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Cancer > Cancer Qs > Flashcards

Cancer Qs Flashcards

1
Q

Which is the most common cause of cancer in females

Bowel
Prostate
Lung
Breast
Melanoma

A

Which is the most common cause of cancer in females

Bowel
Prostate
Lung
Breast
Melanoma

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2
Q

Which is the most common cause of cancer in men

Bowel
Prostate
Lung
Breast
Melanoma

A

Which is the most common cause of cancer in men

Bowel
Prostate
Lung
Breast
Melanoma

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3
Q

What is the single largest preventable cause of cancer within the UK? [1]

A

Smoking

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4
Q

Which of the following is not screened for cancer in the UK?

Retinoblastoma:
Bowel-FiT
Cervical
Ovarian
Breast

A

Which of the following is not screened for cancer in the UK?

Retinoblastoma:
Bowel-FiT
Cervical
Ovarian
Breast

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5
Q

Which of the following types of cancer is traditionally detected late on?

Thyroid
Oesophageal
Bladder
Ovarian
Breast

A

Which of the following types of cancer is traditionally detected late on?

Thyroid
Oesophageal
Bladder
Ovarian
Breast

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6
Q

Which of the following causes the upregulation of RAD51

Rb
BRCA1
WT1
BRCA2
p53

A

Which of the following causes the upregulation of RAD51

Rb
BRCA1
WT1
BRCA2
p53

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7
Q

p21 works at which cell cycle checkpoint? [1]

A

G1 to S phase

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8
Q

Name the gene that cause this function depicted
APC

TERT

P21

P53

BRCA1

A

Name the gene that cause this function depicted

APC

TERT: telomerase RT

P21

P53

BRCA1

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9
Q

BRCA1 / 2 is commonly associated with breast and which other type of cancer:

colorectal
rectal
ovarian
kidney
melonoma

A

BRCA1 / 2 is commonly associated with breast and which other type of cancer:

colorectal
rectal
ovarian
kidney
melonoma

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10
Q

An increase in mole greater than which size would suggest a melonoma?

Larger than 1/2 inch
Larger than 1/4 inch
Larger than 1/3 inch
Larger than 1/5 inch
Larger than 1/6 inch

A

An increase in mole greater than which size would suggest a melonoma?

Larger than 1/2 inch
Larger than 1/4 inch
Larger than 1/3 inch
Larger than 1/5 inch
Larger than 1/6 inch

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11
Q

But the following in order of cancer development:

Initiation; Hyperplasia; Dysplasia; In situ cancer; Metastasis; Invasive Cancer
Initiation; Dysplasia; Hyperplasia; In situ cancer; Metastasis; Invasive Cancer
Initiation; Dysplasia; Hyperplasia; In situ cancer; Invasive Cancer; Metastasis
Initiation; Hyperplasia; Dysplasia; Invasive Cancer; In situ cancer; Metastasis;
Initiation; Dysplasia; Hyperplasia; Invasive Cancer; In situ cancer; Metastasis

A

But the following in order of cancer development:

Initiation; Hyperplasia; Dysplasia; In situ cancer; Metastasis; Invasive Cancer
Initiation; Dysplasia; Hyperplasia; In situ cancer; Metastasis; Invasive Cancer
Initiation; Dysplasia; Hyperplasia; In situ cancer; Invasive Cancer; Metastasis
Initiation; Hyperplasia; Dysplasia; Invasive Cancer; In situ cancer; Metastasis
Initiation; Dysplasia; Hyperplasia; Invasive Cancer; In situ cancer; Metastasis

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12
Q

Which of the following is often indicative of early neoplastic process

Hyperplasia
Dysplasia
In situ cancer
Invasive cancer

A

Which of the following is often indicative of early neoplastic process

Hyperplasia
Dysplasia
In situ cancer
Invasive cancer

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13
Q

The location of prostate cancer metastasis is typically:

Breast
Liver
Kidney
Rectum
Bone

A

The location of prostate cancer metastasis is typically:

Breast
Liver
Kidney
Rectum
Bone

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14
Q
A
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15
Q
  1. What TNM classification below best describes this finding: very large tumor with 1 regional lymph node involvement, and spread to two regional organs?

A. T1N1M2
B. T4N1M1
C. T1N1M1
D. T4N1M2

A
  1. What TNM classification below best describes this finding: very large tumor with 1 regional lymph node involvement, and spread to two regional organs?

A. T1N1M2
B. T4N1M1
C. T1N1M1
D. T4N1M2

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16
Q
  1. The category “T” in the TNM system stands for:(Required)
    A. Time
    B. Tumor (primary)
    C. Tissue (primary)
    D. Tumor (secondary)
A
  1. The category “T” in the TNM system stands for:(Required)
    A. Time
    B. Tumor (primary)
    C. Tissue (primary)
    D. Tumor (secondary)
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17
Q

Colon cancer commonly metastasises to the

Brain
Bone
Kidney
Liver
Prostate

A

Colon cancer commonly metastasises to the

Brain
Bone
Kidney
Liver
Prostate

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18
Q

‘high immune cell density in the outer invasive margin and low density in the core’ describes which of the following

Immune-desert tumour
Inflamed tumour
Immune-included tumour
Immnune-excluded tumour

A

‘high immune cell density in the outer invasive margin and low density in the core’ describes which of the following

Immune-desert tumour
Inflamed tumour
Immune-included tumour
Immnune-excluded tumour

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19
Q

‘There is a tumour, but no T Cell army is present to mount an attack’ describes which of the following

Immune-desert tumour
Inflamed tumour
Immune-included tumour
Immnune-excluded tumour

A

‘There is a tumour, but no T Cell army is present to mount an attack’ describes which of the following

Immune-desert tumour
Inflamed tumour
Immune-included tumour
Immnune-excluded tumour

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20
Q

Atezolizumab binds to which of the following

PDL1
PDL2
CTLA4
PD1

A

Atezolizumab binds to which of the following

PDL1
PDL2
CTLA4
PD1

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21
Q

Pembrolizumab binds to which of the following

PDL1
PDL2
CTLA4
PD1

A

Pembrolizumab binds to which of the following

PDL1
PDL2
CTLA4
PD1

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22
Q

Ipilimubab binds to which of the following

PDL1
PDL2
CTLA4
PD1

A

Ipilimubab binds to which of the following

PDL1
PDL2
CTLA4
PD1

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23
Q

Tremelimubab binds to which of the following

PDL1
PDL2
CTLA4
PD1

A

Tremelimubab binds to which of the following

PDL1
PDL2
CTLA4
PD1

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24
Q

State 4 red flags for colorectal cancer [4]

A

Unexplained weight loss
Unexplained rectal bleeding
Over 60 & IDA
Over 60 & changes in bowel habit

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25
Q

State 5 red flags for ovarian cancer [5]

A

Persistent abdomial distension
Feeling full
Loss of appetite
Pelvic or abdominal pain
Increased frequency of urination

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26
Q

State a red flag for oeseophogeal cancer [1]

A

Dysphasia

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27
Q

c-fos causes what type of gain of function mutation?

