Capillary Filtration And Lymph Flow

Question 1

What do caps allow for

Answer 1

Exchange of cargo between blood and tissues such as nutrients, oxygen, electrolytes, wastes, CO2 out

Small stuff, fluid portion of blood

Question 2

What does the endothelial allow for in caps

Answer 2

Diffusion of small solutes and water, usually no proiteins or cells because they are too big

Question 3

What does filtered fluid become

Answer 3

The interstitial fluid (intercellular)

Question 4

How do non-permeable things get across endothelium

Answer 4

Cross between the pore, PARACELLULAR

Question 5

How do larger things get across the endothelium

Answer 5

Diffuse across the endothelial cells if permeable- TRANSCELLULAR

Question 6

Where are there small pore sizes in the endothelium

Answer 6

Brain and eye

Question 7

Where are there large pore sizes in the endothelium

Answer 7

Kidney and liver

Question 8

What determines how selective the endothelium is?

Answer 8

Pore size

Question 9

Thickness of the walls of lymphatic

Answer 9

Thin walled

Question 10

Where are lymphatic found

Answer 10

Tissue surrounding cap beds

Question 11

What serves as drains for interstitial fluid

Answer 11

Lymphatics

Question 12

Where does lymph drain back into

Answer 12

Subclavian vein

Question 13

What are the drain pipes for the interstitial fluid

Answer 13

Lymphatic

Question 14

Process by which blood plasma is filtered across the capillary membrane to make the interstitial fluid

Answer 14

Ultrafiltration

Same process for making CSF, aqueous humor, urine, just modified

Question 15

What does ultrafiltration depend on

Answer 15

4 factors and permeability of endothelium are responsible for formation

Question 16

What are the 4 factors that determine ultrafiltration

Answer 16

• Capillary pressure (BP inside caps) Pc
• Plasma colloid osmotic pressure (albumin inside caps) Pi(c)
• interstitial fluid pressure (essentially 0) P(tis)
• interstitial fluid colloid osmotic pressure (usually 0) pi (tis)

Question 17

Filtration coefficient, similar to diffusion coefficient. How permeable the caps are

Answer 17

Filtration =Kf*net filtration pressure

Question 18

What determines how much fluid moves

Answer 18

Net filtration pressure

Question 19

Pc

Answer 19

Hydrostatic pressure inside the capillaries

Question 20

P(tis)

Answer 20

Hydrostatic pressure inside the tissue

Question 21

PI(c)

Answer 21

Osmotic pressure inside the caps

Question 22

PI(tis)

Answer 22

Osmotic pressure inside the tissue

Question 23

What pressures favor filtration

Answer 23

Capillary pressure (Pc) and interstitial fluid colloid osmotic pressure

Fluid leaving the cell

Question 24

What pressure favor reabsorption

Answer 24

Plasma colloid osmotic pressure and interstitial fluid pressure

Fluid coming in

Question 25

Increasing which of the following would increase interstitial fluid formation (cap filtration)

Answer 25

Capillary hydrostatic pressure Pressure in vessel pulling fluid towards it

Question 26

Administration of an alpha 1 receptor antagonist (blocker) would _______ filtration by increasing __________

Answer 26

Increase; capillary hydrostatic pressure

Question 27

How do you increase hydrostatic pressure

Answer 27

Block lymphatics, build up of fluid

Question 28

If hydrostatic pressure and on otic pressures in the body is the same, why does the liver produce more interstitial fluid than the brain

Answer 28

Liver capillaries have an increased Kf (bigger holes)

Question 29

Increase filtration

Answer 29

Increase interstitial fluid formation

Question 30

Increasing Pc (Capillary pressure) does what to filtration

Answer 30

Increases it Dilate arterioles, constrict venules, increase CVP

Question 31

What does increasing tissue osmotic pressure do to filtration

Answer 31

Increases it Block lymphatics, increase permeability to proteins

Question 32

What does decrease in capillary osmotic pressure do to filtration

Answer 32

Increases it Liver failure, starvation

Question 33

What does decreasing tissue pressure do to filtration

Answer 33

Increases it Increase lymph drainage (not really possible)

Question 34

What does increasing Kf do to filtration

Answer 34

Increases it Burns, inflammation Increases permeability

Question 35

Changes in _________ resistance affects filtration more than _______

Answer 35

Venous | Arteriolar

Question 36

What side is mroe important in cap flow

Answer 36

Venous

Question 37

What does a decrease in capillary pressure do to filtration

Answer 37

Decreases it Constrict arterioles, dilate venules, decrease CVP, hemorrhage

Question 38

Decrease filtration

Answer 38

Reduce interstitial fluid formation

Question 39

What happens to filtration when you decrease tissue osmotic pressure

Answer 39

Decreases it. More lymph drainage Rid of protein that got out

Question 40

What happens when tou increase osmotic cap pressure to filtration

Answer 40

Decreases filtration Dehydration, some cancers, hemolytic anemia

Question 41

What happens to filtration when you increase pressure of tissue

Answer 41

Decreases it Edema, physical compression of tissue

Question 42

What happens to filtration when you decrease Kf?

Answer 42

Decreases filtration Thickening of vessel walls, fibrosis

Question 43

All solutes move across the cap by ______

Answer 43

Diffusion | Cap pores slow large solutes

Question 44

What is diffusion of small or soluble molecules limited by

Answer 44

Blood flow

Question 45

What is flow (perfusion) limited

Answer 45

Diffusion of small or soluble things Equibrialtes qucikly

Question 46

Large or insoluble molecule are limited by

Answer 46

Pore size

Question 47

What is diffusion limited

Answer 47

Large or insoluble model veils Equibrilates slowly or not at all Distance to cell matters

Question 48

To increase tissue concentration of flow limited molecules, you must increase what

Answer 48

Bloodflow

Question 49

To increase concentration of diffusion limited molecules you must increase

Answer 49

Diffusion rate

Question 50

A patient has a chronic pulmonary artery hypertension, reduces cardiac hypertension, and peripheral edema. Which of the following is the most direct cause of the edema

Answer 50

Increased venous cap pressure (favors filtration)

Question 51

What is the difference between left and right heart failure

Answer 51

Left heart failure - lungs get fluid Right hear failure -fluid in periphery