Cancer Drugs Flashcards
1
Q
Vinblastine: MOA, SE
A
MOA:
- inhibits MT formation of mitotic spindle SE:
- alopecia
- constipation
- myelosuppression
- neurotoxicity (rare)
2
Q
Cancer drugs that act in the M phase of the cell cycle
A
vinca alkaloids=inhibit MT fxn/spindle formation
- vincristine
- vinblastine paclitaxel
- binds to tubulin and hyperstabilizes MTs that have already polymerized ==> prevents spindle breakdown
3
Q
5-fluorouracil: MOA, use
A
- anti-metabolite
- prevents formation of thymidine vua inhibition of thymidylate synthase uses
- slow-growing solid tumors:
- breast
- ovarian
- pancreatic
- colorectal
- gastric carcinomas
4
Q
6-mercaptopurine: MOA, use
A
- anti-metabolite
- inhibits formation of purines
- use = cancer drug
5
Q
Methotrexate: MOA, use
A
- anti-metabolite
- inhibts dihydrofolate reductase ==> inhibition of DNA synthesis (via same pathway as 5-fluorouracil)
- use = cancer drug
6
Q
Busulfan: MOA, use
A
- DNA alkylating agent (cell cyle nonspecific)
* use = CML
7
Q
Bleomycin: MOA, use, SE
A
- inhibit replication by inducing DNA strand breaks via free radical formation
- strand breakage interrupts G2 phase of cell cycle (after DNA synthesis)
- uses: testicular tumors, lymphomas, squamous cell carcinoma SE
- rales, cough
- infiltration ==> fibrosis
8
Q
Cyclophosphamide: MOA, uses, SE
A
DNA alkylating agent (cell cycle nonspecific)
- activated by CYP450
- ==> apoptosis via DNA crosslinking uses
- leukemias, lymphomas
- testicular and gyn cancers SE
- hemorrhagic cystitis
9
Q
How to prevent major side effect of cycloposphamide
A
prevent hemorrhagic cystitis via:
- adequate hdration
- IV injection of mesna