  • Point mutation of non-coding region: promotor/enhancer region
  • Point mutation of coding region
  • Gene amplification
  • Translocation / transposition

Which type of cancer is this seen in?

A

Non-coding region (promotor/enhancer region).
E.g. c-Fos (transcription factor)

Seen in melanomas

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28
Q

Bcl2 causes what type of gain of function mutation?

  • Point mutation of non-coding region: promotor/enhancer region
  • Point mutation of coding region
  • Gene amplification
  • Translocation / transposition

Which type of cancer is this seen in?

A

Translocation / transposition: induction blocks apoptosis (anti-apoptotic gene).
Overexpression by (t14:18) (q32; 21).

Leads to follicular lymphoma

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29
Q

c-H-ras causes what type of gain of function mutation?

  • Point mutation of non-coding region: promotor/enhancer region
  • Point mutation of coding region
  • Gene amplification
  • Translocation / transposition

Which type of cancer is this seen in?

A

Coding region point mutation: leads to bladder cancer [1]

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30
Q

State the point mutation that occurs in c-H-ras mutation [1]

A

E.g. c-H-ras: (Gly) GGC – (Val) CTG.

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31
Q

K-ras is an oncogene that belongs to

Growth factor receptors
Signal transduction proteins
Transcription factors
Anti-antopic proteins

A

K-ras is an oncogene that belongs to

Growth factor receptors
Signal transduction proteins
Transcription factors
Anti-antopic proteins

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32
Q

C-myc is an oncogene that belongs to

Growth factor receptors
Signal transduction proteins
Transcription factors
Anti-antopic proteins

A

C-myc is an oncogene that belongs to

Growth factor receptors
Signal transduction proteins
Transcription factors
Anti-antopic proteins

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33
Q

B-Raf is an oncogene that belongs to

Growth factor receptors
Signal transduction proteins
Transcription factors
Anti-antopic proteins

A

B-Raf is an oncogene that belongs to

Growth factor receptors
Signal transduction proteins
Transcription factors
Anti-antopic proteins

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34
Q

Tumour Suppressor Genes: Loss of Function

Name two regions in which point mutations can occur:

Within the control element [1]

Within the gene [1]

A

Within the control element: Bax

Within the gene: P53

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35
Q

Which of the following is a pro-apoptopic tumour suppressor gene?

BRCA
Bcl2
Bax
pRB
p53

A

Which of the following is a pro-apoptopic tumour suppressor gene?

Bax

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36
Q

Which of the following is a caretaker tumour suppressor gene?

BRCA
Bcl2
Bax
pRB
p53

A

Which of the following is a caretake tumour suppressor gene?

BRCA

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37
Q

Which of the following are gatekeeper tumour suppressor genes? [2]

BRCA
Bcl2
Bax
pRB
p53

A

p53 & pRb

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38
Q

The list below all fall under which category

Growth factors (signalling proteins); Receptors (e.g. tyrosine kinase receptors; Intracellular signalling proteins e.g. kinases; Transcription factors; Anti-apoptotic proteins

Oncogene
Gatekeepers
Caretakes
Proto-oncogenes

A

The list below all fall under which category

Growth factors (signalling proteins); Receptors (e.g. tyrosine kinase receptors; Intracellular signalling proteins e.g. kinases; Transcription factors; Anti-apoptotic proteins

Oncogene
Gatekeepers
Caretakes
Proto-oncogenes

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39
Q

HER2 Receptor is what type of receptor?

GPCR
Enzyme-linked
Nucleus binding
Tyrosine-kinase

A

HER2 Receptor is what type of receptor?

GPCR
Enzyme-linked
Nucleus binding
Tyrosine-kinase

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40
Q

Which of the following is not a category of a proto-oncogene?

Growth factor
Growth factor receptor
Tyrosine kinase activation
Anti-apoptopic gene
Pro-apoptopic gene

A

Which of the following is not a category of a proto-oncogene?

Pro-apoptopic gene

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41
Q

Which of the following is not part of the role of gatekeeper ?

  • Apoptosis - related genes
  • Directly supresses growth/restricts proliferation
  • Cell cycle/cell division regulator genes
  • Maintains genetic stability: DNA repair proteins
  • Check point control genes
A

Which of the following is not part of the role of gatekeeper ?

  • Apoptosis - related genes
  • Directly supresses growth/restricts proliferation
  • Cell cycle/cell division regulator genes
  • Maintains genetic stability: DNA repair proteins - caretaker
  • Check point control genes
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42
Q

Cyclin E/CDK2 plays a critical role in which stage of cell cycle?

G1/S
G1/M
G2/M
S/G2

A

Cyclin E/CDK2 plays a critical role in which stage of cell cycle?

G1/S

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43
Q

Cyclin B/CDK1 plays a critical role in which stage of cell cycle?

G1/S
G1/M
G2/M
S/G2

A

Cyclin B/CDK1 plays a critical role in which stage of cell cycle?

G2/M

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44
Q

A 30-year-old woman with a family history positive for ovarian cancer in her mother and endometrial cancer in her grandmother. Her father recently passed away from metastatic pancreatic cancer. She is an Ashkenazi Jew. A screening mammogram is normal. Menarche occurred at 9 years and had she her first child at age 20. If a breast cancer gene mutation is present, for which of the following should she be screened or undergo surveillance?

A. Endometrial cancer
B. Cervical cancer
C. Ovarian cancer
D. Pancreatic cancer

A

A 30-year-old woman with a family history positive for ovarian cancer in her mother and endometrial cancer in her grandmother. Her father recently passed away from metastatic pancreatic cancer. She is an Ashkenazi Jew. A screening mammogram is normal. Menarche occurred at 9 years and had she her first child at age 20. If a breast cancer gene mutation is present, for which of the following should she be screened or undergo surveillance?

