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Physiology Block 6 > Capillary Filtration And Lymph Flow > Flashcards

Capillary Filtration And Lymph Flow Flashcards

1
Q

What do caps allow for

A

Exchange of cargo between blood and tissues such as nutrients, oxygen, electrolytes, wastes, CO2 out

Small stuff, fluid portion of blood

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2
Q

What does the endothelial allow for in caps

A

Diffusion of small solutes and water, usually no proiteins or cells because they are too big

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3
Q

What does filtered fluid become

A

The interstitial fluid (intercellular)

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4
Q

How do non-permeable things get across endothelium

A

Cross between the pore, PARACELLULAR

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5
Q

How do larger things get across the endothelium

A

Diffuse across the endothelial cells if permeable- TRANSCELLULAR

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6
Q

Where are there small pore sizes in the endothelium

A

Brain and eye

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7
Q

Where are there large pore sizes in the endothelium

A

Kidney and liver

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8
Q

What determines how selective the endothelium is?

A

Pore size

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9
Q

Thickness of the walls of lymphatic

A

Thin walled

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10
Q

Where are lymphatic found

A

Tissue surrounding cap beds

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11
Q

What serves as drains for interstitial fluid

A

Lymphatics

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12
Q

Where does lymph drain back into

A

Subclavian vein

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13
Q

What are the drain pipes for the interstitial fluid

A

Lymphatic

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14
Q

Process by which blood plasma is filtered across the capillary membrane to make the interstitial fluid

A

Ultrafiltration

Same process for making CSF, aqueous humor, urine, just modified

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15
Q

What does ultrafiltration depend on

A

4 factors and permeability of endothelium are responsible for formation

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16
Q

What are the 4 factors that determine ultrafiltration

A
  • Capillary pressure (BP inside caps) Pc
  • Plasma colloid osmotic pressure (albumin inside caps) Pi(c)
  • interstitial fluid pressure (essentially 0) P(tis)
  • interstitial fluid colloid osmotic pressure (usually 0) pi (tis)
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17
Q

Filtration coefficient, similar to diffusion coefficient. How permeable the caps are

A

Filtration =Kf*net filtration pressure

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18
Q

What determines how much fluid moves

A

Net filtration pressure

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19
Q

Pc

A

Hydrostatic pressure inside the capillaries

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20
Q

P(tis)

A

Hydrostatic pressure inside the tissue

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21
Q

PI(c)

A

Osmotic pressure inside the caps

22
Q

PI(tis)

A

Osmotic pressure inside the tissue

23
Q

What pressures favor filtration

A

Capillary pressure (Pc) and interstitial fluid colloid osmotic pressure

Fluid leaving the cell

24
Q

What pressure favor reabsorption

A

Plasma colloid osmotic pressure and interstitial fluid pressure

Fluid coming in

25
Q

Increasing which of the following would increase interstitial fluid formation (cap filtration)

A

Capillary hydrostatic pressure

Pressure in vessel pulling fluid towards it

26
Q

Administration of an alpha 1 receptor antagonist (blocker) would _______ filtration by increasing __________

A

Increase; capillary hydrostatic pressure

27
Q

How do you increase hydrostatic pressure

A

Block lymphatics, build up of fluid

28
Q

If hydrostatic pressure and on otic pressures in the body is the same, why does the liver produce more interstitial fluid than the brain

A

Liver capillaries have an increased Kf (bigger holes)

29
Q

Increase filtration

A

Increase interstitial fluid formation

30
Q

Increasing Pc (Capillary pressure) does what to filtration

A

Increases it

Dilate arterioles, constrict venules, increase CVP

31
Q

What does increasing tissue osmotic pressure do to filtration

A

Increases it

Block lymphatics, increase permeability to proteins

32
Q

What does decrease in capillary osmotic pressure do to filtration

A

Increases it

Liver failure, starvation

33
Q

What does decreasing tissue pressure do to filtration

A

Increases it

Increase lymph drainage (not really possible)

34
Q

What does increasing Kf do to filtration

A

Increases it

Burns, inflammation
Increases permeability

35
Q

Changes in _________ resistance affects filtration more than _______

A

Venous

Arteriolar

36
Q

What side is mroe important in cap flow

A

Venous

37
Q

What does a decrease in capillary pressure do to filtration

A

Decreases it

Constrict arterioles, dilate venules, decrease CVP, hemorrhage

38
Q

Decrease filtration

A

Reduce interstitial fluid formation

39
Q

What happens to filtration when you decrease tissue osmotic pressure

A

Decreases it.

More lymph drainage
Rid of protein that got out

40
Q

What happens when tou increase osmotic cap pressure to filtration

A

Decreases filtration

Dehydration, some cancers, hemolytic anemia

41
Q

What happens to filtration when you increase pressure of tissue

A

Decreases it

Edema, physical compression of tissue

42
Q

What happens to filtration when you decrease Kf?

A

Decreases filtration

Thickening of vessel walls, fibrosis

43
Q

All solutes move across the cap by ______

A

Diffusion

Cap pores slow large solutes

44
Q

What is diffusion of small or soluble molecules limited by

A

Blood flow

45
Q

What is flow (perfusion) limited

A

Diffusion of small or soluble things

Equibrialtes qucikly

46
Q

Large or insoluble molecule are limited by

A

Pore size

47
Q

What is diffusion limited

A

Large or insoluble model veils

Equibrilates slowly or not at all
Distance to cell matters

48
Q

To increase tissue concentration of flow limited molecules, you must increase what

A

Bloodflow

49
Q

To increase concentration of diffusion limited molecules you must increase

A

Diffusion rate

50
Q

A patient has a chronic pulmonary artery hypertension, reduces cardiac hypertension, and peripheral edema. Which of the following is the most direct cause of the edema

A

Increased venous cap pressure (favors filtration)

51
Q

What is the difference between left and right heart failure

A

Left heart failure
- lungs get fluid

Right hear failure
-fluid in periphery

Physiology Block 6 (7 decks)

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