Cardiovascular Flashcards
Fixed splitting
ASD (L to R shunt and increased flow thru pulmonic valve such that, regardless of breath, pulmonic closure is greatly delayed)
Wide splitting
Conditions that delay RV emptying (pulmonic stenosis, RBBB)
Paradoxical splitting
Conditions that delay LV emptying (AS, LBBB)
Mitral/tricuspid regurgitation
Holosystolic, high pitched “blowing murmur”
Aortic stenosis
Crescendo-descrescendo systolic ejection murmur following ejection click (abrupt halting of valve leaflets)
VSD
Holosystolic, harsh-sounding murmur
Mitral prolapse
Late systolic crescendo murmur with midsystolic click (sudden tensing of chordae tendinae)
Aortic regurgitation
Immediate high-pitched “blowing” diastolic murmur
Mitral stenosis
Delayed rumbling late diastolic murmur, follows opening snap (abrupt halt in leaflet motion)
Patent ductus arteriosus
Continuous machine-like murmur
Anything that prolongs the QT interval can predispose to…
torsades de pointes (Vtach)
Congenital heart disease (5)
Truncus arteriosus Transposition of great vessels Tricuspid atresia Tetralogy of Fallot Total anomalous pulmonary venous return (TAPVR)
L to R shunts
VSD > ASD > PDA
Tetralogy of Fallot parts
PROVe
- Pulmonary stenosis
- RVH
- Overriding aorta (overrides VSD)
- VSD
Transposition of great vessels due to…
failure of the aorticopulmonary septum to spiral
Transposition of great vessels associated with…
maternal diabetes
Infantile coarctation of aorta associated with…
Turner syndrome
Adult type coarctation of the aorta (postductal) associated with…(3)
notching of ribs, HTN in UE, weak pulses in LE
For PDA, close with #1, keep open with #2
#1 indomethacin #2 PGE
Causes of renal artery stenosis
Atherosclerosis (elderly male) Fibromuscular dysplasia (young female)
“Pipestem” arteries
Monckeberg pattern of arteriosclerosis (calcification in media of arteries)
AAA epidemiology
Male smokers > 50y/o
Thoracic aortic aneurysm appearance
“tree bark” appearance
Aortic aneurysm triad of sx
Hypotension
Pulsatile abdominal mass
Flank pain
Aortic dissection associated with…
HTN
Cystic medial necrosis (Marfan’s syndrome)
Most common cause of death from aortic dissection
pericardial tamponade
ST depression represents…
subendocardial ischemia
ST elevation represents…
transmural infarct
Tx for MI
ASA/heparin to limit thrombosis Supp O2 to minimize ischemia Nitrates to vasodilate, dec preload BB to slow HR, dec demand for O2 ACEI to dec LV dilation by volume, dec afterload
Evolution of MI
Coag necrosis – 1d – Acute inflammation – 1wk – granulation tissue – 1mo – scar
Dressler syndrome
autoimmune pericarditis 6-8wks after MI
Risk in early period after MI
arrhythmia
Risks at 5-10d post-MI
free wall rupture, tamponade, papillary muscle rupture, interventricular septal rupture
Risk at 7wks post-MI
Ventricular aneurysm
Complication 3-5d post-MI
Fibrinous pericarditis
Causes of dilated CM
ABCCCD Alcohol abuse wet Beriberi Coxsackie B virus myocarditis chronic Cocaine use Chagas' disease Doxorubicin toxicity hemochromatosis peripartum CM
Causes of restrictive CM
sarcoidosis amyloidosis postradiation fibrosis endocardial fibroelastosis Loffler's syndrome hemochromatosis
Main reasons for CHF symptoms
Decreased LV contractility leading to 1. Pulm venous congestion (pulm edema) 2. Dec cardiac output (activation of RAAS)
Bacterial endocarditis sx
Bacteria FROM JANE Fever Roth's spots Osler's nodes Murmur Janeway lesion Anemia of chronic dz Nail-bed hemorrhage Emboli (septic)
Tricuspid valve endocarditis due to…
IV drug abuse
S. aureus, Pseudomonas, Candida
Subacute bacterial endocarditis
viridans streptococci
sequela of dental procedures
Endocarditis with negative BCx
HACEK
Haemophilus, Actinobacillus, Cardiobacterium, Eikenella, Kingella
Bacterial endocarditis and colon cancer
S. bovis
Bacterial endocarditis and prosthetic valves
S. epidermidis
Nonbacterial endocarditis 2/2…
malignancy, hypercoagulable state, lupus (Libman Sacks)
Rheumatic fever sx
FEVERSS Fever Erythema marginatum Valvular damage ESR increased Red-hot joints (migratory polyarthritis) Subcutaneous nodules St. Vitus' dance (chorea)
Rheumatic fever consequence of….
