Cardiology Flashcards
What are the causes of aortic stenosis?
age related calcification (most common >65) bicuspid aortic valve (most common <65) rheumatic heart disease Williams syndrome (supravalvular AS) HOCM (subvalvular AS)
What does an AS murmur sound like and where is it heard?
ESM
right 2nd ICS
loudest on expiration
radiates to the carotids
what does the pulse feel like in AS?
slow rising, narrow pulse pressure (<30 mmHg)
what are the S/S of severe AS?
SAD
syncope
angina
dyspnoea
What are some differentials of AS?
aortic sclerosis
hOCM
MR
PS/TR
What signs would be picked up with severe AS?
Absent S2, S4
narrow PP
LVF (decompensation)
What investigations would you do for AS?
ECG (LCH, arrhythmia)
Bloods (FBC, U&E, BNP, lipids, glucose)
Blood culture
CXR (calcified valves, LVH, pul oedema)
Echo +/-doppler (assess severity, cause and LV function)
Coronary angiography - often done prior to surgery as cardiovascular disease may co-exist.
What would be seen on echo in severe AS?
Valve area <1cm^2
Pressure gradient >40 mmHg
Jet velocity >4m/s
What is the management of AS?
MDT - cardiologist, GP, SNP, cardiothoracic surgeon, dietician, OT/physio
RF modification
Regular f/u
Surgical:
- open replacement (biological or artificial valve)
- TAVI
- balloon valvuloplasty
- sutureless AV replacement
What are the types of artificial valve?
- Starr-Edwards (ball in cage)
2. Tilting disc/bileaflet
What do you hear in AR?
early diastolic murmur
loudest at left lower sternal edge 3rd ICS (Erbs point)
loudest sitting up on expiration
+/- mid diastolic murmur (austin flint of regurgitant jet causing MS)
What peripheral signs may be seen in AR?
AORTIC MAN
Beckers sign (retinal artery pulsation)
Mueller signs (systolic pulsations of uvula)
De Musset’s sign (nodding head)
Corrigan’s sign (carotid pulsation)
Quincke’s sign (pulsatile nail bed)
Traube’s sign (pistol-shot femoral pulses)
Duroziez’s sign (femoral artery compression)
What signs of AR may be identified in the pulse?
Corrigan's pulse (water hammer pulse) Wide PP (180/45)
What are the signs of severe AR?
Collapsing pulse
Wide PP
LVF
What are some causes of AR?
Acute:
Infective endocarditis
Aortic dissection (standard type A)
syphilis
Chronic: bicuspid aortic valve RHD autoimmune (anklyosing spondylitis, RhA, SLE) CTD (Ehler's danlos, Marfarns) HTN
What are the investigations for AR?
ECG (LVH, LV strain - lateral lead TWI)
Bloods (FBC, U&E, NT-proBNP, lipids, glucose, ESR, HLA-B27, ANA)
CXR (cardiomegaly, LVH, pulmonary oedema)
Echo +/- doppler
Coronary angiography
what would be seen on echo/doppler in severe AR?
Jet width >65% outflow tract
regurgitant jet volume
premature closing of mitral valve
what is the management of AR?
General:
MDT
RF modification
Regular F/U
Medical:
reduce after load -> ACEi, BB, diuretics
Surgical:
valve replacement before LV dilatation and dysfunction
what are indications for surgical management of AR?
NYHA >2 LV dysfunction: - pulse pressure >100 mmHg - ECG changes (TWI in lateral leads) - LV enlargement on CXR or EF <50%
What are the peripheral signs of MS?
Malar flush
what is the pulse like in MS?
Often irregular (AF) Can be normal
What signs can be found on the precordium in MS?
Apex: tapping (palpable S1), non displaced, left parasternal heave (RVH secondary to pul.HTN)
Sounds: loud S1, early diastolic opening snap +/- loud S2 if pul HTN
What does the murmur sound like in MS?
Mid diastolic murmur
loudest in left lateral at end expiration with bell
radiates to axilla
+/- Graham Steell murmur (EDM 2nd to PR)
What signs are seen in severe MS?
Malar flush, longer murmur, LVF
What are some causes of MS?
Rheumatic heart diseases
austin flint murmur
Rare: prosthetic valve, congenital
What are some differentials of MS?
AR
TS
PR
What are some signs of pulmonary hypertension?
malar flush
JVP with large V waves
right ventricular heave
loud s2 (p2)
What are some investigations for MS?
ECG (p mitrale, AF)
Bloods (FBC, U&E, NT-proBNP, lipids, glucose)
CXR (LA hypertrophy (splaying of carina), calcified mitral valve, pul oedema)
Echo +/- doppler
Coronary angiography
what would you see on echo/doppler in severe MS?
Valve orifice <1cm^2
Pressure gradient >10 mmHg
Pul. artery SBP >50 mmHg
What is the management of MS?
General:
MDT
RF modification
Regular F/U
Medical:
RhF prophylaxis (benzylpenicillin)
AF (Rate control + DOAC)
Diuretics (symptomatic relief)
Surgical:
1st: balloon valvuloplasty
valvotomy/commissurotomy (valve repair)
Valve replacement (if repair not poss)
What are the indications for surgery in MS?
