Cardiovascular S+H Flashcards
Primary trigger for activation of RAAS in CV disease
Heart unable to provide adequate renal blood flow
Which hormone is released by the macula dense when there is decreased renal perfusion and sodium delivery to the distal portions of the nephron
Renin
Renin converts _____ to ____
Angiotensinogen to angiotensin I
Angiotensin converting enzyme (Ace) converts ____ to ____
Angiotensin I to angiotensin II
Chronic SNS activation leads to
Adrenergic receptor down regulation
Persistent tachycardia
Increased myocardial oxygen demand
Myocyte necrosis
What are the two main hormones that induce natriuresis, diuresis, and vasodilation?
Atrial natriuretic peptide and brain natriuretic peptide (ANP and BNP)
What induces production of ANP and BNP
Myocardial stretch/stress
Endothelin I causes ____ and is released by vascular endothelial cells in response to ____
Causes vasodilation
Released in response to shear stress, angiotensin II, and other various cytokines
Together with ____, endothelin I causes vasoconstriction and increased cardiac after load
Angiotensin II
In addition to its vascular effects, endothelin I alters normal ___ cycling within muscle cells and is directly toxic to ____
Alters normal calcium cycling within muscle cells and is directly toxic to cardiac myocytes
Arginine vasopressin, or ADH, is released in response to stimulation of ____ in response to decreased intravascular pressure
Stimulation of the baroreceptors in the aortic arch and carotid
Dilutional hyponatremia indicates ____
Excess free water and dilution of sodium despite entire body stores of sodium being elevated
Concentric hypertrophy is in response to increased ____ such as with _____
Increased pressure load
Increased after load - systemic hypertension, SAS
Increased after load triggers replication of _____ in parallel resulting in a relative increase in ___ of the ventricular wall
Sarcomeres
Increase in relative thickness
Conversely, in situations of volume overload (i.e. mitral regurgitation), the sarcomeres replicate in _____ which results in elongation of the myocytes and dilation of the ventricle.
In series (end to end)
Eccentric hypertrophy
Consequences of concentric hypertrophy
Increased myocardial oxygen demand, endocardial ischemia, fibrosis, collagen disruption, injury to small coronary vessels
Consequences of eccentric hypertrophy
Increased myocardial wall stress, myocyte injury and necrosis, and myocyte slippage
Main storage area of calcium in the heart muscle cells
Sarcomplasmic reticulum
During systole, calcium ions ____ which triggers release of additional calcium from the SR
Calcium ions enter the myocardial cell and trigger release of additional calcium ions from the SR
Channel that calcium flows through
Ryanodine channel
Calcium flows through the ryanodine channel and binds to _____
Troponin C located on the actin-myosin complex
What initiates the cascade of events that lead to sarcomere contraction
Calcium binding to troponin C
Once contraction is complete, calcium is released from troponin C and travels back to the SR via the _____ channel
Sarcomplasmic/endoplasmic reticulum Ca-ATPase (SERCA) channel
Another effector molecule in the cytoplasm that helps regulate calcium reuptake
Phospholamban
Myocyte mitochondria provide high-energy _____ molecules that fuel calcium and other ion pumps
Phosphate molecules
In dogs with myocardial disease, the _____ chain located within mitochondria lack critical cytochromes and enzymes needed for energy production
Oxidative phosphorylation chain
The heart can utilize ___ and ___ as its main substrates for energy production
Glucose and fatty acids
In cases of heart failure, the heart preferentially uses ___ which requires less oxygen to metabolize than ___
Preferentially uses glucose over fatty acids
Pulmonary venous pressures greater than ____ and systemic venous pressures >____ typically result in congestion
> 25 mmHg pulmonary venous
20 mmHg systemic venous
Why are dogs at less risk for coronary artery disease than humans
Extensive epicardial network of collateral vessels
In dogs with atherosclerosis, what are predisposing factors
Hypothyroidism
Hyperlipidemia
Hypercholesterolemia
HYPERCOAGULABILITY
In a case report of six dogs with snake envenomation, sepsis and SIRS, what ECG abnormality was seen associated with myocardial infarction?
Transient deep and negative T waves
During skeletal and cardiac muscle relaxation, ____ blocks the binding sites on actin
Tropomyosin
Once intracellular calcium levels rise and ATP is present, calcium will bind to ____, displacing it from tropomyosin allowing exposure of myosin binding sites on actin
Troponin
Three distinct proteins associated with troponin complex
I, T and C
Which two troponin play a role in diagnosis of myocardial injury, particularly infarction
I and T
Troponin T (cTnT) is present in four isoforms, of which only ____ is expressed in adults
One
Troponin I (cTnI) is present in three isoforms, with only ____ found in cardiac muscle
One
cTnI is/is not expressed in fetal tissue
NOT
_____ is inhibited by cTnI and thereby prevents interaction with myosin and actin binding sites
Actomyosin ATPase
When calcium binds to ____, ___ is displaced and a conformational change of tropomyosin results, allowing muscle contraction
When calcium binds to troponin C, cTnI is displaced and a conformational change of tropomyosin results, allowing muscle contraction
The majority of troponin is bound within _____ but a small amount is free in the cytosol
The thin filaments
When cardiac myocytes becomes damaged, ___ becomes released into circulation
Troponin
Circulating troponin increases ____ hours after injury with peak values occurring _____ after onset of symptoms, which can last up to ____ days
Increase 2-4 hours after injury
Peak in 18-24 hours
Can last up to 14 days
What other diseases can result in troponin elevation
Renal disease, sepsis, trauma, extreme exercise, infectious disease, inflammatory disease
In order for wall motion to be abnormal/segmental wall abnormality to be detected on echocardiogram, >____% of the myocardial wall must be affected
> 20%
____ foci have also been detected on echo and suggest myocardial infarction
HypERechoic foci within the myocardium
Vipera berus envenomation in dogs- ECG abnormalities and cTnI levels
All dogs survived. Twelve dogs (57%) developed arrhythmias, all of which were ventricular in origin. Severe complex ventricular arrhythmias (VAs) were observed in 6 dogs (29%). Eighty-one percent of dogs (n = 17) had increased cTnI concentrations at 1 or more time points. Dogs that developed arrhythmias had signifi- cantly higher concentrations of cTnI at 12 hours (1.67 [0.04-32.68] versus 0.03 [0.01-0.052]; P = .002), 24 hours (1.88 [0.2-14.23] versus 0.06 [0.01-2.06]; P = .009), and 36 hours (3.7 [0.02-16.62] versus 0.06 [0.01-1.33]; P = .006) after bite compared to those that did not.
