ALI/ARDS

Question 1

T/F: ALI/ARDS is a severe inflammatory process at the level of the lung which occurs secondary to a catastrophic event

Answer 1

True

Question 2

ALI/ARDS is clinically characterized by

Answer 2

Acute onset dyspnea and hypoxemia
Non-cardiogenic pulmonary edema (diffuse endothelial and epithelial injury)

Question 3

Criteria for diagnosis of ARDS in HUMANS- Berlin:

Answer 3

Timing: new or worsening respiratory symptoms within one week of insult
Chest imaging: bilateral infiltrate, not fully explained by effusions, lobar/lung collapse, or nodules

Oxygenation:

Mild: 200 < P:F </= 300 with PEEP or CPAP >/= 5 cm H2O
Moderate: 100 < P:F </= 200 mmHg with PEEP >/= 5 cm H2O
Severe: P:F </= 100 mmHg with PEEP >/= 5 cm H2O

Question 4

What are the three main phases of pathogenesis of ARDS

Answer 4

Exudative phase
Proliferative phase
Fibrotic phase