Cancer as an Infectious Disease - Test 1 Flashcards
What was the conclusion from cancer research in the 1970s?
- Virus-induced cancers represent only a minority of the cancer types affecting humans
What was cancer considered as?
- A candidate for infectious disease
In 1911 what virus caused cancer in chickens?
- Rous Sarcoma Virus (RSV)
- A virus can transform a normal cell into a tumor
- Rous’s protocol for inducing sarcomas in chickens
What were the two categories of disease in the 19th century?
- Bacteria - trapped in pores upon filtration
- Viruses - pass through filters
Density Dependant Inhibition (contact inhibition)
The behavior exhibited by cells propagated in monolayer culture reflects the halt in cell proliferation.
Anchorage dependence
Requirement of cells for tethering to a solid substrate before they will grow.
Cancer cells do not exhibit…
- Anchorage Dependence
- Density Dependence
Transformation
- Process of converting a normal mammalian cell into a cell having some or many attributes of a cancer cell
Transfection
- a procedure for introducing DNA or RNA molecules into cells which may thereafter be expresses transiently in such cells, in case of DNA, stably in such cells
Transduction
- [as in signal transduction]
- Process by which a gene is introduced into a cell, usually by a vector such as a viral vector.
Immortalization
- Process whereby a cell population normally having limited reproductive potential acquires the ability to multiply indefinitely
Tumorigenicity
The ability of cells to serve as founders of new tumors is often gauged experimentally by transplanting cells into appropriate hosts.
Tumorigenic
- Referring to the ability of cells to form tumors when introduced into appropriate animal hosts
Tumorigenesis
The process of forming a tumor,often involving a succession of steps.
What becomes integrated into the chromosomes of infected cells?
Retroviral genomes
