Cardiotropic Agents - Phosphodiesterase Inhibitors

Question 1

Cardiotropic Agents - Phosphodiesterase Inhibitors

Drug Names

Answer 1

Inamrinone (given when pt hasn’t responded to digoxin. diuretics, or vasodilators)

Milrinone* (short-term, given with digoxin and diuretics)

Question 2

Cardiotropic Agents - Phosphodiesterase Inhibitors

Actions

Answer 2

Blocks phosphodiesterase causing stronger contractions

Relaxes smooth muscle

Question 3

Cardiotropic Agents - Phosphodiesterase Inhibitors

Indications

Answer 3

Short-term HF in conjunction with or because of lack of response to digoxin or diuretics or vasodilators

Question 4

Cardiotropic Agents - Phosphodiesterase Inhibitors

Contraindications and cautions

Answer 4

CI: Allergy, Severe aortic or pulmonary disease, MI, Fluid volume deficit, Ventricular arrhythmia

Cautions: P & L, elderly

Question 5

Cardiotropic Agents - Phosphodiesterase Inhibitors

Adverse Effects

Answer 5

Arrhythmias
Hypotension
N/V
Thrombocytopenia
Pericarditis
Pleuritis
Fever
Chest pain
Burning @ inj site

Question 6

Cardiotropic Agents - Phosphodiesterase Inhibitors

DDI

Answer 6

Furosemide

Question 7

Cardiotropic Agents - Phosphodiesterase Inhibitors

Specific Nursing Considerations

Answer 7

Protect drug from light
Monitor pulse, BP, I&O, platelets before and during therapy
Crash cart nearby