Cardiovascular - Part 2 Flashcards
Describe the MOA of diuretics (2)
- Accelerate urine formation
- Vasodilation
______ are the first line therapy for hypertension
Diuretics
What results from inhibition of water and sodium from reabsorption?
Increased diuresis / potency
Potency of diuretics depends on …
The area of the nephron affected
Describe the nursing assessments associated with diuretics (6)
- Baseline fluid volume
- Daily weights / I & O
- Renal function
- Electrolytes
- Urine
- BP
Describe the general side effects associated with diuretics (5)
- Hypokalemia
- Hyponatremia
- Hypomagnesmia
- Hyperuricemia
- Dehydration –> hypotension
What is the drug class of furosemide (Lasix)?
Loop diuretic
Where does the MOA of furosemide (Lasix) occur?
Ascending loop of Henle
Describe the MOA of furosemide (Lasix)
Sodium / chloride / potassium excretion
furosemide (Lasix) decreases ______
Preload
furosemide (Lasix) is known as a ______ diuretic
Potassium-wasting
It is important to consider ______ when giving loop diuretics
Route
What are the routes of furosemide (Lasix)? (2)
- PO
- IV
What is the drug class of hydrochlorothiazide (HCTZ)?
Thiazide diuretic
hydrochlorothiazide (HCTZ) is known as a ______ diuretic
Potassium-wasting
Where does the MOA of hydrochlorothiazide (HCTZ) occur?
Distal convoluted tubule
Describe the MOA of hydrochlorothiazide (HCTZ)
Sodium / chloride / potassium excretion
hydrochlorothiazide (HCTZ) decreases ______
Afterload
hydrochlorothiazide (HCTZ) causes ______
Osmotic water loss
______ allergy is a contraindication of hydrochlorothiazide (HCTZ)
Sulfa
Efficacy of thiazide diuretics decreases with ______
Poor renal function - hold if creatinine is < 30
Describe the education associated with potassium-wasting diuretics
Consume potassium-rich foods
What are the manifestations of hypokalemia? (5)
- Anorexia
- Lethargy
- Nausea
- Hypotension
- Weakness
What ECG changes indicate hypokalemia? (2)
- U-waves
- T-wave inversion
spironolactone (Aldactone) is known as a _______ diuretic
Potassium-sparing
Where does the MOA of spironolactone (Aldactone) occur? (2)
- Distal convoluted tubules
- Collecting ducts
Describe the MOA of spironolactone (Aldactone) (2)
- Sodium / water excretion
- Inhibits aldosterone
What are the indications of spironolactone (Aldactone)? (2)
- Ascites
- Hyperaldosteronism
What are the contraindications of spironolactone (Aldactone)? (2)
- Hyperkalemia
- Adrenal insufficiency
What is the primary interaction associated with spironolactone (Aldactone)?
ACE inhibitors - risk of hyperkalemia
Hold potassium-sparing diuretics if potassium level is ______
> 5