Ca Colon Flashcards

1
Q

Epidemio

CC

A

Más frecuente
3ra causa de muerte
Incidencia 3ra -9na década

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2
Q

Tipo

CC

A

In situ
Local
Regional +
Distante

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3
Q

Fr

CC

A

Genética
EII
Alcohol tabaco
Poca ingesta de fibra
Poliposis >2 cm

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4
Q

Mutación

CC

A

Gen MYH

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5
Q

Patogenia

CC

A

Adenocarcinoma
Ca. De células escamosas
Adenoescamoso

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6
Q

Clínica

CC

A

Local:
Dolor abd
Hematoquesia
Estreñimiento
Menor calibre de heces

Baja de peso, anemia y adinamia

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7
Q

Dx

CC

A

Tacto
Sangre oculta
Colonoscopia
Biopsia
Antígenos carcinoembrionario

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8
Q

Tx

CC

A

Resección amplia en bloque del tumor y ganglio
-Colectomia o proctocolectomia abdominal total
-Paliativos

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9
Q

Etapa

CC

A
  1. Limitado a la pared : Tx resección Qx
  2. Extensión a serosa, respeta ganglios: resección amplia y paliativo
  3. Afecta ganglios: paliativo
  4. Metástasis a órganos: resección de tunos y metástasis + paliativos
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10
Q

Ganglio

CC

A

N. Intermedios
N. Paracólicos
N. Principales
N. Epicolicos

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11
Q

Genes

A

Supresores: p53, DCC y APC

Protooncogenes: ras, factor de transcripción B

De proteínas reparadoras: MLH1 y MSH2

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