Cancer 7

Question 1

What is cell behaviour?

What external influences are detected by cells?

What external factors can influence cell division?

Answer 1

p1

Question 2

Basic behaviour of cells in culture

Question 3

Significance of cell-ECM adhesions in cell proliferation

Question 4

How mechanical continuity between cell interior and the ECM is ensured

Question 5

Integrins:Describe their general structure, what to bind to (in ECM,cytoplasm and on other cells{give specific examples}) How they take part in adhesion, and describe functions they perform in other than adhesion.

Answer 5

p 3

Question 6

Explain the different types of signalling that can occur through the integrin complex- between ECM and the cell, explain how it is achieved. Explain the significance of this signalling(between the ECM and the cell)

Answer 6

pg 5

Question 7

Explain what would happen for a control variable of growth factor and an increase in cell density

Question 8

Explain how two types of signalling control proliferation

Question 9

Co_ntact interactions between cells, Cell-cell contact between non-epithelial cells, Long-term cell-cell contacts_

Answer 9

pg 9

Question 10

Cell junctions revision

Answer 10

pg 9

Question 11

WHat happens in Contact-induced spreading of epithelial cells

Answer 11

pg 10

Question 12

Evidence Cell-cell adhesion affect proliferation

Answer 12

pg 10

Question 13

What is Function of adherens junctions and Describe Molecular organisation of adherens junctions. WHat is Adenamatous polyposis colitis and what happens in it

Answer 13

pg 13

Question 14

Describe mechanisms for contact inhibition of proliferation

Answer 14

pg 13

Question 15

Explain the impact of loss of social skills on cells

Answer 15

pg 14

Question 16

Q: Other than promoting the formation of solid tumours, what is an important consequence of loss of contact inhibition of locomotion for the progression of cancer?

Answer 16

pg 14

Question 17

c- raf and c-jun are mutated to v-raf and v-jun , we get delation of regulatory doman(T/F)

Question 18

There is growth factor dependence in tumours T/F

Answer 18

F

Question 19

How does a primary carcinoma cell metastasise?