C. Ovarian cancer

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45
Q

A 45-year-old female presents after screening mammography to the office. A mass is seen in the lower inner quadrant of the left breast. She reports age at menarche to be 9 years, her first child-birth at age 28 years age. She never took any oral contraceptive pills but is currently on hormone replacement therapy. Her father was diagnosed with breast cancer at age 60 with positive genetic testing for breast cancer. Diagnostic mammogram and stereotactic biopsy confirm invasive ductal carcinoma. Which of the following most adversely affected the lifetime risk of this patient to develop breast cancer?
A. Early menarche
B. Hormone replacement therapy
C. Family history
D. Age at first childbirth

A

C. Family history

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46
Q
  1. What is the difference between a proto-oncogene and an oncogene? [2 marks]
A

Proto-oncogene is a gene which facilitates normal cell growth OR diffrentaion OR division OR cell migration.[1 mark]

When a proto-oncogene is mutated it becomes an oncogene, there is a gain of function which drives the initation and pregression of cancer so e.g there would be uncontrolled growth.[1 mark]

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47
Q
  1. One of the functions of the BRCA genes is to facilitate repair of DNA damage. What type of DNA repair does BRCA1 and BRCA2 facilitate? [1 mark]
A

Homologous recombination (1/2 mark) of double-stranded DNA breaks (1/2 mark).

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48
Q

What type of genes are BRCA 1/2? [1]

A

Tumour supressor gene [1]

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49
Q

If tissue has 60% differentation, what grading would does it have?

Grade I
Grade II
Grade III
Grade IV

A

If tissue has 60% differentation, what grading would does it have?

Grade I: 0-25%
Grade II: 25-50%
Grade III - 50-75%
Grade IV: 75%+

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50
Q

What is the worst TNM score someone could have?

4
5
6
7
8

A

What is the worst TNM score someone could have?

8: T4;N3;M1

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51
Q

A 66-year-old male presents after a small mass was discovered on colonoscopy. Initial workup reveals carcinoma in situ. What is the most likely TNM classification for this patient?
A. T1N1M0
B. TisN0M0
C. T0N0M0
D. TisN3M1

A

B. TisN0M0

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52
Q

A 52-year-old female presents with a newly diagnosed breast tumor. She is unsure of her exact staging but states that she remembers her tumor is T1. Under the TMN classification, a T1 tumor is most consistent with which of the following?
A. A large tumor with extensive invasion
B. Involvement of several regional lymph nodes
C. Carcinoma in situ
D. A small, minimally invasive tumor

A

D. A small, minimally invasive tumor

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53
Q

Breast cancer

E-cadherin is a phenotypic marker in breast cancer. Describe what levels of E-cadherin would be like in an individual with poor prognosis [1]

A

Low E-cadherin: worse prognosis

E-cadherin is a cell adhesion molecule that is expressed in normal breast tissue

The loss of E-cadherin expression is a very early change in lobular breast carcinogenesis and the normal protein plays a tumor-suppressive and invasion-suppressive role.

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54
Q

Melonomas larger than what size (inch /or mm) would suggest that it is malginant? [1]

A

Larger than ¼ inch
(6mm)

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55
Q

In the context of a diagnosis of prostate cancer, metastatic spinal cord compression needs to be ruled out with an

CT spine
CT brain
PET scan
MRI spine

A

MRI Spine
CT spine would be less useful as MRI is better suited at imaging neural tissues to assess for cord compression.

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56
Q

In the context of a diagnosis of prostate cancer, metastatic spinal cord compression needs to be ruled out with an

CT spine
CT brain
PET scan
MRI spine

A

MRI Spine
CT spine would be less useful as MRI is better suited at imaging neural tissues to assess for cord compression.

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57
Q

You are working as a junior doctor in a GP practice as part of one of your rotations. You are reviewing the bloods of a 74-year-old male patient who presented with nausea and intermittent vomiting. The patient also complained of ‘aching all over’ especially in his back and limbs, he says over the last few months he found himself feeling low. He suspects his low mood has led to weight loss and has lost 15kg in the past 3 months. He has been smoking 40 cigarettes a day for the past 60 years and complains of having a ‘smoker’s cough’, explaining that sometimes his handkerchief is ‘red stained’.

On review of his blood work, you notice marked hypercalcaemia, anaemia and raised white cells.

Based on these findings, what is the most likely diagnosis?

Squamous cell carinoma of the lung
COPD
Ductal carcinoma in situ
Chronic renal failure
Parathyroid adenoma

A

Squamous cell carinoma of the lung

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58
Q

Mrs Frank is a 62-year-old lady who presents to you with a two-day history of lower back pain. She tells you that started gradually and has been progressively worsening. Upon further questioning, she tells you that the pain radiates down both legs and she has been a bit wobbly on her feet. She has also been incontinent of urine this afternoon. You read in her patient notes that she has recently been diagnosed with breast cancer.

Given the most likely diagnosis, which of the following first-line management options would be most appropriate?

Prescribe bisphosphonates
Urgent MRI scan
Urgent full body x-ray
Insert a catheter and organise follow up in a week
Reassurance and NSAID analgesia

A

Urgent MRI scan

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59
Q

A sixty-year-old female presents to the acute medical unit with a two-month history of weight loss and fatigue. Abdominal examination is significant for splenomegaly and an FBC reveals anaemia and leukocytosis (WCC of 48). The patient is referred to haematology and a diagnosis of chronic myeloid leukaemia is made.

Which of the following medications has dramatically improved prognosis in recent years?

Infliximab
Imatinib
Vincristine
Rituximab

A

Imatinib

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60
Q

A patient with infective endocarditis has Streptococcus bovis grown on blood cultures.

Which of the following cancers should this result raise suspicion for?

Bladder
Oesophageal
Lung
Gastric
Colorectal

A

Colorectal

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61
Q

A mutation of which gene is most strongly associated with colon cancer?

BRCA2
RB1
p53
TSC1
BRCA1

A

A mutation of which gene is most strongly associated with colon cancer?

BRCA2
RB1
p53
TSC1
BRCA1

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62
Q

Which type of surgical intervention targeted to make a patient’s symptoms less severe?

Resection
Reconstruction
Treatment
Palliation

A

Which type of surgical intervention targeted to make a patient’s symptoms less severe?

Resection
Reconstruction
Treatment
Palliation

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63
Q

This image shows a method of biopsy. What is it?

Transcutaneous
Endoscopic Biopsy
Laparoscopic
Image-directed
Open incisional ( portion of the tumor)
Open excisional

A

This image shows a method of biopsy. What is it?

Transcutaneous
Endoscopic Biopsy
Laparoscopic
Image-directed
Open incisional ( portion of the tumor)
Open excisional

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64
Q

This image shows a method of biopsy. What is it?

Transcutaneous
Endoscopic Biopsy
Laparoscopic
Image-directed
Open incisional ( portion of the tumor)
Open excisional

A

This image shows a method of biopsy. What is it?