pharyngeal infection with group A beta-hemolytic strep (Strep pyogenes)
Rheumatic fever affecting heart valves
Mitral > aortic»_space; tricuspid
Cardiac tamponade findings
hypoTN, increased JVD, distant heart sounds, increased HR, pulsus paradoxus
Most common primary cardiac tumor in adults
myxomas
Most common primary cardiac tumor in children
Rhabdomyomas
Raynaud’s disease
Decreased BF to skin 2/2 arteriolar vasospasm in response to cold temp or emotional stress
Raynaud’s phenomenon
2/2 mixed connective tissue disease, SLE, CREST syndrome
Large vessel vasculitis (2)
Temporal (giant cell) arteritis
Takayasu’s arteritis
Medium vessel vasculitis (3)
Polyarteritis nodosa
Kawasaki disease
Buerger’s disease (thromboangiitis obliterans)
Small vessel vasculitis (4)
Wegener granulomatosis
Microscopic polyangiitis
Churg-Strauss syndrome
Henoch Schonlein purpura
Most common form of vasculitis in older adults > 50y/o
Temporal (giant cell) arteritis
Temporal (giant cell) arteritis sx
U/l ha, jaw claudication
May progress to irreversible blindness (ophthalmic a. occlusion)
Takayasu’s arteritis affects…
Asian females <40y/o
String of pearls appearance on imaging
Polyarteritis nodosa (multiple aneurysms/constrictions on arteriogram, late complication)
Polyarteritis nodosa associated with…
Hep B seropositivity in 30% of patients
Kawasaki disease sx
CRASH & BURN (fever)
Conjunctivitis, Rash, Adenopathy, Strawberry tongue, Hands/feet erythema
Kawasaki disease affects…
Asian children < 4y/o
Buerger’s disease affects…
heavy smokers, males <40 y/o
How to remember Wegener granulomatosis
“C” distribution (nasopharynx, lungs, kidneys)
c-ANCA positive
tx with cyclophosphasmide, corticosteroids
Triad of Wegener granulomatosis
- Focal necrotizing vasculitis
- necrotizing granulomas in lung and upper airway
- necrotizing glomerulonephritis
Churg-Strauss syndrome
granulomatous vasculitis with EOSINOPHILIA (p-ANCA positive)
Most common form of childhood systemic vasculitis
Henoch-Schonlein purpura
Henoch-Schonlein purpura
Palpable purpura on buttocks/legs
Arthalgia
Abd pain
Hematuria (IgA nephropathy)
Sturge-Weber disease manifests as…
- port-wine stain on face
- i/l leptomeningeal angiomatosis (intracerebral AVM)
- seizures
4, early-onset glaucoma
PVC exposure
Angiosarcoma
Purple patches, plaques, nodules on skin
Kaposi’s sarcoma
1st line tx for HTN in pregnancy
hydralazine, methyldopa
Mechanism of antiarrhythmics
Slow or block conduction
Decrease slope of phase 0 depolarization
Increase threshold for firing in abnormal pacemaker cells
Class IA antiarrythmics
Quinidine
Procainamide
Disopyramide
“the Queen Proclaims Diso’s pyramid”
Class IB antiarrhythmics
Lidocaine Mexiletine Tocainide "I'd Buy Lidy's Mexican Tacos" "IB is Best post-MI"
Class IC antiarrhythmics
Flecainide
Propafenone
“IC is Contraindicated post-MI)
Causes increased toxicity for all class I drugs
Hyperkalemia
Class III antiarrhythmics (K channel blockers)
Ibutilide Sotalol Bretylium Amiodarone Dofetilide "K IS BAD"
Class IV antiarrhythmics (Ca channel blockers)
Verapamil
Diltiazem
Drug of choice in dx/abolishing SVT
Adenosine
Effective in torsades de pointes and digoxin toxicity
Mg2+