Cardiovascular disease Flashcards

1
Q

What is most cardiovascular diseases related to

A

Blood vessels, not heart

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is major cause of death in US

A

Heart disease - 26.6%

Stroke = 5.9% = 3rd

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the cardiovascular diseases?

A
  • Pericarditis
  • Valve defects
  • Defects in the specialised excitatory and conductive system
  • Hypertension - high b.p
  • Assorted congenital heart defects
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is Pericarditis

A

Inflammation of pericardium
Acquired disease
Won’t kill you but lead to conditions that might kill you
Fluid pericardium produces too much pressure on heart or too little - heart beating in envionment with not enough lubrication = heart function less efficiently

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the two types of valve defects

A

Stenosis
Regurgitation
= valves not opening enough - too narrow = blood flows back down heart

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What involves heart not functioning properly

A
  • Wont beat properly
  • Won’t push out as much blood
  • Disrupt normal rhythm
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the 3 defects in the specialised excitatory and conductive system

A
  • Tachycardia and Bradycardia - heart beat too slow/fast
  • Ventricular fibrillation - heart high frequency contractions
  • Ectopic pacemaker - another part of system takes over
  • Heart block - break in B.Of.His
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What does specialised excitatory and conductive system allow

A

Heart maintain regular contraction without input from nervous system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the assorted congential ( born with ) heart defects?

A
  • Septal defects
  • Development of single ventricle
  • Contraction of aorta (narrowing)- if blood vessels too big, it will press on blood vessels underneath- causing narrowing
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is Septal defect

A

(Hole in heart)- oxygenated and deoxygenated blood mix between 2 ventricles - sometimes hole doesnt completely close between left and right ventricle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is contraction of aorta as defect

A

If blood vessels too big, it will press on blood vessels underneath- causing narrowing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the structure of blood vessels - 3 broad categories

A

Veins
Arteries
Capillaries

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What do veins and arteries act as

A

Pipes - take blood from A - B, no gas exchange
Veins- bring blood to the heart
Arteries- take blood from the heart

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Role of capillaries

A

Gas and nutrient exchange

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the 3 layers of the arteries

A

Tunica Interna
Tunica Media
Tunica Externa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the role of tunica interna

A

It provides a frictionless surface for the movement of blood - so you dont get blood clotting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What are the endothelial cells?

A
  • are continuous with heart

- have smooth frictionless lining for both blood vessels and heart

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Location of the endothelial cells?

A

sits on the basement membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is the role of internal elastic lamina?

A

separates the tunica interna from the tunica media

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is the inner layer of a blood vessel?

A

Tunica interna

simple single squamous epithelium, sitting on a basement membrane, surrounded by internal elastic lamina

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What is the bulk of the artery - middle layer ?

A

Tunica Media

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

How many layers are arteries made up of

A

3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What are arteries mostly made of

A

Mostly muscular
up to 40 layers of smooth muscle
some elastic and collagenous connective tissue.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Which arteries are close to heart

A

Big arteries - aorta

Elastic/conducting arteries with elastic properties

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Which arteries are further down from heart

A

Smaller arteries and capillaries

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

What can the tunica media be innervated by

A

The sympathetic branch of the ANS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

What supplies the tunica media and externa of larger vessels

A

Vaso Vasorum

Blood vessels in blood vessels -have vessels in their walls called Vasa Vasorum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

How do different arteries vary

A

In the thickness and composition of various layers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

What is it internal elastic lumina

A

Elastic layer of connective tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

How often does tunica interna turn over

A

At a rate of 5% of endothelial cells a day

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Two properties of the endothelial cells

A
  • Sits on basement membrane

- Continuous with heart, smooth frictionless lining of blood vessels and heart

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

What don’t elastic arteries have so much of

A

Have little smooth muscle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

Why are arteries elasticated

A

Allows them to smooth out the blood flow near the heart

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

What happens to arteries when heart contracts

A

Blood pushed into these arteries and gets bigger - dilate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

What happens to arteries when heart relaxes

A

Due to their elastic properties, they collapse down which evens out pressure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

What do muscular arteries have a tunica media composed of and what is role

A

Primarily smooth muscle

Distribute blood and change diameter

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

What do elastic ( conducting ) arteries have a tunica media composed of

A

Elastic tissue laminae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

What is tunica media mostly made of

A

Concentric layers of smooth muscle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

What don’t you want muscles in blood vessels to do

A

To contract and squeeze or move blood along

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

What do you want muscles in blood vessels to do

A

To make blood vessels wide and narrow to regulate b.p = redirect blood
Close blood vessels down if it gets injured
Close down circulation in bits of body when its cold = close down blood supply to finger and toes = gets cold outside to keep up core temp

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

What else does the tunica media have?

