antibiotics part 2 Flashcards
what is the black box warning for z-pack (erythromycin- macrolides)
liver disease, hepatotoxicity
what are the side effects of macrolides
reversible hearing loss
confusion
pseudomembranous colitis
prolong QT interval
what are some drug inetractions for z-pack
digoxin and warfarin
can cause toxicity
antacids reduce absorption
what meds if mixed with z-pack can cause cardiac arrest
fluconazole and diltiazem
what can clindamycin cause
fatal pseudomembranous colitis
what do you have to watch out for while giving vancomycin
nephrotoxic
narrow TI
trough before the 4th dose
IV is vesicant / irritant
RED MAN SYNDROME if given too fast
What are some considerations for linezolid (lipoglycopeptides)
can cause bone marrow suppression if used for too long
BBW: taken with antidepressants can cause serotonin syndrome
What are some symptoms of serotonin syndrome
muscle twitching, sweating, shivering, diarrhea
chloramphenicol
hospitalization recommended - can cause anemias
careful when given with statins
sulfonamides
hypersensitivity
skin photosensitivity
*steven johnson syndrome
how should you administer tetracycline
on an empty stomach and lots of water
remain sitting up right for 30 mins
if not you can get esophagitis
what are some considerations for tetracycline
outdated meds can cause renal failure
interactions with iron dairy and antacids
enhance digoxin effects
anticoagulant interaction
permanent discoloration of teeth
harm bone growth
bad sunburn
what is often used with daptomycin
gentamicin
dont use with statins
musckulokeletal complications
izoniazid
used in TB
BBW : liver toxicity
Rifampin
used in TB
sweat, skin and urine turn yellow/orange
