Cardioresp differentials Flashcards
What is a key question to ask in a palpitations history and what are the red flags?
Presenting complaint: palpitations (1) essential to establish a timeline! - has the patient kept a record? NB: also if the patient is having palpitations in the consultation: ask them to tap it out on the table Red Flags: (2) chest pain? (3) collapse? (4) FHx of sudden cardiac death
What conditions should be considered as Ddx for palpitations?
1) ventricular tachycardia
2) Atrial fibrillation
3) Supraventricular tachycardia
4) ventricular ectopics
5) Anxiety
6) Thyrotoxicosis
7) Phaeochromacytoma
What are the S&Sx and HPC associated with ventricular tachycardia?
"Ventricular Tachy: • Dizziness/ sweating/ pain • Paroxysmal noct dyspnoea • Symptoms of acute HF/ shock/ chest pain/ syncope may be a medical emergency → A to E assessment and CPR (however, less likely as OSCE) • Broad QRS complex ECG"
What are the risk factors and Ddx associated with ventricular tachycardia?
• Recent MI • Any ischaemic changes to the heart • Normal cardiac RFs Ddx: • Any other palpitation
What investigations should be done if palpitations are suspected?
"• Bedside: full exam and hx, basic obs, ECG, BM • Labs: FBC, U+E, Lipid screen, Mg2+, Ca2+, TSH • Imaging: consider 24hr ECG, consider ECHO for structural changes "
What would the signs and symptoms/HPC of AF be?
"AF • Irregularly irregular • Consider type (first episode, paroxysmal, persistent, permanent) • Dizziness/ faintness • Consider in a HF pt"
What are the risk factors and DDx for AF?
"• Normal cardiac RF • Cardiac: HF, mitral stenosis, HTN • Infectious: pneumonia • Metabolic: hyperthyroidism • Stimulants: alcohol, caffeine" DDx= any other palpitation
What investigations should be done in palpitations?
“• Bedside: full exam and hx, basic obs, ECG, BM
• Labs: FBC, U+E, Lipid screen, Mg2+, Ca2+, TSH
• Imaging: consider 24hr ECG, consider ECHO for structural changes “
What are the S/Sx and HPC associated with supraventricular tachycardia?
“SVT
• Paroxysmal palpitations
• Possible syncope
• Dizziness/ sweating”
What are the risk factors for SVT?
what is the DDx?
“• Recent MI
• Any ischaemic changes to the heart
• Normal cardiac RF”
ddx: any other palpitation
What are the S/Sx associated with ventricular ectopics?
“Ventricular ectopics
• Pts feel a skipped beat then an uncomfortable lurch in their chest
• Associated sympathetic actvity (sweating, dizziness)
• Positional association: laying down
• On ECG the QRS complexes are wide”
What are the RF for ventricular ectopics?
What DDx are there for ventricular ectopics?
“• Recent MI
• Any ischaemic changes to the heart
• Normal cardiac RF”
Ddx: any other palpitation
What are the S/Sx and HPC of Anxiety?
“Anxiety
• Associated with a trigger
• Paroxysmal
• Tingling around lips, tingling in fingertips
• Make a big point of talking about social Hx for this one
• Associated nausea/ sweating/ dry mouth
What are the risk factors associated with anxiety?
What Ddx are there for anxiety?
RF:
• Make a point about SHx
DDx:
• Any of palpitations
• Anxiety precipitated by hyperthyroidism
[do HAD10 score]
What are S/Sx and HPC for thyrotoxicosis?
Thyrotoxicosis
• Classic thyroid symptoms
• ?Thyroid storm (delerium/ diarhhoea/ nausea/ vomiting with possible precipitating factors ie. recent illness/ stress/ trauma)
What are the RF and ddx for thyrotoxicosis?
RF: FHx
DDx: Anxiety [do anxiety screen e.g. HAD10 score] & AF
What are the S/Sx and HPC for phaeochromacytoma?
5 P’s
Pain, pallor, pressure (raised BP), pain (headache), perspiration
These Sx will occur in episodes and at the same time
What are the RF and DDx for phaeochromacytoma?
RF: Fhx
DDx: any of palpitations
What are the DDx for dyspnoea as a PC?
Dyspnoea Acute: • Asthma • Pneumonia • Acute pulmonary oedema • ACS • PE • Tension pneumothorax
Chronic • Lung malignancy • COPD (excluding IECOPD) • Pulmonary fibrosis • HF"
What are the red flags for a dyspnoea PC?
• Chest pain (MI) • Haemoptysis (PE/ lung ca) • Weightloss (lung ca/ COPD/ pulmonary fibrosis) • Heavy smoking history (lung ca/ COPD) • Asbestos (lung cancer> mesothelioma) • Unilateral leg swelling (PE)
What are the S/Sx & HPC for asthma?
