Cancer 5

Question 1

What happens in the usual adult cell state, and what is the most obvious observation during cell cycle entry

Answer 1

pg 1

Question 2

List Key Components of Signalling Pathways in growth and cell division

Answer 2

pg 2

Question 3

Give the details of Signalling Pathways following mitogenic growth factor stimulation

Answer 3

pg 2

Question 4

Give the details of the function of receptor protein tyrosine kinase, including details of another important type of protein in your answer

Answer 4

pg 2

Question 5

Explain how Ras is activated, via growth factor stimulation

Answer 5

pg 4

Question 6

How Ras can be oncologically activated

Question 7

Give details of what RAS activates

Answer 7

pg 6

Question 8

Explain what cell cycle control is based on

Question 9

different cyclins AND different Cdks required at different stages of the cell cycle: give the details of the effects cyclins have other than cdk activation

Answer 9

pg 12

Question 10

What do Cdks do?

Answer 10

pg 14

Question 11

Explain the regulation of gene expression by retinoblastoma

Answer 11

pg 14

Question 12

Give the details of the actions of Cdk Inhibitors

Answer 12

p 16

Question 13

Recall Cell Cycle Regulatory Proteins , the Cancers they cause and the drug targets for them