Transcutaneous
Endoscopic Biopsy
Laparoscopic
**Image-directed **
Open incisional ( portion of the tumor)
Open excisional

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65
Q

Which type of surgical treatment would be used for the removal of lymph nodes and an organ/s

Local resection
Radical resection
Supra-radical resections
Surgery for metastasis/recurrence
Surgical management of complications

A

Which type of surgical treatment would be used for the removal of lymph nodes and an organ/s

Local resection
Radical resection
Supra-radical resections
Surgery for metastasis/recurrence
Surgical management of complications

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66
Q

Dukes Classification is used to assess the extent of which type of cancer

Brain
Renal
Liver
Colorectal
Duodenal

A

Dukes Classification is used to assess the extent of which type of cancer

Brain
Renal
Liver
Colorectal
Duodenal

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67
Q

A 75-year-old man presents with a three-month history of dyspnea, night sweats, and recurrent hemoptysis. History is significant for a 40-pack-year history of smoking. He also reports unintentionally losing 20 lbs (9 kg) of weight in the past two months. Vital signs on presentation are normal except for an oxygen saturation of 92% on room air. CT scan of the chest with IV contrast shows a 3.5 cm endobronchial mass in the distal left main bronchus. Histopathological evaluation of CT-guided biopsy of the mass confirms a diagnosis of metastatic non-small cell lung cancer. Additionally, the tumor demonstrates high PD-L1 expression. What is the best next therapeutic step in the management of this patient?

A. Infliximab
B. Atezolizumab
C. Rituximab
D. Natalizumab

A

A 75-year-old man presents with a three-month history of dyspnea, night sweats, and recurrent hemoptysis. History is significant for a 40-pack-year history of smoking. He also reports unintentionally losing 20 lbs (9 kg) of weight in the past two months. Vital signs on presentation are normal except for an oxygen saturation of 92% on room air. CT scan of the chest with IV contrast shows a 3.5 cm endobronchial mass in the distal left main bronchus. Histopathological evaluation of CT-guided biopsy of the mass confirms a diagnosis of metastatic non-small cell lung cancer. Additionally, the tumor demonstrates high PD-L1 expression. What is the best next therapeutic step in the management of this patient?

B. Atezolizumab

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68
Q

A 71-year-old man with metastatic urothelial carcinoma presents to the clinic for follow-up. He has had progressive disease despite platinum-based therapy. The patient’s ECOG performance status score is 1. Treatment with atezolizumab is being considered. Which of the following best describes the mechanism of action of this drug?

A. A humanized monoclonal antibody that blocks vascular endothelial growth factor A
B. A humanized monoclonal antibody that blocks tumor necrosis factor-alpha
C. A humanized monoclonal antibody directed against human cell surface PD-1
D. A humanized monoclonal antibody that binds to a4 beta-1-integrin

A

A 71-year-old man with metastatic urothelial carcinoma presents to the clinic for follow-up. He has had progressive disease despite platinum-based therapy. The patient’s ECOG performance status score is 1. Treatment with atezolizumab is being considered. Which of the following best describes the mechanism of action of this drug?

C. A humanized monoclonal antibody directed against human cell surface PD-1

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69
Q

A 54-year old male presents with a 3-month history of worsening cough with recurrent hemoptysis. He has smoked 2 packs of cigarettes a day for the past 30 years. He has had a 10kg(22lb) weight loss during this period. His temperature is 37.3 C (99.1F), blood pressure is 120/76mm Hg, respirations per minute are 20, the pulse is 70/min. A chest x-ray shows a 3-cm mass in his left upper lung lobe with centrally located cavitation. Subsequently, a diagnosis of squamous non-small cell lung cancer is made. Which of the following drugs is approved for use in first-line metastatic squamous NSCLC in combination with paclitaxel and carboplatin?
A. Pembrolizumab
B. Natalizumab
C. Rituximab
D. Eculizumab

A

A 54-year old male presents with a 3-month history of worsening cough with recurrent hemoptysis. He has smoked 2 packs of cigarettes a day for the past 30 years. He has had a 10kg(22lb) weight loss during this period. His temperature is 37.3 C (99.1F), blood pressure is 120/76mm Hg, respirations per minute are 20, the pulse is 70/min. A chest x-ray shows a 3-cm mass in his left upper lung lobe with centrally located cavitation. Subsequently, a diagnosis of squamous non-small cell lung cancer is made. Which of the following drugs is approved for use in first-line metastatic squamous NSCLC in combination with paclitaxel and carboplatin?
A. Pembrolizumab

70
Q

Rituximab targets B-lymphomas by targeting which cell receptor on malignant B cells? [1]

A

CD20

71
Q

The majority of humanised monoclonal antibodies use which Ig as a backbone?

IgA
IgD
IgE
IgG
IgM

A

IgG

72
Q

Which of the following is targeted by Pembrolizumab

PD-1
CTLA-4
PD1-Ligand
LAG-3
PD2-Ligand

A

PD-1

73
Q

Which cascade is perhaps the most important oncogenic driver of human cancers?

PI3 Kinase
MAP Kinase
KRAS
AKT

A

Which cascade is perhaps the most important oncogenic driver of human cancers?

PI3 Kinase
MAP Kinase
KRAS
AKT

74
Q

Which of the following is targeted by Rituximab

CD10
CD12
CD15
CD19
CD20

A

Which of the following is targeted by Rituximab

CD10
CD12
CD15
CD19
CD20

75
Q

Which of the following is targeted by Atezolizumab

PD-1
CTLA-4
PD1-Ligand
LAG-3
PD2-Ligand

A

Which of the following is targeted by Atezolizumab

PD-1
CTLA-4
PD1-Ligand
LAG-3
PD2-Ligand

76
Q

Which of the following is an example of a CAR-T drug?

Tisagenlecleucel (Kymriah)
Atezolizumab
Rituximab
Ipililumbab
Nivolumab

A

Which of the following is an example of a CAR-T drug?

Tisagenlecleucel (Kymriah)

77
Q

Which of the following binds to CD20 in its mechansim of action?

Tisagenlecleucel (Kymriah)
Atezolizumab
Rituximab
Ipililumbab
Nivolumab

A

Which of the following binds to CD20
in its mechansim of action?

Rituximab

78
Q

Which of the following binds to CTLA4?

Tisagenlecleucel (Kymriah)
Atezolizumab
Rituximab
Ipililumbab
Nivolumab

A

Which of the following binds to CTLA4?

Tisagenlecleucel (Kymriah)
Atezolizumab
Rituximab
Ipililumbab
Nivolumab

79
Q

The patient is enrolled in a clinical trial of chimeric antigen receptor-engineered T cells (CAR-T cells). So far, in the early clinical trials, chimeric antigen receptor-engineered T cells (CAR-T cells) have targeted which receptor in the treatment of acute lymphoblastic leukemia?