"Asthma • Wheezing and breathlessness • Trigger (cold air/ exercise/ aspirin) • Night time worst • Consider background eczema/ allergy"
What are the RF and DDx for asthma?
RF: "• Atopic triad • Triggers • Care for aspirin induced" DDx: "• Acute pulmonary oedema • Foreign body obstruction"
What investigations should be done for a PC ?asthma in a Hx of dyspnoea?
- Bedside: full exam and Hx, peak flow, basic obs
- Labs: FBC, U+E, CRP, ESR, ABG
- Imaging: consider CXR (especially to rule out a foreign body obstruction)
- Special: spirometry, methacholine reversal test”
What are the S/Sx & HPC for pneumonia?
“Pneumonia
• Cough with green sputum (maybe haemoptysis)
• Fevers
• Pleuritc chest pain
• Possible background of COPD (H.Influenzae)
• It is essential to determine whether community/ hospital acquired”
e.g. have they been in hospital recently
What are the RF and Ddx for pneumonia
RF: "• Immunocompromised patients • HAP: care home/ hospital stay • ""Is anyone else around you experiencing similar symptoms)" DDx: "• Flu • Infective exac COPD (in smokers) • Asthma"
What investigations should be done for dyspnoea?
“• Bedside: full exam and Hx, peak flow, basic obs
• Labs: FBC, U+E, CRP, ESR, ABG, sputum culture, from results you would like to assess CURB65
• Imaging: CXR
• Special: spirometry, methacholine reversal test
What are the S/Sx of acute pulmonary oedema?
"Acute pulmonary oedema • Severe breathlesness • On background of ACS/ arrhythmia/ HF/ CRF • Orthopnoea and PND • ""Pink frothy sputum"" • ?silent MI in elderly pt"
What are the RF & Ddx for acute pulmonary oedema?
RF:
• Recent: HF/ MI/ ChronicRenalFailure/ liver failure
Ddx:
• Asthma
• COPD
• Pneumonia
What investigations should be done for ?acute pulmonary oedema in dyspnoea hx?
- A to E assessment but keeping the patient as up right as possible
- Investigate possible causes
What are the S/Sx & HPC for MI?
MI
• Central crushing chest pain >20mins
• Radiates
• N+V, sweating associated
Unstable angina
• Pain <5 minutes
• Relieved by GTN
What are the RF and Ddx for MI?
• Classic cardiac risk factors
ddx:
• The other ACSs that you don’t think it is
What investigations should be done for ?MI in dyspnoea hx?
- A to E assessment
- Bedside: ECG, BM, start ACS protocol
- Labs: FBC, U+E, troponin I (for SGUL), CK-MB, lipid profile
- Imaging: ECG
What are the S/Sx & HPC of a PE?
"PE • RF inc. Virchow's triad • Recent leg swelling • Cough and haemoptysis • Pleuritic chest pain • Associated weightloss ?undiagnosed malignancy"
What are the RF and DDx for PE?
RF: • Classic PE risk factors (think Virchow's triad) • Care for associated weightloss! • Remember to ask about pregnancy/ OCP • Remember to ask about kidney problems (important for management) DDx: • Acute pulmonary oedema • Tension pneumothorax
What investigations should be done for a ?PE in a dypnoea hx?
“• A to E assessment
• Risk stratify, Well’s score
• Depending on Well’s score/ pregnancy do D-dimer/ CTPA
• Bedside: ECG, ABG
• Labs: FBC, U+E, possible clotting screen, possible serum Ca2+/ LFTs for ?malignancy
• Imaging: CXR”
What are the S/Sx & HPC of tension pneumothorax?
Tension pneumothorax
• Pleuritic chest pain
• ?Marfan’s/ Ehlers Danlos
What are the RF and DDx for tension pneumothorax?
• Trauma!
• Other pneumothoraces: primary spontaneous (think marfan’s)/secondary spontaneous (tb, asthma, COPD)/ traumatic”
Ddx: PE, Asthma
What should the investigation for ?tension pneumothorax in a dypnoea hx be?
“• (If tension large bore needle into second intercostal space midclavicular line)
• A to E assessment
• Bedside: ECG, ABG
• Imaging: CXR (if suspected pneumothorax insert needle before CXR!)
What are the S/Sx & HPC of lung malignancy?
Lung malignancy
• Cough/ haemoptysis
• Chest pain
• Progressive decline
• Constitutional symptoms
• If you have time you can ask about mets (ie. bones ““any bone pain?””/ liver ““has your skin become more yellow””/ brain- ask about focal neurological defecits)
• If you have more time.. paraneoplastic syndromes (lambert eaton/ SIADH/ ectopic ACTH/ PTHrp)
What are the RF and DDx associated with lung malignancy?
