Capsules Flashcards
solid dosage form in which the drug is enclosed within either a hard or soft soluble container or “shell”
Capsules
give off water, which may cause softening of the capsule shells
Efflorescent materials
absorbs water, and may dehydrate the capsule shells
Deliquescent materials
Hard Gelatin Capsules – also called
Telescoping Capsules or Dry Filled Capsules
Type A HGC
pork skins by acid hydrolysis
Type B HGC
bone and animal skin by alkaline hydrolysis
contributes to the plasticity and clarity to the blend, thereby reducing haze or cloudiness of the tablet finished capsules
Pork Skin Gelatin
gives tough, firm film; but tends to be hazy and brittle by itself
Calf Bone Gelatin
Pin Method MECHANISMS
dipping, spinning, drying, stripping, and joining
This machine cannot fill pellets or granular materials
Zanasi
Finishing Filled Hard Gelatin Capsules
- Salt Polishing
- Pan polishing
- Cloth dusting
- Brushing
A convenient method for purpose of product identification and control.
Imprinting
also referred to as “Pearls”
Soft Gelatin Capsules
Method of Production of SOFT Gelatin Capsules
A. PLATE PROCESS
B. ROTARY DIE PROCESS
C. RECIPROCATING DIE PROCESS
state in which any residue of the tablet or capsule (except fragments of insoluble tablet coating) remains on the screen, resulting to a soft mass with no palpably visible core
Disintegration