A. CD5
B. CD19
C. CD45
D. CD99

A

The patient is enrolled in a clinical trial of chimeric antigen receptor-engineered T cells (CAR-T cells). So far, in the early clinical trials, chimeric antigen receptor-engineered T cells (CAR-T cells) have targeted which receptor in the treatment of acute lymphoblastic leukemia?

A. CD5
B. CD19
C. CD45
D. CD99

80
Q

The first-line FDA-approved agent to treat metastatic non-small cell lung cancer is being considered for a 67-year-old patient. It is most appropriate to evaluate this patient for which gene mutation before initiating treatment?

A. KRAS
B. p53
C. Fragile histidine triad (FHIT)
D. Epidermal growth factor receptor (EGFR)

A

The first-line FDA-approved agent to treat metastatic non-small cell lung cancer is being considered for a 67-year-old patient. It is most appropriate to evaluate this patient for which gene mutation before initiating treatment?

A. KRAS
B. p53
C. Fragile histidine triad (FHIT)
D. Epidermal growth factor receptor (EGFR)

81
Q

A 61-year-old female with a known history of non-small cell lung cancer with metastasis to bone and EGFR mutation-positive presents to the oncology clinic to discuss treatment options. The clinician mentions a drug to her as the current first-line treatment option for her form of cancer. The first-line treatment option for this patient is from which of the following drug classes?

A. PCSK9 inhibitors
B. Tyrosine kinase inhibitors
C. Anti-platelet IIb/IIIa receptors
D. TNF alpha inhibitors

A

A 61-year-old female with a known history of non-small cell lung cancer with metastasis to bone and EGFR mutation-positive presents to the oncology clinic to discuss treatment options. The clinician mentions a drug to her as the current first-line treatment option for her form of cancer. The first-line treatment option for this patient is from which of the following drug classes?

A. PCSK9 inhibitors
B. Tyrosine kinase inhibitors
C. Anti-platelet IIb/IIIa receptors
D. TNF alpha inhibitors

82
Q

Ras mutation is most associated with which type of cancer?

Non-small cell lung cancer
Colon cancer
Pancreatic cancer
Papillary thyroid cancer

A

Pancreatic cancer

83
Q

Trastuzumab (Aka Herceptin) inhibits which receptor:

HER2
HER2/HER3
EGFR
VEGF

A

Trastuzumab (Aka Herceptin) inhibits which receptor:

HER2
HER2/HER3
EGFR
VEGF

84
Q

Pertuzumab inhibits which receptor:

HER2
HER2/HER3
EGFR
VEGF

A

Pertuzumab inhibits which receptor:

HER2
HER2/HER3
EGFR
VEGF

85
Q

Cetuximab inhibits which receptor:

HER2
HER2/HER3
EGFR
VEGF

A

Cetuximab inhibits which receptor:

HER2
HER2/HER3
EGFR
VEGF

86
Q

Kadycycla is formed from the conjugate binding of Herceptin with which molecule? [1]
What is its role? [1]

A

DM1; which is an anti-microtubule agent

87
Q

A 65-year-old man presents after a recent diagnosis of poorly differentiated squamous cell carcinoma of the tongue. He has a 30 pack-year smoking history. Vital signs are within normal limits. Cervical lymphadenopathy is present on palpation, and a large mass is present on the lateral aspect of the tongue. Laboratory studies show a serum creatinine level of 2 mg/dL. CT of the head and neck shows a large mass on the right lateral border of the tongue. Multiple, enlarged, right-sided cervical lymph nodes are also noted, with the largest being 2.5 cm. CT chest is negative. Molecular testing is significant for EGFR mutation. What is the best initial therapy for this patient?

A. Pembrolizumab plus radiation
B. Bevacizumab
C. Carboplatin
D. Cetuximab plus radiation

A

A 65-year-old man presents after a recent diagnosis of poorly differentiated squamous cell carcinoma of the tongue. He has a 30 pack-year smoking history. Vital signs are within normal limits. Cervical lymphadenopathy is present on palpation, and a large mass is present on the lateral aspect of the tongue. Laboratory studies show a serum creatinine level of 2 mg/dL. CT of the head and neck shows a large mass on the right lateral border of the tongue. Multiple, enlarged, right-sided cervical lymph nodes are also noted, with the largest being 2.5 cm. CT chest is negative. Molecular testing is significant for EGFR mutation. What is the best initial therapy for this patient?

D. Cetuximab plus radiation

88
Q

Which drug is prescribed as a first line tyrosine kinase receptor in small cell lung cancer?

Trastuzumab
Pertuzumab
Osimertinib
Erlotinib
Kadcycla

A

Which drug is prescribed as a first line tyrosine kinase receptor in small cell lung cancer?

Trastuzumab
Pertuzumab
Osimertinib
Erlotinib
Kadcycla

89
Q

Which drug is prescribed if a mutation to a tyrosine kinase receptor in small cell lung cancer occurs

Trastuzumab
Pertuzumab
Osimertinib
Erlotinib
Kadcycla

A

Which drug is prescribed if a mutation to a tyrosine kinase receptor in small cell lung cancer occurs

Trastuzumab
Pertuzumab
Osimertinib
Erlotinib
Kadcycla

90
Q

Which cascade is perhaps the most important oncogenic driver of human cancers?

PI3 Kinase
MAP Kinase
KRAS
AKT

A

Which cascade is perhaps the most important oncogenic driver of human cancers?

PI3 Kinase
MAP Kinase
KRAS
AKT

91
Q

Which drug prevents the HER2/HER3 dimer from forming?

Trastuzumab
Pertuzumab
Cetuximab
Kadcycla

A

Which drug prevents the HER2/HER3 dimer from forming?

Trastuzumab
Pertuzumab
Cetuximab
Kadcycla

92
Q

Herceptin is also known as

Trastuzumab
Pertuzumab
Cetuximab
Kadcycla

A

Herceptin is also known as

Trastuzumab
Pertuzumab
Cetuximab
Kadcycla

93
Q

Which drug stops HER2 binding to another HER2

Trastuzumab
Pertuzumab
Cetuximab
Kadcycla

A

Which drug stops HER2 binding to another HER2

Trastuzumab
Pertuzumab
Cetuximab
Kadcycla

94
Q

Tarceva
(Erlotinib) targets which of the following

HER2
HER2/HER3
EGFR
VEGF

A

Tarceva
(Erlotinib) targets which of the following

HER2
HER2/HER3
EGFR
VEGF

95
Q

Which drug has a side effect of a rash?