RF: • Long smoking history • Asbestos exposure DDx: • COPD • Pulmonary fibrosis
What investigations should be done in a ?lung malignancy for dyspnoea hx?
- Bedside: Full exam and hx
- Labs: FBC, U+E, serum Ca2+, anaemia screen
- Imaging: CXR
• Depending on results of XR: if central lesion bronchoscopy for biopsy for histology and brushings for cytology, if peripheral lesion do biopsy for histology and FNA for cytology under CT guidance
What are the S/Sx & HPC of COPD?
"COPD • Cough/ wheeze/ sputum • Overlying pneumonia/ IECOPD? • Long smoking Hx • Weightloss"
What are the RF and ddx for COPD?
RF: • Long smoking history Ddx: • Asthma • Lung cancer
What Ix should be done for ?COPD in a dyspnoea Hx?
- Bedside: full exam and Hx, PEF, BMI
- Labs: FBC, U+E, serum Ca2+, anaemia screen
- Imaging: CXR
- Special: spirometry
What are the S/Sx and HPC for pulmonary fibrosis?
"Pulmonary fibrosis • SOBOE • Weightloss • Persistent dry cough • Might be idiopathic or associated with asbestos/ living or working on a farm/ other occupational hazards"
What are the RF and ddx for pulmonary fibrosis?
RF: • Occupational • Be prepared for pt to get worried at the mention of asbestos Ddx: "• Lung cancer • COPD"
What Ix should be done for ?pulm fibrosis in a dyspnoea hx?
- Bedside: full exam and Hx, ABG
- Labs: FBC, U+E,
- Imaging: CXR/ high resolution CT
What are the S/Sx & HPC for heart failure?
HF • SOBOE • PND/ orthopnoea • Cough with pink frothy sputum (sig: pulm oed) • Leg swelling • Consider determining whether RHF/ CHF
What are the RF and Ddx for HF?
RF: • Recent: MI • Underlying HTN • Valvular problems Ddx: • Acute pulmonary oedema
What investigations should be done in a ?heart failure in a SOB hx?
- Bedside: full exam and hx, ABG
- Labs: FBC, U+E, BNP
- Imaging: CXR/ TOE
What are the S/Sx & HPC of pleural effusion?
“Pleural effusion
• Pleuritic chest pain
• Exudative (inflam leaky capils): infection (pneumonia/tb)/ neoplasm/ inflammation (RA/ SLE)/ infarction
• Transudative (high pressure): CCF/ renal failure/ decreased albumin”
What are the RF and Ddx for pleural effusion?
RF:• Any underlying cause
ddx:• Pulmonary oedema
What Ix should be done for a ?pleural effusion in SOB Hx?
“• Full exam and Hx
• Labs: FBC, U+E, LFT, TFT, Ca ESR
• Imaging: CXR, US (for tapping)
• Diagnostic tap, send to: chemistry, bacteriology, cytology, immunology”
What are the red flags for chest pain?
- Sudden onset
- Duration >10/20 mins
- not relieved by GTN
- Associated dyspnoea
- PE RF
- Weight loss
- New onset dyspepsia and ALARMS (anaemia, loss of weight, malena, swallowing diff)
What are the differentials for chest pain?
- Stable angina
- unstable angina
- MI (and silent)
- Pneumonia
- PE
- Tension pneumothorax
- GORD
- MSK
- Aortic dissection
- Pericarditis
What are the S/Sx & HPC for stable angina?
"Stable angina • Lasts for 5 mins • Central chest pain that radiates • SOBOE • Relieved by: GTN, sometime antacids/ rest"
What are the RF and Ddx for stable angina?
RF: • Cardiac risk factors • Ask about cholesterol • Ask about diabetes • Ask about HTN" Ddx: • Other ACSs
What investigations should be done for ?stable angina in a chest pain hx?
“• Bedside: full exam and Hx, ECG, BM, basic obs (including BP)
• Labs: FBC, U+Es, lipid profile, trops to rule out
• Imaging: coronary angiography with Doppler
• Special: 24 hour ECG/ stress echo”
What are the S/Sx & HPC of unstable angina?
"Unstable angina • Lasts for 5 mins • Central chest pain that radiates • SOBOE • Background of stable angina • Not relieved by: GTN, sometime antacids/ rest"
what are the rf and ddx for unstable angina?
• Cardiac risk factors • Ask about cholesterol • Ask about diabetes • Ask about HTN ddx: • Other ACSs
What investigations should be done for ?unstable angina in a chest pain hx?
- Bedside: full exam and Hx, ECG, BM, basic obs (including BP)
- Labs: FBC, U+Es, lipid profile, trops to rule out
- Imaging: coronary angiography with Doppler
- Special: 24 hour ECG/ stress echo
What are the S/Sx & HPC of MI?