A

Nerve supply to artery- sympatheic NS innervates smooth muscle of most arteries

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

What does the tunica media mostly have

A

Smooth muscle and collagenous elastic connective tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

What can’t you do if you have a big artery

A

Supply tunica media from blood in lumen of vessel so big vessels have vessels in their walls = vasa vasorum - vessels of vessels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

What is the role of external elastic lumina

A

Separate tunica media from tunica externa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
45
Q

What is the outer layer of artery called and what is it made of

A

Tunica externa AKA Adventitia - several layers of longitudinal colagenous connective tissue = tough outerprotective coat

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
46
Q

What does recoil of arteries help to do

A

Push blood along

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
47
Q

What does contracting and relaxing of smooth muscle of tunica media do

A

Distribute blood to different organs and regions of body

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
48
Q

Where are muscular arteries found

A

Further down system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
49
Q

What is different about these elastic arteries?

A
  • They dont have that much smooth muscle in the tunica media

- Mainly have elastic tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
50
Q

What are the arteries closest to the heart known as?

A

Elastic/conducting arteries (with the same 3 layers)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
51
Q

What is diameter of arterioles

A

Small diameter = less than 0.5mm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
52
Q

What is role of arterioles

A

Regulate bp

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
53
Q

What do arterioles consist of

A

Endothelium with a bit of rings of smooth muscle cells around them

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
54
Q

What dont arterioles have

A

3 coats or layers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
55
Q

What is diameter, length and total surface area of capillaries

A

Small diameter = 7-9 um
length= 0.25-1mm
Total length in body = 96,000km with surface area 6000m2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
56
Q

How are arterioles linked to venules

A

By extensive capillary beds

57
Q

What are two things that capillaries have

A

Endothelium

Basement membrane

58
Q

What does distrubution of capillaries depend on and example

A

Tissue
e.g. skeletal muscle have lots of capillaries as it uses lots of O2, cornea have no capillaries and tendons little capillaries

59
Q

Role of capillaries

A

Exchange of nutrients and respiratory gases

60
Q

How many miles of capillaries in body

A

60,000

61
Q

What are the two main types of capillaries

A

Continuous

Fenestrated

62
Q

Continuous capillaries

A

Adjacent endothelial cells (which sit on the basement membrane) are joined by tight junctions.
The exchange of nutrients go through the cells called Pinocytic vesicles

63
Q

Fenestrated capillaries

A

60-100nm
Lots of pores covered by a thin membrane over it.
It is for the rapid exchange of nutrients
e.g eye= behind retina, within the ciliary body you have a lot of fenestrated capillaries

64
Q

how do you control capillary blood flow?

A

Rings of smooth muscle= Pre- capillary sphincter

  • When they contract, they stop blood from going to capillary bed
  • the blood will go straight from the arteriole to the venule
  • Deoxygenated blood ends up in the venule
65
Q

What is different about these elastic arteries?

A
  • They dont have that much smooth muscle in the tunica media

- Mainly have elastic tissue

66
Q

What are the arteries closest to the heart known as?

A

Elastic/conducting arteries (with the same 3 layers)

67
Q

What is diameter of arterioles

A

Small diameter = less than 0.5mm

68
Q

What is role of arterioles

A

Regulate bp

69
Q

What do arterioles consist of

A

Endothelium with a bit of rings of smooth muscle cells around them

70
Q

What dont arterioles have

A

3 coats or layers

71
Q

What is diameter, length and total surface area of capillaries

A

Small diameter = 7-9 um
length= 0.25-1mm
Total length in body = 96,000km with surface area 6000m2

72
Q

How are arterioles linked to venules

A

By extensive capillary beds

73
Q

What are two things that capillaries have

A

Endothelium

Basement membrane

74
Q

What does distrubution of capillaries depend on and example

A

Tissue
e.g. skeletal muscle have lots of capillaries as it uses lots of O2, cornea have no capillaries and tendons little capillaries