Trastuzumab
Pertuzumab
Cetuximab
Kadcycla

A

Which drug has a side effect of a rash?

Trastuzumab
Pertuzumab
Cetuximab
Kadcycla

96
Q

Which drug causesa decline in left ventricular function AND congestive heart failure

Trastuzumab
Pertuzumab
Cetuximab
Kadcycla

A

Which drug causesa decline in left ventricular function AND congestive heart failure

Trastuzumab
Pertuzumab
Cetuximab
Kadcycla

97
Q

Which drug blocks ATP binding to tyrosine kinase receptor

Trastuzumab
Pertuzumab
Osimertinib
Erlotinib
Kadcycla

A

Which drug blocks ATP binding to tyrosine kinase receptor

Trastuzumab
Pertuzumab
Osimertinib
Erlotinib
Kadcycla

98
Q

Which of the following drug binds to B

Trastuzumab
Pertuzumab
Osimertinib
Erlotinib
Kadcycla

A

Which of the following drug binds to B

Trastuzumab
Pertuzumab
Osimertinib
Erlotinib
Kadcycla

99
Q

Which of the following drug binds to C

Trastuzumab
Pertuzumab
Osimertinib
Erlotinib
Kadcycla

A

Pertuzumab

100
Q

Which drug acts according to this image as a first line drug used for non-small cell lung cancer

Trastuzumab
Pertuzumab
Osimertinib
Erlotinib
Kadcycla

A

Which drug acts according to this image as a first line drug used for non-small cell lung cancer

Trastuzumab
Pertuzumab
Osimertinib
Erlotinib
Kadcycla

101
Q

Brachytherapy is a type of

surgial intervention
chemotherapy
targeted therapy
radiotherapy

A

radiotherapy: radioactive seed or implant to deliver targeted radiotherapy

102
Q

This image depicts what type of cancer treatment? [1]

A

Brachytherapy

103
Q

Stereotactic Radiosurgery useds which type of rays to deliver treatment

alpha rays
beta rays
delta rays
gamma rays

A

gamma rays

104
Q

A 67-year-old male patient with an acoustic neuroma presents with progressive left-sided hearing loss. Following an interprofessional team discussion, stereotactic radiosurgery is deemed appropriate. Which of the following best describes the treatment modality used to treat his condition?
A. Photons are accelerated against a metal target to generate x-rays
B. Electrons are accelerated against a metal target to generate photons
C. Intensity-modulated radiation therapy can only vary the shape of the beam to limit the dose
D. It is limited to extracranial disease

A

A 67-year-old male patient with an acoustic neuroma presents with progressive left-sided hearing loss. Following an interprofessional team discussion, stereotactic radiosurgery is deemed appropriate. Which of the following best describes the treatment modality used to treat his condition?

B. Electrons are accelerated against a metal target to generate photons

105
Q

Neo-adjuvant chemotherapy is common for which type of cancer

Breast
Prostate
Ovarian
Stomach

A

Ovarian cancer

106
Q

Cisplatin is a type of

alkylating agent
platinum agent
anti-metabolite agent
topoisomerase inhibitors

A

Cisplatin is a type of

alkylating agent
platinum agent
anti-metabolite agent
topoisomerase inhibitors

107
Q

methotrexate is a type of

alkylating agent
platinum agent
anti-metabolite agent
topoisomerase inhibitors

A

methotrexate is a type of

alkylating agent
platinum agent
anti-metabolite agent
topoisomerase inhibitors

108
Q

cyclophosamide is a type of

alkylating agent
platinum agent
anti-metabolite agent
topoisomerase inhibitors

A

cyclophosamide is a type of

alkylating agent
platinum agent
anti-metabolite agent
topoisomerase inhibitors

109
Q

which of the following form adducts in their mechanism of action

alkylating agent
platinum agent
anti-metabolite agent
topoisomerase inhibitors

A

which of the following form adducts in their mechanism of action

alkylating agent
platinum agent
anti-metabolite agent
topoisomerase inhibitors

110
Q

which of the following form hemorrhagic cystitis as a side effect?

alkylating agent
platinum agent
anti-metabolite agent
topoisomerase inhibitors

A

which of the following form hemorrhagic cystitis as a side effect?

alkylating agent
platinum agent
anti-metabolite agent
topoisomerase inhibitors

111
Q

which of the following work by forming hghly reactive molecules which bind to electron-rich nucleophilic moieties

alkylating agent
platinum agent
anti-metabolite agent
topoisomerase inhibitors

A

which of the following work by forming hghly reactive molecules which bind to electron-rich nucleophilic moieties

alkylating agent
platinum agent
anti-metabolite agent
topoisomerase inhibitors

112
Q

which of the following work by integrating into host DNA / RNA and inhibiting replication

alkylating agent
platinum agent
anti-metabolite agent
topoisomerase inhibitors

A

which of the following work by integrating into host DNA / RNA and inhibiting replication

alkylating agent
platinum agent
anti-metabolite agent
topoisomerase inhibitors

113
Q

methotrexate is a

alkylating agent
platinum agent
anti-metabolite agent
topoisomerase inhibitors

A

anti-metabolite agent

114
Q

Cyclophosphamide is a

alkylating agent
platinum agent
anti-metabolite agent
topoisomerase inhibitors

A

Cyclophosphamide is a

alkylating agent
platinum agent
anti-metabolite agent
topoisomerase inhibitors

115
Q

Which of the following is topoisomerase II inhibitor which is cardiotoxic and cause dilated cardiomyopathy

Irinotecan
Topotecan
Doxorubicin
Epirubicin

A

Doxorubicin

116
Q

tubulin active agents target which part of the cell cycle

  • G1
  • S
  • G2
  • M
A

M

117
Q

Which chemotherapy drug would cause Palmar-Planter Erythrodysesthesia?

Capecitabine
Bleomycin
Doxorubicin
Imatinib

A

Which chemotherapy drug would cause Palmar-Planter Erythrodysesthesia?

Capecitabine

118
Q

Which chemotherapy drug would cause Pulmonary Fibrosis?

Capecitabine
Bleomycin
Doxorubicin
Imatinib

A

Which chemotherapy drug would cause Pulmonary Fibrosis?

Capecitabine
Bleomycin
Doxorubicin
Imatinib

119
Q

Which chemotherapy drug would cause Palmar-Planter Erythrodysesthesia?

Capecitabine
Bleomycin
Doxorubicin
Imatinib

A

Which chemotherapy drug would cause Palmar-Planter Erythrodysesthesia?