Troponin and CRP levels in dogs with various snake envenomations
Concentrations of cardiac troponin I (cTnI), a marker of myocardial injury, and C-reactive protein (CRP), a marker of systemic inflammation, were measured in each blood sample. Evidence of myocardial injury was found in 58% of dogs envenomed by V. berus at one or more time points. A significant correlation between cTnI and CRP concentrations was found at all time points. Evidence of myocardial injury was found in 80% of dogs envenomed by B. arietans at one or more time points; however, no correlation was found between cTnI and CRP concentrations. Evidence of myocardial injury was found in 67% of dogs envenomed by N. annulifera at one or more time points. A significant correlation between cTnI and CRP concentrations was found at admission, but not at other time points.
Transient deep and negative T waves in dogs with myocardial injury (2021)
Six cases were diagnosed with MI associated with deep (n = 1) and giant (n = 5) transient NTWs. Myocardial injury was classified as acute in all cases and was due to snake envenomation (n = 3), sepsis (n = 2), and systemic inflammatory response syndrome (n = 1). At the time of deep/giant NTWs identification, all dogs had elevated cardiac troponin I and ≥1 echocardiographic abnormality of the left ventricular structure and/or function. Moreover, all dogs with giant NTWs had prolonged QT intervals. After the MI resolution, T-wave polarity and QT-interval duration became normalized in all dogs. Moreover, left ventricular morphological and functional parameters were completely normalized in four dogs. In contrast, ventricular echogenicity remained heterogeneous in two dogs, despite otherwise normalized ventricular parameters. Five dogs were still alive at the conclusion of the study.
Five cardiomyopathy phenotypes
- Hypertrophic
- Dilated
- Restricted - end-myocardial restrictive, myocardial restrictive
- ARVC
- Non-specific/unclassified
Characteristics of HCM
Segmental or diffuse left ventricular wall thickening
Sequela of HCM possible
CHF
Arterial thromboembolism
Ventricular arrhythmias +/- sudden death
Supraventricular arrhythmias
Normal lifespan possible
Characteristics of DCM
Primary reduction of left ventricular systolic function with normal or reduced LV wall thickness, and eventual LV and LA dilation
Potential sequela of DCM
Arterial thromboembolism
CHF
Ventricular arrhythmias +/- sudden death
Supraventricular arrhythmias
Normal lifespan UNLIKELY
Endomyocardial restrictive cardiomyopathy characteristics
Endocardial scar bridging the left ventricular septum and free wall with associated LA or biatrial enlargement
Characteristics of myocardial restrictive cardiomyopathy
Left or biatrial enlargement with normal LV dimensions
Sequela of restrictive cardiomyopathy
Arterial thromboembolism
CHF
Ventricular arrhythmias +/- sudden death
Supraventricular arrhythmias
Normal lifespan UNLIKELY
Characteristics of ARVC
Severe dilation of right heart with right ventricular systolic dysfunction and myocardial thinning
Sequela of ARVC
Right sided CHF
Ventricular and supra ventricular arrhythmias common - may cause sudden death
PULMONARY thromboembolism
Characteristics of non-specific cardiomyopathy
Any phenotype not fitting the others
Concomitant/underlying disease states contributing to feline cardiomyopathy phenotypes
Hypertension - HCM
Neoplastic myocardial infiltration - HCM
Transient myocardial thickening - HCM
Inflammatory myocardial infiltration - HCM
Acromegaly - HCM
Hyperthyroidism - HCM, RCM, UCM
Taurine deficiency - DCM
Chronic tachycardia - DCM
Suspected underlying mechanism of genetic HCM
Sarcomeric mutations involving either thick (myosin) or thin (actin) filaments causing a hyper contractile cardiac sarcomere
Genetic mutations detected predisposing cats to HCM
Two mutations in one gene (myosin binding protein C, MYBP3) - the A31P mutation in Maine Coon cats, and the R820W in Ragdolls
Most common complication of HCM and percentage of development
CHF, 23.9%
Approximately what percentage of cats with HCM develop ATE
~11%
Embolism to the right ____ artery can affect the front limbs
Brachial artery
The primary arterial occlusion results in release of vasoactive substances from activated platelets, such as ____, which results in vasoconstriction of collateral arteries
Serotonin