75
Q

Role of capillaries

A

Exchange of nutrients and respiratory gases

76
Q

How many miles of capillaries in body

A

60,000

77
Q

What are the two main types of capillaries

A

Continuous

Fenestrated

78
Q

Continuous capillaries

A

Adjacent endothelial cells (which sit on the basement membrane) joined by tight junctions.
The exchange of nutrients go through the cells called Pinocytic vesicles = how nutrients get in and out of capillary

79
Q

Fenestrated capillaries

A

60-100nm
Lots of pores covered by a thin membrane over it.
It is for the rapid exchange of nutrients
e.g eye= behind retina, within the ciliary body you have a lot of fenestrated capillaries for exchange of nutrients

80
Q

how do you control capillary blood flow?

A
  • Rings of smooth muscle= Pre- capillary sphincter - when they contract, they stop blood from going to capillary bed. The blood will go straight from the arteriole to the venule
  • Deoxygenated blood ends up in the venule
  • Shut down capillary beds by contraction of pre - capillary sphincter
81
Q

What is the structure of the vein/venule?

A
  • Diameter= 0.2-1mm
  • Thin walls - vein- see blood through them
  • Consist of endothelium and tunica externa
  • Larger lumen than arterioles but thinner walls = appear darker, see blood through them
  • Tunica media and interna is reduced/thinner= much less smooth muscle
  • Tunica externa= thicker
  • Same 3 tunics as arteries
82
Q

How do the blood vessels appear in the fundus of the retina?

A
  • Veins = darker- due to their thinner walls
  • Artery- lighter - big thick walls
  • Also arteries cross over veins = arteries lie near vitreous, sometimes squashing them
  • Usually arteries on top of veins
83
Q

How does blood pressure vary between the veins and arteries?

A

Veins have low B.P as they are further from heart so less variation = veins have valves to help fight gravity.
Arteries have a higher pressure than in veins.
In the vena cava there’s no pressure at all because its further from heart - all vessels elastic and less variation

84
Q

What are the properties of the veins in the leg?

A
  • Veins have valves in them = prevent backflow
  • pushes blood up the veins when heart contracts
  • when heart relaxes, blood flows down veins and valves shut
  • Skeletal muscle of the leg (muscle around blood vessel)- contract and help squeeze blood up the veins
85
Q

What are varicose veins?

A

When valves break down ( malfunction ) in veins = pooling of blood
Valves seize to function properly and blood accumulate

86
Q

What causes varicose veins

A
  • Any condition that puts excessive pressure on the legs or abdomen = downward pressure on veins and vessels
87
Q

Who is most vulnerable to varicose veins

A

pregnancy, obesity, standing up for long periods

88
Q

What is an example of a pathology of veins

A

Varicose veins

89
Q

What is a main disease of blood vessel?

A

Artherosclerosis (atheroma)

90
Q

What is artherosclerosis?

A
  • deposition of fibrous growths (plaques) within the tunica interna of arteries
  • causes heart attack,stroke
  • Loss of elasticity of blood vessels
  • depositing on blood vessels (mainly arteries) of dense fibrous PLAQUES - nearly completely closed down artery
91
Q

What is artherosclerosis responsible for

A

50% of all mortality in the USA, Europe and Japan

92
Q

What is senile artherosclerosis

A
  • Loss of elasticity of blood vessels in older people - atheroma is a form of this
93
Q

What is artherosclerosis plaque

A

Deposition of dense fibrous plaques in the blood vessels walls

94
Q

How does atheroma form?