Capecitabine
Bleomycin
Doxorubicin
Imatinib

120
Q

Which chemotherapy drug would cause Pulmonary Fibrosis?

Capecitabine
Bleomycin
Doxorubicin
Imatinib

A

Which chemotherapy drug would cause Pulmonary Fibrosis?

Capecitabine
Bleomycin
Doxorubicin
Imatinib

121
Q

Which chemotherapy drug would cause Raspberry Urine?

Capecitabine
Bleomycin
Doxorubicin
Imatinib

A

Which chemotherapy drug would cause Raspberry Urine?

Capecitabine
Bleomycin
Doxorubicin
Imatinib

122
Q

Which chemotherapy drug would cause Peri-Orbital Oedema?

Capecitabine
Bleomycin
Doxorubicin
Imatinib

A

Which chemotherapy drug would cause Peri-Orbital Oedema?

Capecitabine
Bleomycin
Doxorubicin
Imatinib

123
Q

Which chemotherapy drug would cause Flagellate Erythema ?

Capecitabine
Bleomycin
Doxorubicin
Imatinib

A

Which chemotherapy drug would cause Flagellate Erythema ?

Capecitabine
Bleomycin
Doxorubicin
Imatinib

124
Q

What is drug A called? [1]

A

Pertuzumab

125
Q

Robotic retroperitoneal lymph node dissection would be used to treat

Prostatic cancer
Bladder cancer
Testis cancer
Renal cancer

A

Robotic retroperitoneal lymph
node dissection would be used to treat

Prostatic cancer
Bladder cancer
Testis cancer
Renal cancer

126
Q

Which of the following prevents HER2 dimerisation

Trastuzumab
Pertuzumab
Osimertinib
Erlotinib
Kadcycla

A

Pertuzumab

127
Q

Brachytherapy can be used to treat cancer in which location

Breast
Lung
Cervix
Liver
Stomach

A

Prostate & cervix

128
Q

A 67-year-old woman with breast cancer is told by her oncologist that she will require chemotherapy after surgery

What is this type of treatment called?

Adjuvant
Curative
Neo-adjuvant
Palliative
Primary

A

Adjuvant

129
Q

A 67-year-old woman with ovarian cancer is told by her oncologist that she will require chemotherapy before surgery

What is this type of treatment called?

Adjuvant
Curative
Neo-adjuvant
Palliative
Primary

A

Neo-adjuvant

130
Q

There are certain histological features that are characteristic of neoplasia.

Which of the following are associated with a benign tumour?

High mitotic rate

High nuclear:cytoplasmic ratio

Irregular margins

Organised tissue

Presence of necrosis

A

Organised tissue

131
Q

Malignant and benign tumours have different clinical behaviours.

Which one of the following is a pathological sign of benign tumours?

More frequent and abnormal mitoses

Poorly cohesive and infiltrative

Regional and distant metastases

Slow progressive growth rate

Various degrees of anaplasia

A

Slow progressive growth rate

132
Q

Immunotherapy is the latest novel treatment for cancer.

Which immunotherapeutic technique has shown dramatic responses in acute lymphoblastic leukaemia (ALL)?

Cancer vaccines

CAR T-cells

PD1 checkpoint inhibitor

Pembrolizumab

Rituximab

A

CAR T-cells

133
Q

Erlotinib is an orally administered small molecule inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase used to treat

Small cell lung cancer
Non-small cell lung cancer
Adenocarcinoma
Squamous cell cancer

A

Erlotinib is an orally administered small molecule inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase used to treat

Small cell lung cancer
Non-small cell lung cancer
Adenocarcinoma
Squamous cell cancer

134
Q

Genetic alterations within cells can predispose to the formation of tumours and eventually cancers in the body.

Which of the following statements best describes an oncogene?

An altered gene that controls the cells structure and function

An altered gene that inhibits the growth of differentiated cells

An altered gene that promotes apoptosis and inhibits necrosis of cells.

An altered gene that promotes cell growth and division

An altered gene that regulates the metabolism of tumour cells

A

An altered gene that promotes cell growth and division

135
Q

Tumours are classified on the basis of their cell/tissue of origin.

What is a benign tumour arising from adipose tissue (fat) called?

Adipocyte adenoma

Adipoma

Leioangiomyoma

Leiomyoma

Lipoma

A

Lipoma

136
Q

;Diagnostic tests like biopsies and imaging are used to determine a cancer’s grade and its stage.

Which of the following is considered a staging criterion?

Cytological atypia

Mitotic activity

Necrosis

Resemblance/lack of resemblance to tissue of origin

Spread to distant organs

A

Spread to distant organs

137
Q

There are three checkpoints in the cell cycle which allow fidelity of DNA replication and cell division.

Which of the following proteins are most likely to be mutated if a damaged cell does not stop at the G2/M checkpoint?

B-cell lymphoma 2 (Bcl-2)

BRCA 1 (breast cancer 1)

Myc

p53

pRB (retinoblastoma protein)

A

BRCA 1 (breast cancer 1)

138
Q

Human blood contains chemical buffers which are able to neutralise a small amount of added acid or base.

Which of the following is the most important buffer system in the blood?

Ammonium buffer system

Carbonic acid-bicarbonate buffer system

Haemoglobin buffer system

Phosphate buffer system

Plasma proteins buffer system

A

Carbonic acid-bicarbonate buffer system

139
Q

DNA hypermethylation is observed in the 5’ untranslated region of the genome near to promoter regions of genes, resulting in transcriptional silencing.

On which DNA base is hypermethylation most likely to occur?

Adenosine

Cytosine

Guanine

Inosine

Thymine

A

Cytosine

140
Q

Abnormal epigenetic modifications can be observed in cancer cells. For example, hypomethylation is observed in the 3’ untranslated region of tumour suppressor genes.

What is the effect of this epigenetic modification?

Activate transcription factors

Enhance tumour suppressor gene expression

Increase the association between histones and the DNA

Promote gene silencing

Promote genomic instability

A

Promote genomic instability

141
Q

Cancers are initiated and progress by mutations in genes which result in either a gain or loss of function.

Which of the following best describes the gain of function mutation observed in lung adenocarcinoma?

Mutation in CDKN2A (cyclin dependent kinase inhibitor)

Mutation in Rb (retinoblastoma protein)

Mutation in EGFR (epidermal growth factor receptor)
Mutation in MYC

Mutation in TP53 (tumour protein 53)

A

Mutation in EGFR (epidermal growth factor receptor)

142
Q

DNA damage from ultra violet light results in the formation of pyrimidine dimers.

Which DNA repair mechanism can correct this mutation?

