Blood Flashcards
What is the function of the blood ?
transport of oxygen transport of co2 delivery of regulatory substances buffer function immune function
99 percent of blood is composed of what
erythrocyte and reticulocytes
hematocrit
percentage of the volume of cellular elements vs. total volume
Blood plasma is contains 91 percent water and 7-8 percent protein, what makes up this protein portion
albumin, gamma globulins and alpha, beta golbulins and fibronogen
erythrocytes
anucleate eosinophilic cells devoid of typical organlles
biconcave disc
bind oxygen and carbon dioxide
What is the life span for a erythrocyte
120
What are RBC’s broken down
spleen, bone marrow and liver
What is the membrane of the erythrocyte
lipid bilyer
integral membrane proteins
peripheral membrane proteins
hemoglobin function
transport oxygen and carbon dioxide
Structure of hemoglobin
4 polypeptide subunits
each one contains a heme
4 different types of globin chains
sickle-cell anemia
caused by a single point mutation in the gene that encodes a beta globin chain of hemoglobin A, sickeled erythrocytes are more rigid and tend to pile up in the capillaires
What are the 3 types of granulocytes
neutrophils
basophils
eosinophils
What are the 2 types of agranulocytes
lymphocytes and monocytes
what are the two types of leukocytes
granulocytes and agranulocytes
characteristic of neutrophils
migration named after lack of cytoplasmatic staining multilobed nuc heterochromatin in periphery granules
What are the types of granules in neutrophils
specific granules
axurophylic granules (primary)
tertiary granules
azuropylic granules of neutrophils
larger granules, lysosomes containing myeloperoxydase that generates bactericidal hypochloride; cationic proteins called defensins that have bactericidal function
secondary granules of neutrophils
smallest, most numerous contain enzymes (4 collagenase, phospholipidase); complement activators, bactericidal agent
tertiary granules of neutrophils
phosphatase containg and metalloproteise (facilitates migration through connective tissue)
eosinophils
bilobed nucleus
heterochromatin in periphery
euchromatin in middle of nucleus
have specific crnaules-cristalloid body and granule matrix and also have azurophylic granules (lysosomes containing acid hydrolases)
cristalloid body
MBP-acidophilia of granule cytotoxic to protozoans and hlemintic parasites(found in eosinophils)
granule matrix
found in eosinophils have ECP, EPO, and EDN as well as a lot of other things such as histaminase and arylsulphatase
azurophylic granules
lysosomes containg hydrolytiic enzymes
basophils
bilobed nucleus obscured by granules
heterochromatin in periphery of nucleus
grainy texture to granules
plasma membrane posses fc receptors for IgE and expresses CD40L
