state of anxiety. hippocampus inhibits CRH release, can become saturated and die, benzodiazepines/SSRIs first line treatment
signs and symptoms
psychological symptoms-worry, dread, poor conc, irritability
physical symptoms-trembling, nausea, shortness breath, headaches, irritability, sleep, restless.
behavioural symptoms-putting things off, avoidance, drug taking. 6/12 in ICD10. last longer than 6 months.
aphasia
inability to speak write or understand spoken or written work from a lesion to brain. sensory, motor, conductive, global.
wernikes
found in superior temporal gyrus identify and comprehend words that are performed.
circuit for spoken language
- When a person hears a sentence, this is transmitted via the auditory apparatus to the primary auditory cortex in the temporal lobe.
- This then connects to Wernicke’s area, which decodes the language into meaning.
- If the sentence is to be repeated, or replied to, the information has to be transmitted forwards to Broca’s area (expressive speech) in the frontal lobe (via the arcuate fasciculus).
- Broca’s area then produces speech via the motor programmes of the motor cortex, which activate the tongue and laryngeal muscles.
circuit for understanding written language
- Visual input is transmitted to the visual cortex in the occipital lobe.
- Input from the visual association area is sent to the left angular gyrus, where the objects are recognized and named.
- Input then goes to Wernicke’s area, where words are assembled into sentences, and the appropriate messages are sent via the arcuate and superior longitudinal fasciculi to Broca’s area.
test for CN I
olfactory. occlude one nostril, different smells. eyes closed. ask strength of smell.
CN II
optic. snellen chart one eye at a time-visual acuity. visual fields, look at me, cover one eye, say now when can see. 8 times per eye. Opthalmoscope-Optic disc, fovea, pupil reactions rate of reflex, look ahead. into distance then at finger. accomodation.
CN III
occulomotor. pupillary light reflex. H test up down and medially. ask if double vision. hold head.
CN IV
trochlear, superior oblique, H test down and medial.
CN V
trigeminal. muscles mastication-masseter whilst bite, open against resistence, temporalis whilst bite, side to side against resistence. sensation of face sharp or dull. first on clavicle. corneal reflex
CN VI
abducens-lateral rectus H test laterally
CN VII
facial. raise eyebrows, blow cheecks, prize lips or eyes open taste ant 2/3.
CN VIII
vestibulocochlear- rienne and weber test. distract one ear whilst say something in other. hearing machine for frequencies heard.
CN IX
glossopharyngeal-gag, taste post1/3 say aahh inspect palate
CN X
vagus-swallow, speak, say aahh,
CN XI
accessory-raise trapezius and SCM
CN XII
hypoglossal-stick out tongue move side to side. see if twitch.
recovery after brain injury
.axonal sprouting-formation new connections in cortex. Neurogenesis-formation new neurons. Angiogenesis-new blood vessels. Growth factor regulation such as FGFs and EPO to promote erecovery. Oligodendrocyte precurser cells. hypoexcitability.
neuroplasticity
cellular changes and cortical remapping. ability to learn and modify. strongest in childhood. children recover from stroke better as brains still developing plastic state make circuit connections needed to repair. synaptic pruning-weaker connections are eliminated whilst stronger ones are strengthened.
lower motor neurons
those that innervate the arms are in the cervical enlargement those that innervate the leg aer in the lumbar enlargment. spinal cord segments that innervate a large amount of muscles have a swollen ventral horn. Directly innervated by local circuit in SC or CS, or indirectly in higher centres. Y fibres regulate sensory input to set intrafusal muscle fibre length.
damage is loss of reflex, paralysis, loss muscle tone, atrophy, fibrillations.
lateral spinothalamic tract
pain and temperature. nerve cell body of 1st order neurons in dorsal root ganglion. terminate in dorsal horn. deccusate, ascend in contralateral lateral spinothalamic tract, pass through spinal lemniscus and terminate in VP nucleus of thalamus. Third order neurons project to somatosensory cortex.
ventral spinothalamic tract
crude touch and pressure. NCB in dorsal root ganglion. terminate in dorsal horn. asend segments before decussating then ascend in contralateral spinothalamic tract, pass in spinal lemniscuc and terminate in VP nucleus of thalamus. Third order neurons to somatosensory cortex.
dorsal columns
proprioception, discriminative touch and vibration. gracilis from lower limb. cell bodies in dorsal root ganglion, ascend in ipsilateral sorsal column to the medulla. axons in fasciculus gracilis terminate in cucleus gracilis etc. second order neurons deccusate and ascend in medial lemniscus terminate in VP of thalamus. third order neurons project to somatosensory cortex.
ascending pathways of the head-trigeminothalamic pathway
first order neurons synapse in trigeminal nucleus-mesencephalic propriception. chief touch and pressure. spinal pain and temperature. facial glossopharyngeal and vagus nerve also convey some general sens info from head and neck. second order neurons deccusate and ascend in contralateral trigeminothalamic tract, terminate in VP nucleus of thalamus. third order go to somatosensory cortex of postcentral gyrus. parietal lobe.