Capsule

Question 1

diluents 고를때 consider

Answer 1

1. dose of drug
2. particle size/shape
3. solubility
4. stickiness
5. powder flow

Question 1

Fills for hard gelatin capsules (5)

Answer 1

1. powder
2. granules
   - improve mixing of drug/excipients
   - reduce segregation
3. pellets
   - different drug
   - multiple release profiles (MR)
4. mini tablet
   - different drugs
   - different release profile
5. liquids
   - must be non-aqueous
   - can be solid/liquid in rtp
   - for drugs with very low aqueous solubility

Question 2

diluents example

Answer 2

1. lactose
2. starch
3. CaPO4
4. Mannitol

Question 3

Glidants lubricants example

Answer 3

1. Fumed (colloidal) silicon dioxide
2. magnesium sterate

Question 4

disintegrant example

Answer 4

sodium starch glycollate

Question 5

wetting agent example

Answer 5

sodium lauryl sulphate

Question 6

extended release- monolithic - dual capsule system

Answer 6

: inserting smaller pre-filled capsule into larger liquid-filled capsule

advantage
- combination product
- dual release

Question 7

extended release- monolithic- enteric capsule

Answer 7

: inserting enteric polymer into capsule shell

advantage
- combination product
- sensitive drug = degradation in pH / temp during coating process

Question 8

how to increase patient centricity
- what’s safety issues

Answer 8

• poor adherence
• medication errors
• inappropriate medication alteration
• medication management issues

patient centric
- develop medicine that can be used intuitively w/o much guidance
- graphics
- colours
- sprinkle capsules & easy open capsules

Question 9

types of capsule filling machine

Answer 9

1. dependent (dosing system)
   - capsule body is used directly measure the amount of powder inserted
2. indepedent (dosing system)
   - powder flowability is used to predict capsule filling amount