Cancer drugs Flashcards
What is the main thing to watch out for with Cyclophosphamide (alkalating agent) ?
Bladder toxicity
Patient should drink 2 L of fluid a day
What is the main thing to watch for with Cisplatin (alkalating agent) ?
Must verify patient’s line (patent)
Watch for extravasation
antidote (sodium thiosulfate)
Methotrexate (antimetabolites)
Teratogenic
Prevents folic acid from producing
Also used in lupus and RA
Hydroxyurea (antimetabolites)
do not crush or break
also used in sickle cell
Antitumor antibiotics
interfere with DNA replication
can be cardiotoxic
Fluorouracil (antimetabolites)
do not apply with metal
topical
Tamoxifen (antineoplastic hormone inhibitor)
treats/reduces risk of breast cancer
double glove if splitting pill
need baseline bone mineral density test
Anastrozole (antineoplastic hormone inhibitor)
breast cancer
no need to double glove
need baseline bone mineral density test
epoetin alfa (cytoprotectant)
used for anemia
stimulates RBC production
Filgrastim (cytoprotectant)
helps with WBC production
leucovorin (cytoprotectant)
used with methotrexate
folic acid
HUman interleukin 11 (cytoprotectant)
helps with thrombocytopenia
get PLTs up
prevent bleeding
Colony stimulating factor (cytoprotectant)
WBC production
What is tumor lysis syndrome
cell contents are dumped into blood stream
What is the treatment of tumor lysis syndrome?
aggressive hydration, sodium bicarb, allopurinol