Cancer Genes

Question 1

Chromosome 3

Answer 1

Gene: VHL (Von Hippel Lindau)
Tumor: Renal cell carcinoma

Question 2

Chromosome 5

Answer 2

Gene: APC
Tumor: Colon cancer (familial adenomatous polyposis)

Question 3

Chromosome 11

Answer 3

Gene: WT-1 and WT-2
Tumor: Wilms tumor (kidney cancer in children)

Question 4

Chromosome 13

Answer 4

Gene: Rb
Tumor: Retinoblastoma and osteosarcoma

Gene: BRCA-2
Tumor: Breast cancer

Question 5

Chromosome 17

Answer 5

Gene: p53
Tumor: Lung, breast, colon, etc. (Li–Fraumeni syndrome)

Gene: BRCA-1
Tumor: Breast/ovarian

Gene: NF1
Tumor: Neurofibroma

Question 6

Chromosome 18

Answer 6

Gene: DCC (“Deleted in Colon Cancer”)
Cancer: Colon

Question 7

Chromosome 22

Answer 7

Gene: NF2
Cancer: Acoustic neuroma and meningiomas

Question 8

Chromosome 9

Answer 8

Gene: ?
Cancer: Familial Melanoma

Question 9

Translocation 8-14

Answer 9

Burkitt’s lymphoma

Question 10

Translocation 11-14

Answer 10

Mantle cell lymphoma

Question 11

Translocation 18-14

Answer 11

Follicular lymphoma

Question 12

What gene is expressed on chromosome 14 in B cells?

Answer 12

Antibody heavy chain genes on chromosome 14

translocation close to enhancer of these antibody genes

Question 13

Translocation 9-22

Answer 13

“Philadelphia” chromosome: BCR-ABL (tyrosine kinase, oncogene)

Chronic myelogenous leukemia (CML)

Treatment with Imatinib