Moderate severe MS (symptomatic or non-symptomatic)
When is balloon valvulplasty contraindicated?
left atrial appendage thrombus, calcified valve
what pulse signs can be seen in MR?
irregular/AF
what signs may be present on the precordium in MR?
Apex: displaced (ventricle pumps SV and regurgitant volume), parasternal heave (RVH)
Sounds: soft S1 +/- loud S2
What murmur is heard in mitral regurgitation?
pansystolic murmur
loudest in left lateral position at end expiration in apex
radiates to axilla
What are the signs of severe AF?
LVF, AF
What are some differentials of MR?
AS,
VSD,
TR
PS
What are some causes of MR?
Acute:
IE
IHD (MI) - papillary muscle rupture, chord tendinae rupture
Chronic: mitral valve prolapse (2% population - mid systolic murmur) RHD calcification CTD (marfan's, Ehlers danlos)
What signs are seen in papillary muscle rupture?
new systolic murmur (MR)
hypotension
pulmonary oedema
What are the investigations for MR?
ECG (P mitrale, AF, LVH)
Bloods (FBC, U&E, NT-proBNP, lipids, glucose
CXR (LA/LV hypertrophy, calcified mitral valve, pulmonary oedema)
Echo +/- doppler assessing severity, cusp calcification and LV function
coronary angiography
what is seen on echo in severe MR?
Jet width >0.6 cm
systolic pulmonary flow reversal
regurgitant volume >60 ml
What is the management of MR?
General: MDT
RF modification
regular FU
Medical: reduce afterload
AF (control rate + rhythm + anticoagulant)
Reduce after load (ACEI, BB (carvedilol), diuretics)
Surgical:
valve replacement
repair
What are the indications for surgery in MR?
Symptomatic
Prognosis of MR?
Asymptomatic ->10 years
Symptomatic - 25% mortality at 5 years
What are the immediate complications of MI?
- cardiac arrest
- cardiogenic shock
- tachyarrhythmia (vf, vt)
- bradyarrhythmia (av block)
What are the early complications of MI?
Pericarditis / Dresslers
Left ventricular free wall rupture
VSD and acute HF
What are the late complications of MI?
Chronic heart failure
Left ventricular aneurysm
What classification can be used for heart failure?
New York Heart Association Classification
What are the stages of the NYHA?
I - no limitation of acitivty
II - comfortable at rest, dyspnoea on ordinary activity
III - marked limitation of ordinary activity
IV - dyspnoea at rest
what is a normal ejection fraction?
45-60%
Which drugs are contraindicated in heart failure?
thiozoladinediones verapamil NSAIDs (fluid retention) Glucocorticoids (fluid retention) Flecainide
What is the the management of heart failure
BASHeD up heart (BB, ACEi, spiro, hydralazine, digoxin)
1st line: ACEi + BB (reduced EF-carvedilol) or loop diuretic (preserved EF)
2nd line: spironolactone
3rd line (specialist); hydralazine + nitrate
ivabridine (EF <35%), HR >75
valsartan
digoxin
cardiac resynchronisation +/- ICD
Other:
offer annual influenza
one of pneumococcal vaccine
What are the s/s of angina
CP is sharp
CP precipitated by physical exertion
CP relieved by GTN within 5mins
Stable = 3/3
atypical = 2/3
non anginal = <1/3
What are the investigations for stable angina?
- CTCA -> calcium score
- non invasive functional imaging:
- Stress echo
- Contrast enhanced perfusion MR
- MR for stress induced wall motion abnormalities
- MPS SPECT - coronary angiography
What does calcium score show?
Risk of MI/stroke at 10 years
percentiles(>75th = 15-20%)
What is the management of angina?
Conservative:
stop smoking
weight loss and exercise
healthy diet (fish, F+V, reduced sat fat)
Medical:
1st: GTN + BB or CCB (non-DHP e.g. verapamil/diltiazem)
2nd: GTN + BB + CCB (DHP)
3rd: long acting nitrate, ivabradine, nicorandil, ranolazine
Secondary prevention: aspirin 75 OD atojvastation ACEi (if angina and DM) antihypertensives
which CCBs should never be combined with beta blockers?
non-DHP CCBs:
verapamil
diltiazem
interacts with AV node conduction and may cause complete heart block
What are the contraindications to BB?
hypotension, bradycardia, asthma, HF
What are the contraindications to CCB?
hypotension, bradycardia, peripheral oedema
DHP>non-DHP for peripheral oedema
What are some causes of AF?
IHD rheumatic HD (MR, MS) Hyperthyroid infection PE cardiomyopathy alcohol bronchial cancer
what are the types of AF?
acute (<48H) Paroxysmal AF (<7d, recurs) persistent AF (>7d, may recur even after cardioversion)
When should you rhythm control rather than rate control?
reversible af
Coexistent heart failure caused by AF
New onset AF
When should those with AF be anti coagulated and what with?
AF<48h - LMWH
AF >48h- apixaban …
… for 3w before cardioversion
…for 4w after cardioversion or lifelong depending on CHASVASc
What are the rate control strategies for AF?
1st line: beta blocker or rate limiting CCB (verapamil>diltiazem)
2nd line: digoxin + CCB or BB; mono therapy in asthmatic with HF
3rd line: amiodarone