Cancer Chemotherapy-Targeted Therapy

Question 1

Targeted therapy pros and cons

Answer 1

Pro: ⬇️ AE vs cytotoxic agents

Con: resistance is common, don’t work for everone, testing is required

Question 2

Anti androgen therapies 
Anti estrogen therapies 
Kinase inhibitors 
Targeted delivery of toxins 
Anti angiogenesis agent 
Immunostimulants

Answer 2

Targeted therapy options

Question 3

Anti androgen therapy

Block androgens-GF

Answer 3

Rx for prostate cancer
Limited duration
AE: hot flashes, impotence, ⬇️ libido, ⬇️ muscle and bone mass

Question 4

Targeted therapy

Answer 4

MOA: target a specific growth factor to target only the affected tissue/GF

• block GF or surface receptor
• inhibit cellular enzyme
• mark cells for immune attack
• deliver toxic compounds
• inhibit angiogenesis

Question 5

Anti androgen therapy

Available products

Answer 5

1) gonadotropin releasing hormone agonists
2) GnRH antagonists
3) androgen receptor blockers
4) CYP17 inhibitors

Question 6

Leuprolide
Tiptorelin
Goserelin

Answer 6

GnRH agonists

Question 7

Aborelix

Degorelix

Answer 7

GnRH antagonists

Question 8

Flutamide
Bicalutamide
Nilitamide

Answer 8

Androgen receptor blockers

Question 9

Anti estrogen therapy options
Block estrogen (GF)
Rx for breast cancer

Answer 9

1) selective estrogen receptor modulators (SERMs)
2) pure estrogen ER antagonist
3) aromatase inhibitors

Question 10

Selective estrogen receptor modulators (SERMs)

Answer 10

Inhibit/inactive ER in specific tissues

AE: hot flashes, thromboembolism, endometrial cancer risk

Question 11

Tamoxifen
Taremifene
Raloxifene

Answer 11

SERMs

Question 12

Pure estrogen ER antagonist

-fulvestrant

Answer 12

No risk of endometrial cancer

Question 13

Aromatase inhibitors

Answer 13

Pain- musculoskeletal/joint pain

Osteoporosis

Question 14

Anastrozole
Letruzole
Exemestone

Answer 14

Aromatase inhibitors

Question 15

Kinase inhibitors

-“nib”

Answer 15

The most rapidly growing class of anti cancer drugs
-kinase: enzyme that activates/regulates proteins by -P them
AE: N/V/D, non allergic rash, myelosupression, HTN, QT prolongation, skin/hair changes, lung disease
*gastric Ph/ food sensitivity
*PO

Question 16

Multiple different types of kinase inhibitors

Answer 16

EGFR kinase inhibitors 
Bc-abl kinase inhibitors 
Multi tyrosine kinase inhibitors 
Alk inhibitors 
Braf v600e kinase inhibitors 
Antibodies 
Small molecules 
mTOR inhibitors

Question 17

Gefitnib
Cetuximab

Nilotinib
Lapatinib
Imatinib
Dasatinib
Sunitinib

Vermurfinib

Answer 17

EGFR kinase inhibitors

Multi tyrosine kinase inhibitors

Braf v600e kinase inhibitors

Question 18

Cetuximab

Panitumumab

Answer 18

Antibody kinase inhibitors

Question 19

Erlotinib
Sutinib
Vemurfinib

Answer 19

Small molecule kinase inhibitors

Question 20

Everolimus

Temsirolimus

Answer 20

mTOR inhibitor- kinase inhibitor

Question 21

Brentuximab
Ibritumimumab + yttrium
Gemtuzumab ozogamien
Kitaximab
Tositomumab + 131I tositomumab

Answer 21

Targeted delivery of toxins: monoclonal antibodies directed at a specific cell combined with a toxin

Question 22

Bevacizumab (avastin)

Answer 22

Anti angiogenesis agent: blocks the formation of new blood vessels
AE: GI perforation, bleeding, thromboembolism, altered wound healing, HTN

Question 23

Interferon Alfa 2a, interferon Alfa 2b: flu like syndrome

Aldesleukin (IL2): fever, chills, N/V, capillary leak syndrome

BCG (anti TB vaccine): ayuria, urinary frequency/hesitancy, hematouria: urinary cancer risk*- Rx to bladder-immune response- kills cells cancer and Healthy cells

Sipuleucel-T

Answer 23

Immunostimulants: revs up the body’s immune system