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Pulmonary Week 3 > Cancer Drugs MOAs and AEs > Flashcards

Cancer Drugs MOAs and AEs Flashcards

1
Q

Carboplatin/Cisplatin

A

Forms DNA intrastrand crosslinks and adducts

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2
Q

Cyclophosphamide/Ifosfamide

A

Pro-drug of active alkylating moiety

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3
Q

Docetaxel/Paclitaxel

A

Microtubule stabilizer inhibiting depolymerization

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4
Q

Doxorubicin

A

Intercalator, free radical generator, too II inhibitor

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5
Q

Etoposide, VP-16

A

DNA-topo II complex stabilizer

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6
Q

Gemcitabine

A

DNA polymerase inhibitor via incorporation of triphosphate form during DNA synthesis

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7
Q

Irinotecan/Topotecan

A

DNA-topo I complex stabilizer

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8
Q

Pemetrexad

A

DHFR Inhibitor

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9
Q

Vincristine/Vinorelbine

A

Microtubule inhibitor; tubules disintegrate into spiral aggregates/ protofilaments

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10
Q

Which is more toxic, Cisplatin or Carboplatin?

A

Cisplatin

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11
Q

Toxicities of Carboplatin/Cisplatin?

A
  • **Nephro and ototoxicity (dose-limiting toxicity)

- peripheral neuropathy (more in cisplatin- numbness in distal extremities)

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12
Q

What drug is often given with Carboplatin/Cisplatin to prevent nephrotoxicity?

A

Amifostine

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13
Q

AEs of Cyclophosphamide /Ifosfamide

A

Hemorrhagic cystitis from acrolein

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14
Q

AEs of Docetaxel/Paclitaxel

A
  • hypersensitivity
  • diarrhea
  • mucositis
  • peripheral neuropathy
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15
Q

AEs of Doxorubicin?

A
  • red-orange urine
  • chronic cardiomyopathy and CHF from free radicals
  • cardiac arryhthmias
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16
Q

How are the CV AEs of Doxorubicin avoided?

A

Dexrazoxane

17
Q

AEs of Etoposide, VP-16

A
  • hypotension
  • hypersensitivity
  • N/V
18
Q

AEs of Gemcitabine?

A
  • interstitial pneumonitis
  • mucositis
  • diarrhea
19
Q

AEs of Irinotecan/Topotecan?

A
  • asthenia

- N/V

20
Q

AEs of Pemetrexed?

A
  • hepatic fibrosis
  • pneumonitis
  • mucositis
  • diarrhea
21
Q

What drug is given to prevent the toxicities of Pemetrexed?

A

Leucovorin

22
Q

AEs of Vinblastine/Vinorelbine?

A
  • SIADH with vincristine
  • constipation
  • peripheral neuropathy
23
Q

Two other drugs associated with peripheral neuropathy?

A

bortezomib and thalidomide

Pulmonary Week 3 (18 decks)

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