A
  1. Inside of blood vessel gets damaged i.e. injury to blood vessel wall- endothelium damaged due to high B.P, hypertension, smoking, virus
  2. Damaged endothelial cells release chemotactic factors (|chemical signals) that signal to repair it
  3. Lead to the accumulation of LDL from the plasma which oxidise LDL and cholestrol
  4. LDL deliver cholesterol to tissues
  5. Macrophages ( WBC ) engulf oxidised lipotproteins and cholesterol and form cells called FOAM CELLS which are yellow. They cause the formation of a fatty ‘yellow streak’ in the vessels tunica interna which is a combination of cholestrol, LDL and proteins being oxidised
  6. Smooth muscle migrates from tunica media to tunica interna to prevent more damage. Migrated smooth muscle cells replicate and produce collagenous connective tissue
  7. Calcium deposits from blood plasma are formed and infiltration of WBC
  8. Lump in tunica interna and tunica media starved of oxygen and scar tissue forms
  9. Blood vessel lumen decreased
95
Q

What contributes to atheroma

A
male and over 40
overweight
no excerise
diet
stress
alcohol 
smoking
diabetes
oral contraceptives
genetics
96
Q

What is biggest contributor to heart disease

A

Smoking

97
Q

What is meant by artiology

A

Factors associated with….

i.e what contributes to it

98
Q

What are the consequences of atheroma

A
  1. smaller blood vessels may become blocked
  2. plaques may become the site of thrombosis
  3. a piece of plaque become detached and form an embolism
  4. a plaque can be the site of aneurysm
99
Q

What % of American 10-14 year olds already had a fatty streak of atheroma

A

40

100
Q

Consequence of atheroma -smaller blood vessels may become blocked

A

Arteries become narrowed and blood flow decreases in atherosclerosis - not that possible in larger arteries
Tissue may not get enough O2

101
Q

what is thrombosis ?

A

When a blood clot forms on atheroma plaque = blood clot in unbroken vessel = more likely

102
Q

why is it unusual to get blood clot in vessels?

A

.Smooth endothelium giving you smooth frictionless flow of blood
.Blood clot will only occur if flow of blood is turbulent = thrombosis = may block vessel

103
Q

What is deep vein thrombosis caused by

A

. endothelial damage
. hypercoagulability - blood vessel chemistry can change = more likely for blood clot to form
. venous stasis - slow blood flow in vein usually of legs

104
Q

what are the symptoms of Deep vein thrombosis

A

. pain
. swelling
. redness
. warmness

105
Q

what is venous thromboembolism ?

A

it is a consequence of thrombosis where part of blood clot becomes detached and travels to the lungs
- Bit of clot breaks off and starts circulating in blood until it gets to lungs - that bit thrombosis will block vascular system of lungs

106
Q

what is embolism?

A

obstruction of an artery, typically by a clot of blood or an air bubble or plaque
Anything that circulates in vascular system which causes blockage of vessel

107
Q

Why MIGHT atheroma block vessel but probably not

A

Probably cause blood clot and/or embolism form - come from blood clot or piece of fat/tumour/plaque which circulates in system until it impacts on vessel blocking it

108
Q

What is an aneurysm

A

Weaken blood vessels wall = blood vessel wall bulges out

109
Q

What is saccular aneurysm

A

An aneurysm that resembles a small sack - on 1 point

110
Q

What is fusifrom aneurysm

A

Involves the entire circumference of the vessel

111
Q

What happens when aneurysms burst

A

Leads to haemorrhages in brain

112
Q

What is site of thrombosis

A

Aneurysms

113
Q

How can you fix aneurysms

A

They can be clipped or bound

114
Q

Summary of cardiovascular disease

A

atheroma is growth of plaques in the walls of artery this leads to
. aneurysm
. thrombosis - blood clot
. embolism
leading to blockage
leading to ischaemia - not enough oxygen in tissue
leading to infraction - tissue death due to lack of blood supply following blood vessel blockage
- end results = BLOOD VESSEL BLOCKED

115
Q

what does the size of infracts depend on ?

A

. extent of collateral circulation - how many alternative blood supplies are there to that structure
. duration of ischaemia - how long did O2 stay cut off
. susceptibility of tissue to ischaemia

116
Q

where do infracts occur ?

A

infracts can occur everywhere in the body
. spleen
. kidney
. liver

117
Q

what does the seriousness of an infract depend on?

A

The tissue

118
Q

What is ischaemia

A

Lack of oxygen

119
Q

what is the most susceptible tissue to infarcts ?

A

. CNS tissue - neurons in CNS
. CNS tissue need continuous supply of oxygen = lack of O2 is severe = sensitive to lack of O2
. CNS tissue does not regenerate = once neurons die, they stay dead = CNS irreversible

120
Q

What is stroke

A

Death of neurons in CNS due to lack of oxygen

Cardiovascular accident

121
Q

what are the two types of CNS strokes ?

