Cartilage Flashcards
Does cartilage have a blood supply ?
NO it is avascular
Where is cartilage found /
areas of support and movement
condrocytes
large rounded cells with LIGHT cytoplasm and small nuclei which produce matrix
matrix
firm, high in glycosaminoglycans (GAG’s) and hyaluronic acid
What are the three types of matrix
hyalin cartialge
elastic cartilage
fibrous cartilage
What is the function of hyalin cartilage ?
it binds bones together, for joints because it has low friction
synchondrosis
bondage of bones
What type of fibers does hyalin cartilage have ?
type II collagen
Can you stain cartilage with H ad E ?
no because i is in the form of fibrils and its refractive index is the same as the ground substance
Cavities in the matrix of hyalin cartialge are called what
lacuane and they are for chondrocytes
Where do chondrocytes originate from
mesenchymal cells
Appearance of chondroblasts
basophilic cytoplasm, synthesize ECM do NOT aggregate in clusters
where are chondroblasts found
growing cartilage
chondrocytes
inactive cells have light cytoplasm
isogenous groups
recently divided chondrocytes that are sitting in clusters in the lacuane surrouned by a territorial matrix and an interterritorial matrix
Is the territiroial high or low in GAG’s
high
is the interterritorial matrix high or low in GAGS
low
what is perichondrium
collagenous membrane on the surface of cartilage that carries vessels and nerves (essential for the avascular cartilage
What are the two layers of perichondrium
outer fibrous layer of dense connective tissue and an inner chondrogenic layer of mesenchymal cells
When is perichondrium NOT present
when cartilage contacts with bone; articular surfaces
Characteristics of Elastic Cartilage
elastic fibers in matrix
stains with resourcin-fuchsin or orcein
found in ears, cartilages of larynx
does NOT calcify with aging
What are the characteristics of Fibrocartilage
combination of dense regular connective tissue and hyaline cartilage
chondrocytes are sitting in rows
large amt of collagen
no perichondrium
Appositional growth
chondroblasts are formed by the inner layer of perichondrium (type 1 collagen) and they produce matrix (collagen type 2) and turn to chondrocytes
interstitial growth
division of chondrocytes within the lacunae-isogenous groups
