Caffeine Flashcards
Caffeine is part of what family?
Xanthine family
Caffeine is in what products?
Coffee, tea, chocolate, etc.
Caffeine absorption?
rapid, peak around 1/2 to 2 hours
Caffeine distribution?
Rapid, can go to all tissues, brain, fetus
Caffeine metabolism?
Fast in the liver
Caffeine half life?
4-5 hours, half life is less in smokers
Caffeine excretion?
in the kidneys
Caffeine half life in babies?
Very long half life in babies, can be transferred through breast milk
Caffeine has a similar structure to which neurotransmitter?
Adenosine
Caffeine acts on which receptors?
Caffeine is a competitive antagonist for adenosine receptors
What does adenosine/caffeine (do similar things) inhibit?
Adenosine is a neurotransmitter that inhibits the release of Noradrenaline, dopamine, acetylcholine, glutamate, GABA
What type of receptors are adenosine receptors?
GPCRs
Adenosine lowers activity in cholinergic stimulatory network
How does caffeine inhibit sleep?
Caffeine blocks adenosine receptors in the basal forebrain which decreases the signals to induce sleep
What other effects does caffeine have on the body?
The receptors else where in the brain, heart (heart rate goes up), cerebral vessels, effects gastric acid secretion, causes diuresis (make you pee more)
Is there tolerance to caffeine?
Yes, Tolerance: rapid, due to an increase in receptors, mild withdrawal