Base excision repair

Homologous double strand recombination

Mismatch repair

Non-homologous double strand end joining

Nucleotide excision repair

A

Nucleotide excision repair

143
Q

The levels of serum enzymes can be used to detect damage in specific tissues.

Elevated levels of which of the following enzymes specifically indicates prostatic carcinoma?

Acid phosphatase

Alkaline phosphatase

Aspartate transaminase

Creatinine kinase

Lactate dehydrogenase

A

Acid phosphatase

144
Q

TNM staging of a tumour provides information for diagnosis, prognosis and treatment.

If a breast tumour sample has been staged as TxN1M0 what would be the best description for this tumour?

It is 2cm across or less, there is nodal involvement and the tumour has not metastasised.

It is more than 2 centimetres but no more than 5 centimetres across, there is no nodal involvement and the tumour has not metastasised.
The tumour size can't be assessed, there is no nodal involvement and the tumour has not metastasised.
The tumour size can't be assessed, there is no nodal involvement and the tumour has metastasised.
The tumour size can't be assessed, there is nodal involvement and the tumour has not metastasised.
A

The tumour size can’t be assessed, there is nodal involvement and the tumour has not metastasised.

145
Q

Stem cells are continuously dividing cells that are required to maintain cell populations in a number of tissues.

What is the most common cause of cell senescence in stem cells?

Accumulation of point mutations

Changes in protein production

Epigenetic changes

Mitochondrial damage

Shortening of telomeres

A

Shortening of telomeres

146
Q

Caspases are proteins that initiate and execute the process of apoptosis in cells.

Which of the following caspase proteins is essential to initiate apoptosis through the extrinsic pathway?

Caspase 3
Caspase 6
Caspase 7
Caspase 8
Caspase 9

A

Caspase 8

147
Q

Which of the following prevents assembly of microtubules and at higher doses inhibit mitotic spindle formation

Vinblastine
Docetaxel
Cisplatin
Bleomycin
Cyclophoshamide

A

Vinblastine: vinca alkaloids prevent assembly of microtubules

148
Q

Label A & B [2]

A

A: Vinca alkaloids
B: Taxanes

149
Q

Which of the following inhibits disassembly of microtubules

Vinblastine
Docetaxel
Cisplatin
Bleomycin
Cyclophoshamide

A

Which of the following inhibits disassembly of microtubules

Vinblastine
Docetaxel : taxane
Cisplatin
Bleomycin
Cyclophoshamide

150
Q

Which of the following is an example of an alkylating agent chemotherapy

Vinblastine
Docetaxel
Cisplatin
Bleomycin
Cyclophoshamide

A

Which of the following is an example of an alkylating agent chemotherapy

Vinblastine
Docetaxel
Cisplatin
Bleomycin
Cyclophoshamide

151
Q

Neoadjuvent chemotherapy is common for which type of cancer

Liver
Prostate
Kidney
Ovarian

A

Ovarian

152
Q

Which of the following is formed from cytotoxic glycopeptide antibiotics isolated from the fungus streptomyces verticillus

Vinblastine
Docetaxel
Cisplatin
Bleomycin
Cyclophoshamide

A

Bleomycin

153
Q

Which of the following is an alkylating agent?

Trabectedin
L-Asparaginase
Actinomycin-D
Busulfan

A

Which of the following is an alkylating agent?

Trabectedin
L-Asparaginase
Actinomycin-D
Busulfan

154
Q

Which of the following is derived from E. coli and deprives tumour cells of the required amino acids and inhibits protein synthesis

Trabectedin
L-Asparaginase
Actinomycin-D
Busulfan

A

L-Asparaginase

155
Q

Which of the following binds to the minor groove of DNA, bending the helix towards the major groove, which leads to interference with the intracellular transcription pathways and DNA-repair pathways

Trabectedin
L-Asparaginase
Actinomycin-D
Busulfan

A

Which of the following binds to the minor groove of DNA, bending the helix towards the major groove, which leads to interference with the intracellular transcription pathways and DNA-repair pathways

Trabectedin
L-Asparaginase
Actinomycin-D
Busulfan

156
Q

Which of the following exerts cytotoxic effects by intercalation between guanine-cytosine base pairs with inhibition of the synthesis of messenger RNA

Trabectedin
L-Asparaginase
Actinomycin-D
Busulfan

A

Which of the following exerts cytotoxic effects by intercalation between guanine-cytosine base pairs with inhibition of the synthesis of messenger RNA

Trabectedin
L-Asparaginase
Actinomycin-D
Busulfan

157
Q

hemorrhagic cystitis is an AE of which of the following?

Vinblastine
Docetaxel
Cisplatin
Bleomycin
Cyclophoshamide

A

Cyclophoshamide: alkylating agents

158
Q

Methotrexate inhibits which of the following

G1
S
G2
M

A

S

159
Q

Bleomycin inhibits which of the following

G1
S
G2
M

A

Bleomycin inhibits which of the following

G2

160
Q

paclitaxel & docetaxel inhibit which cell cycle stage

G1
S
G2
M

A

M

161
Q

Trastuzumab - emtansine (Kadcycla) is used at which stage of breast cancer treatment?

First line
Second line
Third line
Fourth line

A

Second line

162
Q

A combination of pertuzumab, trastuzumab and docetaxel is used at which stage of breast cancer treatment?

First line
Second line
Third line
Fourth line

A

First line

163
Q

Which of the following is topoisomerase II inhibitor

A
164
Q

Which drug has a mechanism that works by the development of covalent adducts

Vinblastine
Docetaxel
Cisplatin
Bleomycin
Cyclophoshamide

A

Cisplatin

165
Q

What drug class is Doxorubicin? [1]

A

Topoisomerase-II inhibitor

166
Q

What drug class are:
* Irinotecan
* Topotecan

A

Topoisomerase-I inhbitors

167
Q

Paclitaxel is a

Vinca alkaloid
Taxane
Topoisomerase I inhibitor
Topoisomerase II inhibitor

A

Taxane: prevents tublin disassembly

168
Q

Name a cancer that neo-adjuvant chemotherapy is common for [1]

A

Ovarian

169
Q

Which drug is included alongside trastuzumab & pertuzumab in first line breast cancer treamtnet? Also state its drug class [2]

A

docetaxel: taxane

170
Q

hemorrhagic cystitis is associated with

Vinblastine
Docetaxel
Cisplatin
Bleomycin
Cyclophoshamide

A

Cyclophoshamide

171
Q

Most common form of radiotherapy are the [], which are used to treat deeper cancers.

A

Most common form of radiotherapy are the MV photons, which are used to treat deeper cancers.

Cancer (11 decks)

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