Cancer Gene’s and their associations Flashcards
1
Q
BRCA1 (Chromosome 17) - associated pathology
A
Breast Cancer = 70% lifetime risk
Ovarian Cancer = 40% lifetime risk
2
Q
BRCA2 (Chromosome 13) - associated pathology
A
Breast cancer = 70% lifetime risk
Ovarian cancer = 20% lifetime risk
3
Q
Pten - associated pathology
A
Cowden
4
Q
TP 53 - associated pathology
A
Li-Fraumeni syndrome
5
Q
MLH-1/MSH-2/MSH-6/PMS-2
A
Lynch Syndrome
6
Q
CDKN - associated pathology
A
Melanoma
7
Q
Her2 Neu/Neu
A
Breast CA
8
Q
CA 19-9 - associated pathology
A
Pancreatic cancer and GI cancer
9
Q
HE 4 - associated pathology
A
Human epididmus - marker for epithelial cancers of the ovary
10
Q
APC - associated pathology
A
Familial adenomatous polyps
11
Q
STK 11 - associated pathology
A
Peutz-Jeghers
