Cancer 6

Question 1

What can damage DNA? And Why do we care?

Answer 1

pg 1

Question 2

Describe different methods for DNA Damage by Carcinogens

Answer 2

pg 2

Question 3

Summarise mammalian metabolism of exogenous compounds

Question 4

WHat are Polycyclic Aromatic Hydrocarbons(list?)-3

Question 5

Describe the oxidation of benzo[a]pyrene, and the effect of this

Question 6

Describe the mechanism of aflatoxin b1 and naphthylamine and explain their effects

Question 7

Give the details of the Effects of solar(UV) radiation and ionised radiation

Answer 7

pg 5

Question 8

Describe the role of p53 in dealing with cellular stress

Answer 8

pg 6

Question 9

Give the details of the different types of DNA Repair

Answer 9

pg 6

Question 10

Discuss Estimated rates of endogenous damage and repair

Question 11

Describe the fate of carcinogen-dna damage

Answer 11

pg 9

Question 12

Give the details of the tiered approach for Testing a chemical for DNA Damage

Question 13

Give the details of the Bacterial (Ames) Test for Mutagenicity of Chemicals

Answer 13

pg 10