MI
• Central crushing chest pain >20mins
• Radiates
• N+V, sweating associated
Silent MI
• N+V, sweating associated
• Diabetics and elderly
What are the RF and Ddx in a ?MI chest pain hx?
RF: • Cardiac risk factors • Ask about cholesterol • Ask about diabetes • Ask about HTN" Ddx: • Other ACSs
What are the investigations in a ?MI chest pain hx?
- A to E assessment
- Bedside: ECG, BM, start ACS protocol
- Labs: FBC, U+E, troponin I (for SGUL), CK-MB, lipid profile
- Imaging: ECG
What are the S/Sx of pneumonia?
“Pneumonia
• Cough with green sputum (maybe haemoptysis)
• Fevers
• Pleuritc chest pain
• Possible background of COPD (H.Influenzae)
• It is essential to determine whether community/ hospital acquired”
What are the RF and ddx for pneumonia (chest pain hx?)
RF: • Immunocompromised patients • HAP: care home/ hospital stay • ""Is anyone else around you experiencing similar symptoms) Ddx: "• Flu • IECOPD (in smokers) • Asthma"
What are the investigations to be done in a ?pneumonia chest pain hx?
“• Bedside: full exam and Hx, peak flow, basic obs
• Labs: FBC, U+E, CRP, ESR, ABG, sputum culture, from results you would like to assess CURB65
• Imaging: CXR
• Special: spirometry, methacholine reversal test”
What are the S/Sx & HPC of PE?
"PE • RF inc. Virchow's triad • Recent leg swelling • Cough and haemoptysis • Pleuritic chest pain • Associated weightloss ?undiagnosed malignancy"
What are the RF and ddx associated with PE?
RF: • Classic PE risk factors (think Virchow's triad) • Care for associated weightloss! • Remember to ask about pregnancy/ OCP • Remember to ask about kidney problems (important for management)" "• Ddx: Acute pulmonary oedema • Tension pneumothorax"
What are the Ix for a ?PE in a chest pain history?
- A to E assessment
- Risk stratify, Well’s score
- Depending on Well’s score/ pregnancy do D-dimer/ CTPA
- Bedside: ECG, ABG
- Labs: FBC, U+E, possible clotting screen, possible serum Ca2+/ LFTs for ?malignancy
- Imaging: CXR”
What are the S/Sx of tension pneumothorax?
the RF?
the ddx?
treatment?
"Tension pneumothorax • Pleuritic chest pain • ?Marfan's/ Ehlers Danlos" RF: • Trauma! • Other pneumothoraces: primary spontaneous (think marfan's)/secondary spontaneous (tb, asthma, COPD)/ traumatic" DDx: • PE • Asthma Ix: "• (If tension large bore needle into second intercostal space midclavicular line) • A to E assessment • Bedside: ECG, ABG • Imaging: CXR (if suspected pneumothorax insert needle before CXR!)
What are the S/Sx of GORD?
“GORD
• Retrosternal/ pain on laying flat/ bending forward/ straining
• Relieved by swallowing/ antacids
• ALARM: Anorexia/ Loss of weight/ Anaemia/ Recent onset or progression/ Melaena (>55 with dyspepsia, ALARM and dyspepsia with dysphagia get 2wr)”
What are the RF and ddx for gord?
RF: • Increased abdominal pressure (weight/ prengancy) ddx: "• Gastritis • Oesophageal carcinoma"
What investigations should be done for GORD?
- Bedside: full exam and hx
- Labs: FBC, anaemia screen
- Imaging: OGD
What are the S/Sx of MSK on a chest pain hx?
RF?
DDx?
MSK • Pain on pressure • Trauma • Younger RF: • Trauma ddx: • Pleuracy • GORD
What are the S/Sx of aortic dissection?
"Aortic dissection • Tearing between shoulder blades • Recent trauma/ surgery • Background HTN/ bicuspid aortic valve/ Ehler's Danlos • Ischaemic limbs/ "
What are the RF and ddx for an aortic dissection?
RF • Recent trauma/ surgery • Background HTN/ bicuspid aortic " ddx: - ACS
What are the investigations that should be done in a ?aortic dissection chest pain hx?
“• A to E assessment
• Bedside: obs/ BM, full exam and hx, ECG
• Labs: FBC, U+E, cardiac enzymes
• Imaging: CT angiogram”
What are the S/Sx of pericarditis?
“Pericarditis
• Pleuritc chest pain felt retrosternally
• Aggravated by coughing
• Better leaning forward
• Dresslers: high grade fever/ malaise/ weakness
• Post fibrinous: low grade fever”
What are the Rf & ddx for pericarditis?
RF:
• Previous MI
Ddx:
• GORD
• ACS
What are the investigations for a ?pericarditis in a chest pain history?
“• Bedside: full exam and Hx, basic obs, ECG
• Labs: FBC, U+E, CRP, ESR