A

. haemorrhagic - aneurysm bleed in brain = aneurysm = 20%

. ischaemic/occlusive - blood vessel gets blocked

122
Q

what is an example of organ that can have multiple infracts ?

A

kidneys
have a large functional reserve and extensive and multiple infracts are needed to impair function noticeably
You can almost wipe out 80% of kidney with infarcts before noticing

123
Q

What organs are sensitive to ischaemia

A

Heart

CNS

124
Q

Why is myocardial infarction serious

A
  1. the heart needs to keep beating uninterrupted

2. cardiac muscle is amitotic ( stays dead once killed )

125
Q

what is the function of the right and left coronary arteries ?

A

they supply the heart muscle itself with blood

they are susceptible to plaque formation

126
Q

what is coronary arterial disease / ischaemic heart disease ?

A

. the narrowing of the coronary arteries by atheroma results in the heart muscle receiving insufficient oxygen leading to impaired contraction due to atheromal plaque formation in one of coronary arteries = insufficient blood supply to heart muscle itself
- Atheroma in coronary arteries

127
Q

what is the consequence of atheroma in coronary arteries ?

A

. angina pectoris

. myocardial infraction ( heart attack )

128
Q

what is angina pectoris ?

A

caused by short term inadequacy of the blood supply to the heart during times of increased demand = indicates you have impaired coronary circulation
e.g. stress
During an attack there is no tissue death = no infarct
Atheroma plaque in coronary arteries = in times of increased demand not enough blood can get through coronary arteries = sharp attack of pain in chest through to arms

129
Q

what is myocardial infraction ( heart attack )

A

blood supply is disrupted for longer
e.g if thrombosis forms on an atheromatous plaque in the coronary arteries , heart muscle may die = heart receives lack of O2

130
Q

What is the lease severe consequence of atheroma in coronary arteries

A

Angina Pectoris

131
Q

what does the severity of infarcted myocardial tissue depend on ?

A

Area of blockage and which part of heart dies

Size and location

132
Q

what are causes of death following myocardial infarction ?

A
  1. insufficient cardiac output - not enough blood pushed if in left ventricles = bits of body starved of O2 = death
  2. rupture of infracted area some time after attack
  3. ventricular fibrillation - heart quivers instead of pumping due to disorganized electrical activity in the ventricles.
  4. pulmonary oedema- fluid accumulates in the air sacs of the lungs - If left ventricle not pushing out enough blood - all blood fill pulmonary vein in lungs to attempt to lower b.p,fluid in lungs
133
Q

how to prevent myocardial infraction ?

A
  1. clot bursting drugs
  2. drugs to prevent clots forming ( aspirin, heparin )
  3. coronary by-pass surgery
  4. angioplasty/stent
  5. injection of stem cells into infracted area to produce new cardiac muscle
134
Q

How do clot bursting drugs prevent myocardial infarction

A

Dissolve blood clots once its formed - have to recognize it quickly

135
Q

How does coronary by-pass surgery prevent myocardial infarction

A

By - pass blockage = blood vessels from patients own body - sew one end into aorta - major arteries and other end = bung blockage = bypass it and get blood into coronary circlulation

136
Q

How does angioplasty/stent prevent myocardial infarction

A

Insert catheter into blood vessels ( tube ) - goes up to where atheromatous plaque is and blow air into tube and inflate a baloon = squash plaque. Deflate baloon and pull out catheter = widens blood vessel or spring coiled around baloon so when you deflate it and pull it out, spring stays in place = stent

137
Q

How does injection of stem cells into infracted area prevent myocardial infarction

A

Pluripotent stem cells = develop into any tissue in body

stem cells from bone marrow - inject them into where infarct is = regenerate cardiac muscle

138
Q

what are examples of drugs to lower blood pressure and lessen risk of CVA ?

A
  1. aspirin - inhibits production of thromboxane - makes blood clots less likely to form - interferes with blood platelets
  2. ACE inhibitor - prevents vasoconstriction - wider vessels via renin pathway = stops conversion of Angiotensin I to Angiotensin II
  3. statins - lower cholesterol, plant derived drug
  4. arterial calcium channel blocker - prevents vasoconstriction - stops smooth muscle in vessel contracting - blood vessels dilate