Carboxylic Acid Derivatives Flashcards
What has a higher boiling point ? Acyl halide vs carboxylic acids
Carboxylic acids
What is the most reactive carboxylic acid derivative
Acyl halides
Why is the acyl halide very reactive ?
The greater electron withdrawing power of the halogen makes the carbonyl carbon more susceptible to attack
Why do anhydrides have lower boiling points than carboxylic acids ?
No hydrogen bonding
When does an anhydride have a higher boiling point than a carboxylic acid ?
When the anhydride has a much larger molecular weight , this is more influential than hydrogen bonding
Condensation of two carboxylic acids to form an anhydride needs what conditions ?
Anhydrous conditions !! Water will make it go back. You need reagents like an anhydride or DCC and phosphorus pentachloride
Esters have ____ melting and boiling points than comparable carboxylic acids of the same size ?
Lower
Esters and water solubility ?
Small ones = good
Big ones = decreases
Esters of long chain carboxylic acids often called fatty acids and glycerol
Triacylglycerols
Saponification is the process whereby fats are processed under ____ conditions to produce soaps
Basic
Grignard reagent will produce ___ alcohols with two equivalents. The intermediate ketone can be isolated only if?
Tertiary
The alkyl groups are sufficiently bulky
Claisen reaction ? Under what conditions
Esters react under basic conditions and you get a betaketo ester
Phosphoric acid is ____ acidic than carboxylic acid
More
Structure of phospholipids ?
One phosphoric acid
Glycerol
Two carboxylic acids
Amides have ___ melting points and ___ water solubility
High
Good
