Cannabinoids

Question 1

What is medical cannabis?

Answer 1

-several drugs
-over 100 known cannabinoids

Question 2

Stimuli for endocannabinoids

Answer 2

-stress: reduced axiety
-time of day

Question 3

THC vs CBD

Answer 3

THC- CB1 agonist: causes the muchies
CBD:

Question 4

CBD metabolism

Answer 4

-extensively metabolized
-3A4
-2C19!!! makes active metabolite 7-OH CBD

Question 5

What is the only active metabolite of CBD?

Answer 5

7-OH CBD

Question 6

Elimination of CBD

Answer 6

-long elimination half lives
-very lipophilic
-gets stored in fatty tissues

Question 7

Oral absorption of CBD

Answer 7

-very low oral absorption
-give with fatty meal to increase absorption(even milk)

Question 8

THC Metabolism

Answer 8

-active metabolite is quickly glucuronidated
-11-OH-THC

Question 9

Approved Uses for CBD

Answer 9

-Dravet Syndrome
-Lennox-Gastaut Syndrome
-Tuberous Sclerosis Complex

Question 10

Treatment options for Dravet syndrome

Answer 10

-First line: Valproic acid
2) +Clobazam
3) +STP or topiramate

Question 11

Treatment Options for Lennox-Gastaut (LGS)

Answer 11

1) VPA, LEV, or lamotrigine
2) +topiramate or clobazam
3) Rufinamide, lacosamide, zonisamide, or perapanel

Question 12

CBD drug-drug interactions

Question 13

side effects of CBD

Answer 13

-no changes in appetite
-diarrhea(drug suspended in oil or CB2 receptor)
-liver toxic
-sleepiness

Question 14

In what population, does CBD cause sedation?

Answer 14

-in patients taking clobazam because of CBD effects on CYP2C19

Question 15

Does CBD have abuse potential?

Answer 15

No
-no psychoactive potential

Question 16

What happens when you used CBD and THC together?

Answer 16

-psychoactive effect goes up
-cognition and memory are also affect
-heart rate increased