Calcium Flashcards
Calcium- Functions
major cation in bone and teeth blood clotting transmission of nerve impulse myocardial contractions muscle contractions
how the body regulates calcium
source of calcium= diet
how the body regulates calcium- calcium absorption requires
active form of vitamin D (diet or sunlight)
how the body regulates calcium- PTH
maintain normal serum Ca level by regulating the movement of Ca into/out of bone
Ca readily available supply b/c bone
production and release are stimulated by low serum Ca level
inc bone resorption (movement of Ca out of bone)
inc GI absorption of Ca
inc renal tubule reabsorption of Ca
vit B12 absorption and use
Ca and P have inverse relationship
how the body regulates calcium- to inc Ca: PTH secretion
bone
intestine
kidneys
how the body regulates calcium- to dec Ca: Calcitonin
bone intestine kidneys produced by thyroid gland stimulated by high serum Ca level Opposes action of PTH and lowers the Ca level by dec GI absorption, inc Ca deposition into bone, promoting renal excretion
how the body regulates calcium- Vitamin D facilitates Ca absorption
Dietary intake
sunlight
Calcium info
1% in serum
ionized ca- free ca (most active form)
bound to protein (albumin)
complexed bound to other anions
Calcium info: NM activity
inc calcium stabilizes excitable membranes (Ca calms)
Calcium info: blood clotting
ca clot (CC) inc ca causes excessive clotting dec calcium (DC)- low Ca doesnt clot(bleeding)
Calcium info: teeth and bone formation
98% of it found in bone
osteoporosis-> fx
Calcium info: changes in serum pH
alter the level of ionized Ca without altering the total Ca level
a dec plasma pH (acidosis) de Ca binding to albumin (more ionized Ca)
inc plasma pH (alkalosis) inc Ca binding leading to dec ionized Ca
alteration in serum albumin levels affect total Ca level
Low albumin levels = drop in total Ca level (BUT the level of ionized Ca is not affected)
Calcium: Pt at risk- Labs
8.6-10.62 mg/dL
Hypercalcemia: Pt at risk-
high serum ca
excitability of muscles and nerves- need stronger stimulus
2/3 caused by hyperthyroidism
1/3 caused by malignancy from myeloma and breast, lung, and kidney cancer (through bone destruction from tumor invasion, or tumor secretion of a parathyroid related protein), which stimulates Ca release from bone
Hypercalcemia: Pt at risk- prolonged immobilization
bone mineral loss and inc plasma Ca concentration
Hypercalcemia: Pt at risk- rare case
vit D overdose/ inc Ca intake
Hypercalcemia: Pt at risk- etc
excess Ca- excitability of both muscles and nerves hyperparathyroidism malignancy prolonged immobility RF multiple bon Fx thiazide diuretics- inc action of PTH overuse of Ca containing meds Steroids- mobilize Ca from bone Vit D/Ca overdose
Hypercalcemia: Assessment- dec NM excitability
muscle weakness
incoordination
fatigue
Hypercalcemia: Assessment: dec peristalsis
dec peristalsis
Hypercalcemia: Assessment: Neuro
lethargy, confusion
depressed reflexes