antibiotics part 3

Question 1

side effects of famcyclovir , acyclovir, valacyclovir

Answer 1

herpes drugs
can cause trombocytopenia
purpura (rash)
seizure meds less effective

Question 2

Oseltamivir

Answer 2

for the flu
give within 48 hours

Question 3

Ribavirin

Answer 3

for RSV
inhaled
very teratogenic

Question 4

Ganciclovir

Answer 4

cytomegalovirus treatment
BBW: teratogenic and bone marrow suppression

Question 5

Nucleotide Analogs (Hep B and C)

Answer 5

BBW: hepatomegaly , lactic acidosis

Question 6

Azoles (fungal)

Answer 6

liver toxicity due to hepatic necrosis

Question 7

Amphotericin B (polyene- fungal)

Answer 7

Highly toxic
BBW: multiple organ failure, resp and cardiac arrest
interaction with aminoglycosides (more nephrotoxicity)
infuse with desxtrose
assess for phlebitis

Question 8

caspofungin, micafungin (echinocandins)

Answer 8

highly bound to plasma albumin
play with patient for 15 mins (blood test)

Question 9

terbinafine

Answer 9

BBW: hepatotoxicity

Question 10

nystatin (polyene)

Answer 10

oral swish

Question 11

Mebendazole

Answer 11

hepatitis
avoid alc

Question 12

Chloroquine phosphate (antimalarials)

Answer 12

given before and after travel
retinal toxic and EKG changes
Watch liver function
BBW: carcinogenic

Question 13

LIndane

Answer 13

CNS toxicity –> seizures –> death